Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery

Drug Discovery Today

Volumn 5, Issue 1, 2000, Pages 17-24

  Watt, Alan P ^a   Morrison, Denise ^a   Evans, David C ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOMATION; COST EFFECTIVENESS ANALYSIS; DRUG INDUSTRY; DRUG SCREENING; MASS SPECTROMETRY; REVIEW; ROBOTICS; TANDEM MASS SPECTROMETRY;

EID: 0033967953     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(99)01434-8     Document Type: Review

References (49)

1. R.A. Prentis Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964–1985) Br. J. Clin. Pharmacol. 25 1988 387 396
2. J.R. Broach J. Thorner High-throughput screening for drug discovery Nature 384 1996 14 16
3. J.J. Burbaum N.H. Sigal New technologies for high-throughput screening Curr. Opin. Chem. Biol. 1 1997 72 78
4. M.A. Gallop Applications of combinatorial technologies to drug discovery: 1. Background and peptide combinatorial libraries J. Med. Chem. 37 1994 1233 1251
5. E.M. Gordon Applications of combinatorial technologies to drug discovery: 2. Combinatorial organic synthesis, library screening strategies, and future directions J. Med. Chem. 37 1994 1385 1401
6. A.D. Rodrigues Preclinical drug metabolism in the age of high-throughput screening: an industrial perspective Pharm. Res. 14 1997 1504 1510
7. D.A. Smith High throughput drug metabolism Biomed. Health Res. 25 1998 137 143
8. M.H. Tarbit J. Berman High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds Curr. Opin. Chem. Biol. 2 1998 411 416
9. J.D. Gilbert Determination of L-365260, a new cholecystokinin receptor (CCK-B) antagonist, in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry Biol. Mass Spectrom. 21 1992 63 68
10. J.D. Gilbert Determination of L-654066, a new 5α-reductase inhibitor in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry Biol. Mass Spectrom. 21 1992 341 346
11. J.D. Gilbert High-performance liquid chromatography with atmospheric pressure ionization tandem mass spectrometry as a tool in quantitative bioanalytical chemistry ACS Symp. Ser. 619 1996 330 350
12. H.G. Fouda R.P. Schneider Robotics for the bioanalytical laboratory: A flexible system for the analysis of drugs in biological fluids Trends Anal. Chem. 6 1987 139 147
13. H.G. Fouda R.P. Schneider Robotics for the bioanalytical laboratory: Analysis of antipyrine in human serum Am. Clin. Prod. Rev. 7 1988 12 15
14. H.G. Fouda Liquid chromatographic analysis of doxazosin in human serum with manual and robotic sample preparation J. Chromatogr. Sci. 26 1988 570 573
15. J. Henion Sample preparation for LC/MS/MS: analyzing biological and environmental samples Anal. Chem. 70 1998 650A 656A
16. Y-F. Cheng Straightforward solid-phase extraction method for the determination of verapamil and its metabolite in plasma in a 96-well extraction plate J. Chromatogr. A 828 1998 273 281
17. J.P. Allanson The use of automated solid phase extraction in the ‘96 well’ format for high throughput bioanalysis using liquid chromatography coupled to tandem mass spectrometry Rapid Commun. Mass Spectrom. 10 1996 811 816
18. A.C. Harrison D.K. Walker Automated 96-well solid-phase extraction for the determination of doramectin in cattle plasma J. Pharm. Biomed. Anal. 16 1998 777 783
19. S. Pleasance R.A. Biddlecombe Automating ‘96-well’ format solid phase extraction for LC-MS-MS Methodol. Surv. Bioanal. Drugs 25 1998 205 212
20. R.S. Plumb Use of reduced sorbent bed and disk membrane solid-phase extraction for the analysis of pharmaceutical compounds in biological fluids, with applications in the 96-well format J. Chromatogr. B Biomed. Sci. Appl. 694 1997 123 133
21. H. Simpson High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation Rapid Commun. Mass Spectrom. 12 1998 75 82
22. M. Hedenmo B-M. Eriksson Online solid-phase extraction with automated cartridge exchange for liquid chromatographic determination of lipophilic antioxidants in plasma J. Chromatogr. A 661 1994 153 159
23. E. Brandsteterova Automatic solid-phase extraction and high-performance liquid chromatographic determination of quinidine in plasma J. Chromatogr. A 665 1994 101 104
24. A. Marchese Determination of pranlukast and its metabolites in human plasma by LC/MS/MS with PROSPEKT_online solid-phase extraction J. Mass Spectrom. 33 1998 1071 1079
