Structure and function of histone acetyltransferases

Cellular and Molecular Life Sciences

Volumn 58, Issue 5-6, 2001, Pages 693-703

  Marmorstein, R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Chromatin regulation; Gene regulation; GNAT (Gcn5 related acetyltranferases) superfamily; Histone acetyltransferases (HATs); Histone modifications

Indexed keywords

HISTONE ACETYLTRANSFERASE;

ACETYLATION; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBUNIT; GENETIC TRANSCRIPTION; HUMAN; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MODIFICATION; REVIEW; TRANSCRIPTION REGULATION;

EID: 0034968667     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000893     Document Type: Review

References (73)

1. RNA synthesis and histone acetylation during the course of gene activation in lymphocytes
2. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
3. Butyrate suppression of histone deacetylation leads to accumulation of nultiacetylated forms of histones H3 and H4 and increased DNAase I sensitivity of the associated DNA sequences
4. A direct link between core histone acetylation and transcriptionally active chromatin
5. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain
6. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
7. DNA associated with hyper-acetylated histone is preferentially digested by DNasa I
8. Tetrahymena histone acetyltransferase A: A homologue of yeast Gcn5p linking histone acetylation to gene activation
9. Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
10. Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo
11. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
12. The p300/CBP family: Integrating signals with transcription factors and chromatin
13. The CBP co-activator is a histone acetyltransferase
14. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity
15. Steroid receptor co-activator-1 is a histone acetyltransferase
16. Histone deacetylases, transcriptional control and cancer
17. Crystal structure of the nucleosome core particle at 2.8 angstrom resolution
18. Chromatin disruption and modification
19. Roles of histone acetyltransferases and deacetylases in gene regulation
20. Functional similarity and physical association between GCN5 and ADA2-putative transcriptional adaptors
21. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5
22. A p300/CBP-associated factor that competes with the adenoviral E1A oncoprotein
23. Cloning of Drosophila GCN5: Conserved features among metazoan GCN5 family members
24. A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF
25. Acetylation of histones and transcription-related factors
26. ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation
27. Structure and ligand of a histone acetyl-transferase bromodomain
28. Structure and function of a human TAF(II)250 double bromodomain module
29. The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4
30. The SRC family of nuclear receptor coactivators
31. Remembrance of things PAS: Regulation of development by bHLH- PAS proteins
32. DNA-binding motifs from eukaryotic transcription factors
33. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases
34. The translocation t(8;16)(p11, p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB binding protein
35. Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)
36. Mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila
37. Chromodomains are protein-RNA interaction modules
38. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
39. Histone-like TAFs within the PCAF histone acetylase complex
40. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p
41. The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)- FACT complex
42. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines
43. Expanded lysine acetylation specificity of Gcn5 in native complexes
44. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
45. Regulation of E2F1 activity by acetylation
46. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
47. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
48. Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome
49. Acetylation of general transcription factors by histone acetyltransferases
50. Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation
51. Identification of a gene encoding a yeast histone H4 acetyltransferase
52. The major cytoplasmic histone acetyltransferase in yeast: Links to chromatin replication and histone metabolism
53. Nucleosomal DNA regulates the core-histone-binding subunit of the human HAT1 acetyltransferase
54. Purification and characterization of the cytoplasmic histone acetyltransferase B of maize embryos
55. Substrate and sequential site specificity of cytoplasmic histone acetyltransferases of maize and rat liver
56. HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4
57. Human TFIIIC relieves chromatin-mediated repression of RNA polymerase III transcription and contains an intrinsic histone acetyltransferase activity
58. The TFIIIC90 subunit of TAFIIIC interacts with multiple components of the RNA polymerase III machinery and contains histone-specific acetyltransferase activity
59. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that include the yeast SPT10 protein
60. Structure of the histone acetyltransferase Hat1: A paradigm for the GCN5-related N-acetyltransferase superfamily
61. Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase
62. Two crystal structures of N-acetyltransferases reveal a new fold for CoA-dependent enzymes
63. Structure of the Tetrahymna GCN5 bound to coenzyme-A and a histone H3 peptide
64. Crystal structure of the histone acetyltransferase domain of the human P/CAF transcriptional regulator bound to coenzyme-A
65. Crystal structure of yeast Esa1 suggests a unified mechanism of catalysis and substrate binding by histone acetyltransferases
66. Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs
67. Crystal structure of the anti-fungal target N-myristoyltransferase
68. Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator
69. Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily
70. Catalytic mechanism and function of invariant glutamic acid-173 from the histone acetyltransferase GCN5 transcriptional coactivator
71. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia
72. HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF