The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae

Journal of Bacteriology

Volumn 179, Issue 13, 1997, Pages 4123-4128

  Lucas, Claressa E ^a,b   Balthazar, Jacqueline T ^a   Hagman, Kayla E ^c   Shafer, William M ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MALTOSE BINDING PROTEIN; REGULATOR PROTEIN; REPRESSOR PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; BINDING SITE; DNA BINDING; DNA SEQUENCE; GENE EXPRESSION REGULATION; MEMBRANE TRANSPORT; NEISSERIA GONORRHOEAE; PRIORITY JOURNAL; REPRESSOR GENE;

BACTERIA (MICROORGANISMS); NEISSERIA GONORRHOEAE;

EID: 0030798952     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.13.4123-4128.1997     Document Type: Article

References (25)

1. Bertrand, K. P., K. Postle, L. V. J. Wray, and W. S. Reznikoff. 1983. Overlapping divergent promoters control expression of Tn10 tetracycline resistance. Gene 23:149-156.
2. Brennan, R. G., and B. W. I. Matthews. 1989. Structural basis of DNA-protein recognition. Trends Biochem. Sci. 14:286-290.
3. Guymon, L. F., and P. F. Sparling. 1975. Altered crystal violet permeability and lytic behavior in antibiotic-resistant and -sensitive strains of Neisseria gonorrhoeae. J. Bacteriol. 124:757-763.
4. Guymon, L. F., D. L. Walstad, and P. F. Sparling. 1978. Cell envelope alterations in antibiotic-sensitive and -resistant strains of Neisseria gonorrhoeae. J. Bacteriol. 136:391-401.
5. Hagman, K. E., W. Pan, B. G. Spratt, J. T. Balthazar, R. C. Judd, and W. M. Shafer. 1995. Resistance of Neisseria gonorrhoeae to hydrophobic antimicrobial agents is modulated by the mtrRCDE efflux system. Microbiology 141: 611-622.
6. Hagman, K. E., and W. M. Shafer. 1995. Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae. J. Bacteriol. 177:4162-4165.
7. Hillin, W., and C. Berens. 1994. Mechanisms underlying expression of Tn10 encoded tetracycline resistance. Annu. Rev. Microbiol. 48:345-369.
8. Levy, S. B. 1992. Active efflux mechanisms for antimicrobial resistance. Antimicrob. Agents Chemother. 36:695-703.
9. Lu, F., and G. Churchward. 1994. Conjugative transposition: Tn916 integrase contains two independent DNA binding domains that recognise different DNA sequences. EMBO J. 13:1541-1548.
10. Lucas, C. E., K. E. Hagman, D. C. Stein, and W. M. Shafer. 1995. Importance of lipooligosaccharide structure in determining gonococcal resistance to hydrophobic antimicrobial agents resulting from the mtr efflux system. Mol. Microbiol. 16:1001-1009.
11. Ma, D., M. Alberti, C. Lynch, H. Nikaido, and J. E. Hearst. 1996. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. Mol. Microbiol. 19:101-112.
12. Ma, D., D. N. Cook, M. Alberti, N. G. Pon, H. Nikaido, and J. E. Hearst. 1995. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol. Microbiol. 16:45-55.
13. Maness, M. J., and P. F. Sparling. 1973. Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhneae. 3. Infect. Dis. 128:321-330.
14. McAllister, C. F., and D. S. Stephens. 1973. Analysis in Neisseria meningitidis and other Neisseria species of genes homologous to the FKBP immunophilin family. Mol. Microbiol. 10:13-24.
15. McIver, K. S., A. S. Heath, B. D. Green, and J. R. Scott. 1995. Specific binding of the activator Mga to promoter sequences of the emm and scpA genes in the group A streptococcus. J. Bacteriol. 177:6619-6624.
16. Morse, S. A., P. G. Lysko, L. McFarland, J. S. Knapp, E. Sandstrom, C. Critchlow, and K. K. Holmes. 1982. Gonococcal strains from homosexual men have outer membranes with reduced permeability to hydrophobic molecules. Infect. Immun. 37:432-138.
17. Nikaido, H. 1994. Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264:382-388.
18. Okuso, H., D. Ma, and H. Nikaido. 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178:306-308.
19. Orchard, K., and G. E. May. 1993. An EMSA-based method for determining the molecular weight of a protein-DNA complex. Nucleic Acids Res. 21: 3335-3336.
20. Pan, W., and B. G. Spratt. 1994. Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol. Microbiol. 11:769-775.
21. Poole, K., D. E. Heinrichs, and S. Neshat. 1993. Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine. Mol. Microbiol. 10:529-544.
22. Scudamore, R. A., T. J. Beveridge, and M. Goldner. 1979. Penetrability of the outer membrane of Neisseria gonorrhoeae in relation to acquired resistance to penicillin and other antibiotics. Antimicrob. Agents Chemother. 15:820-827.
23. Shafer, W. M., J. T. Balthazar, K. E. Hagman, and S. A. Morse. 1995. Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids. Microbiology 141:907-911.
24. Sparling, P. F., F. A. Sarubbi, and E. Blackman. 1975. Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae. J. Bacteriol. 124:740-749.
25. Suzuki, M., N. Yagi, and M. Gerstein. 1995. DNA recognition and superstructure formation by helix-turn-helix proteins. Protein Eng. 8:329-338.