25. D.A. Mcloughlin A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system J. Pharm. Biomed. Anal. 15 1997 1893 1901
26. H.M. Quinn J.J. Takarewski Jr High performance liquid chromatography method and apparatus PCT Int. Appl. WO9716724 1997
27. J. Ayrton The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma Rapid Commun. Mass Spectrom. 11 1997 1953 1958
28. J. Ayrton Optimization and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct online analysis of pharmaceuticals in plasma J. Chromatogr. A 828 1998 199 207
29. S. Steinborner J. Henion Liquid–liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma Anal. Chem. 71 1999 2340 2345
30. K. Kronkvist Automated sample preparation for the determination of budesonide in plasma samples by liquid chromatography and tandem mass spectrometry J. Chromatogr. A 823 1998 401 409
31. V.C.X. Gao Column switching in high-performance liquid chromatography with tandem mass spectrometric detection for high-throughput preclinical pharmacokinetic studies J. Chromatogr. A 828 141–148 1998
32. A. Abd Elbary Agreement between pooled sample technique and trapezoidal rule in determining the bioequivalence of certain metronidazole tablets Bull. Fac. Pharm. 34 1996 203 208
33. K.A. Cox Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats Drug Discovery Today 4 1999 232 237
34. J.D. Gilbert The use of LC-MS-MS for multiple component pharmacokinetic studies in support of drug discovery Methodol. Surv. Bioanal. Drugs 25 1998 235 245
35. L.W. Frick Cassette dosing: Rapid estimation of in vivo pharmacokinetics Med. Chem. Res. 8 1998 472 477
36. F. Beaudry In vivo pharmacokinetic screening in cassette dosing experiments: The use of online Prospekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery Rapid Commun. Mass Spectrom. 12 1998 1216 1222
37. L.W. Frick Cassette dosing: Rapid in vivo assessment of pharmacokinetics Pharm. Sci. Technol. Today 1 1998 12 18
38. M.K. Bayliss L.W. Frick High-throughput pharmacokinetics: Cassette dosing Curr. Opin. Drug Discovery Dev. 2 1999 20 25
39. J. Schmid Automated sample preparation for GC-MS and LC-MS-MS and automated reporting Methodol. Surv. Bioanal. Drugs 25 1998 213 218
40. U. Timm K. Fuchs Concept and specification of LIMS for pharmacokinetic studies Lab. Autom. Inf. Manage. 32 1996 7 22
41. I. Fu Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection J. Pharm. Biomed. Anal. 18 1998 347 357
42. D.L. Buhrman Quantitation of SR 27417 in human plasma using electrospray liquid chromatography–tandem mass spectrometry: A study of ion suppression J. Am. Soc. Mass Spectrom. 7 1996 1099 1105
43. B.K. Matuszewski Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of Finasteride in human plasma at picogram per milliliter concentrations Anal. Chem. 70 1998 882 889
44. R. Bonfiglio The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds Rapid Commun. Mass Spectrom. 13 1999 1175 1185
45. F.E. Kuhlmann Signal enhancement for gradient reverse-phase high-performance liquid chromatography–electrospray ionization mass spectrometry analysis with trifluoroacetic and other strong acid modifiers by postcolumn addition of propionic acid and isopropanol J. Am. Soc. Mass Spectrom. 6 1995 1221 1225
46. B.K. Matuszewski Development of high-performance liquid chromatography–tandem mass spectrometric methods for the determination of a new oxytocin receptor antagonist (L-368899) extracted from human plasma and urine: A case of lack of specificity due to the presence of metabolites J. Chromatogr. B Biomed. Sci. Appl. 716 1998 195 208
47. M. Jemal Y-Q. Xia The need for adequate chromatographic separation in the quantitative determination of drugs in biological samples by high performance liquid chromatography with tandem mass spectrometry Rapid Commun. Mass Spectrom. 13 1999 97 106
48. K.M. Clauwaert Investigation of the quantitative properties of the quadrupole orthogonal acceleration time-of-flight mass spectrometer with electrospray ionisation using 3,4-methylenedioxymethamphetamine Rapid Commun. Mass Spectrom. 13 1999 1540 1545
49. V. De Biasil High throughput liquid chromatography/ mass spectrometric analyses using a novel multiplexed electrospray interface Rapid Commun. Mass Spectrom. 13 1999 1165 1168