Hydrogen peroxide activates NFκB and the interleukin-6 promoter through NFκB-inducing kinase

Antioxidants and Redox Signaling

Volumn 3, Issue 3, 2001, Pages 493-504

  Zhang, J ^a   Johnston, G ^b   Stebler, B ^b   Keller, E T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6;

AGING; ARTICLE; CELL CULTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 0034945361     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/15230860152409121     Document Type: Article

References (62)

1. Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells
2. Reactive oxygen intermediates as second messengers of a general pathogen response
3. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation
4. Oxidative stress and nuclear factor-kappaB activation: A reassessment of the evidence in the light of recent discoveries
5. Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: Evidence against a universal hypothesis involving oxygen radicals
6. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
7. TRAF6 is a signal transducer for interleukin-1
8. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity
9. Association between oxidative stress and cytokine production in nickel-treated rats
10. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
11. CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain
12. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
13. Cytokine expression in hepatocytes: Role of oxidant stress
14. Toxic metals stimulate inflammatory cytokines in hepatocytes through oxidative stress mechanisms
15. GSH transport in mitochondria: Defense against TNF-induced oxidative stress and alcohol-induced defect
16. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
17. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
18. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
19. Tumor necrosis factor-alpha mediated activation of signal transduction cascades and transcription factors in 3T3-L1 adipocytes
20. Nuclear factor kappa B activity in response to oxidants and antioxidants
21. Changes in oxygen-metabolizing enzymes and lipid peroxidation in human erythrocytes as a function of age of donor
22. Inhibition of NFκB activity through maintenance of IκBα levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
23. Molecular and cellular biology of interleukin-6 and its receptor
24. Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression
25. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases
26. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
27. Transcriptional activation and redox regulation of the tumor necrosis factor-alpha promoter in human T cells: Role of the CRE/kappa3 promoter region
28. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
29. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NFκB activation
30. Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates
31. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
32. Do mitochondria produce oxygen radicals in vivo?
33. Oxygen and the control of gene expression
34. 2+ and reactive oxygen intermediates as messengers
35. The ER-overload response: Activation of NF-kappa B
36. Identification of a novel NF-kappaB p50-related protein in B lymphocytes
37. Activation of the human "β2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists
38. A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: Similarities with c-fos gene regulation
39. Identification and characterization of an IkappaB kinase
40. Low levels of reactive oxygen species as modulators of cell function
41. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
42. Cupric ion blocks NF kappa B activation through inhibiting the signal-induced phosphorylation of I kappa B alpha
43. Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells
44. Changes in superoxide radical and lipid peroxide formation in the brain, heart, and liver during the lifetime of the rat
45. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HW-1
46. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation
47. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
48. Regulation of IL6 gene expression
49. Redox signaling and the emerging therapeutic potential of thiol antioxidants
50. Cellular thiols and redox-regulated signal transduction
51. Effects of physical activity on superoxide dismutase, catalase, inorganic peroxides and glutathione in the adult male house fly, Musca domestica
52. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-Jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
53. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
54. Redox regulation of transcriptional activators
55. Oxidants as stimulators of signal transduction
56. Thioredoxin inhibits tumor necrosis factor- or interleukin-1-induced NF-κB activation at a level upstream of NF-κB-inducing kinase
57. Oxidative stress up-regulates IL-8 and TNF-alpha synthesis by human dendritic cells
58. Rel/NF-κB/IκB family: Intimate tales of association and dissociation
59. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
60. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
61. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation
62. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation