E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc

Journal of Virology

Volumn 75, Issue 15, 2001, Pages 7198-7201

  Gewin, L ^a   Galloway, D A ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CORRELATION FUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSCRIPTION; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; WART VIRUS;

CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION; HUMANS; KERATINOCYTES; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; RNA; TELOMERASE;

EID: 0034947881     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.15.7198-7201.2001     Document Type: Article

References (35)

1. Transcriptional repression and activation in the same cell type of the human c-MYC promoter by the retinoblastoma gene protein: Antagonisation of both effects by SV40 T antigen
2. Extension of life-span by introduction of telomerase into normal human cells
3. The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter
4. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
5. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation
6. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
7. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
8. The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest
9. Human papillomavirus type 16 E6-induced degradation of E6Tp1 correlates with its ability to immortalize human mammary epithelial cells
10. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation
11. Viral oncogenes accelerate conversion to immortality of cultured conditionally immortal human mammary epithelial cells
12. Creation of human tumour cells with defined genetic elements
13. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
14. Proteins of the Myc network: Essential regulators of cell growth and differentiation
15. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
16. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
17. Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins
18. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
19. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein
20. Telomerase activation by the E6 gene product of human papillomavirus type 16
21. Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells
22. Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro
23. Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells
24. hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization
25. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein
26. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
27. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
28. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
29. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
30. Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein
31. Myc activates telomerase
32. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
33. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
34. Direct activation of TERT transcription by c-MYC