Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein

Journal of Virology

Volumn 75, Issue 9, 2001, Pages 4467-4472

  Veldman, T ^a   Horikawa, I ^a   Barrett, J C ^a   Schlegel, R ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; TELOMERASE; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE ACTIVATION; GENE INDUCTION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; VIRUS GENE; WART VIRUS;

BINDING SITES; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KERATINOCYTES; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; RNA; TELOMERASE; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; UP-REGULATION;

EID: 0035043423     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.9.4467-4472.2001     Document Type: Article

References (46)

1. Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity
2. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements
3. Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells
4. Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
5. Extension of life span by introduction of telomerase into normal human cells
6. The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter
7. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
8. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
9. The E6 protein of human papillomavirus type 16 functions as a transcriptional repressor in a mechanism independent of the tumor suppressor protein, p53
10. Telomere length regulation
11. Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1
12. Inhibition of telomerase limits the growth of human cancer cells
13. Telomeres shorten during ageing of human fibroblasts
14. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
15. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
16. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
17. Specific association of human telomerase activity with immortal cells and cancer
18. Transactivation of prothymosin alpha and c-myc promoters by human papillomavirus type 16 E6 protein
19. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
20. Telomerase activation by the E6 gene product of human papillomavirus type 16
21. 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO
22. Transcriptional activation by the papillomavirus E6 zinc finger oncoprotein
23. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
24. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes
25. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
26. Telomerase catalytic subunit homologs from fission yeast and human
27. The telomerase reverse transcriptase: Components and regulation
28. Identification of Mad as a repressor of the human telomerase (hTERT) gene
29. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
30. Expression profile of the putative catalytic subunit of the telomerase gene
31. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
32. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
33. Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma
34. Inhibition of serum- and calcium-induced differentiation of human keratinocytes by HPV16 E6 oncoprotein: Role of p53 inactivation
35. The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length
36. E5 oncoprotein mutants activate phosphoinositide 3-kinase independently of platelet-derived growth factor receptor activation
37. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
38. Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer
39. The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene
40. Myc activates telomerase
41. Origin of concatemeric T7 DNA
42. Association of human papillomavirus types 16 and 18 E6 proteins with p53
43. Direct activation of TERT transcription by c-MYC
44. Human papillomaviruses in the pathogenesis of anogenital cancer
45. Viruses in human cancers
46. Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis