Toxic Metals Stimulate Inflammatory Cytokines in Hepatocytes through Oxidative Stress Mechanisms

Toxicology and Applied Pharmacology

Volumn 151, Issue 2, 1998, Pages 359-366

  Dong, Wumin ^a,b   Simeonova, Petia P ^c   Gallucci, Randle ^c   Matheson, Joanna ^c   Flood, Lori ^c   Wang, Shiyi ^c   Hubbs, Ann ^c   Luster, Michael I ^c  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Cadmium; Chemokines; Hep G2; Hepatocytes; Hepatotoxicity; Interleukin 8; Oxidative stress; Reactive oxygen species; Vanadium pentoxide

Indexed keywords

RODENTIA;

ANTIOXIDANT; AUTACOID; CADMIUM CHLORIDE; CYTOKINE; REACTIVE OXYGEN METABOLITE; VANADIUM DERIVATIVE; VANADIUM PENTOXIDE;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHEMOTAXIS; CYTOLOGY; DRUG EFFECT; FISCHER 344 RAT; HUMAN; L CELL; LIVER; METABOLISM; MOUSE; NEUTROPHIL; OXIDATIVE STRESS; RAT; SECRETION;

ANIMALS; ANTIOXIDANTS; CADMIUM CHLORIDE; CELLS, CULTURED; CHEMOTAXIS; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; L CELLS (CELL LINE); LIVER; MICE; MICE, INBRED C57BL; NEUTROPHILS; OXIDATIVE STRESS; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; VANADIUM COMPOUNDS;

EID: 0032137199     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8481     Document Type: Article

References (41)

1. Akerman, P., Cote, P., Yang, S. Q., McClain, C., Nelson, S., Bagby, G. J., and Diehl, A. M. (1992). Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy. Am. J. Physiol. 263, G579-G585.
2. Andus, T., Bauer, J., and Geruk, W. (1991). Effects of cytokines on the liver. Hepatology 13, 364-375.
3. Armendariz-Borunda, J., Seyer. J. M., Postlethwaite, A. E., and Kang, A. H. (1991). Kupffer cells from carbon tetrachloride-injured rat livers produce chemotactic factors for fibroblasts and monocytes: The role of tumor necrosis factor-α. Hepatology 14, 895-900.
4. Aust, S. D., Chignell, C. F., Bray, T. M., Kalyanaraman, B., and Mason, R. P. (1993) Contemporary issues in toxicology: Free radicals in toxicology. Toxicol. Appl. Pharmacol. 120, 168-178.
5. Baggiolini, M., Dewald, B., and Moser, B. (1994). Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55, 97-179.
6. Banerjee, R., Karpen, S., Siekevitz, M., Lengyel, G., Bauer, J., Acs, G. (1989). Tumor necrosis factor-α induces a κB sequence-specific DNA-binding protein in human hepatoblastoma Hep G2 cells. Hepatology 10, 1008-1013.
7. Ben-Baruch, A., Michiel, D. F., and Oppenheim, J. J. (1995). Signals and receptors involved in recruitment of inflammatory cells. J. Biol. Chem. 270, 11703-11706.
8. Beyer, H. S., and Theologides, A. (1993). Tumor necrosis factor-α is a direct hepatocyte mitogen in the rat. Biochem. Mol. Biol. Int. 29, 1-4.
9. Blazka, M. E., Germolec, D. R., Simeonova, P., Bruccoleri, A., Pennypacker, K. R., and Luster, M. I. (1996). Acetaminophen-induced hepatotoxicity is associated with early changes in NF-κB and NF-IL6 DNA binding activity. J. Inflammation 47, 138-156.
10. Blazka, M. E., Wilmer, J. L., Holladay, S. D., and Luster, M. I. (1995). Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol. Appl. Pharmacol. 133, 43-52.
11. Bruccoleri, A., Gallucci, R., Germolec, D. R., Blackshear, P., Simeonova, P., Thurman, R. G., and Luster, M. I. (1997). Induction of early-immediate genes by tumor necrosis factor-α contribute to liver repair following chemical-induced hepatotoxicity. Hepatology 25, 133-141.
12. Comporti, M. (1985). Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest. 53, 599-623.
13. Dargel, R. (1992). Lipid peroxidation: A common pathogenetic mechanism? Exp. Toxicol. Pathol. 44, 169-181.
14. Dinarello, C. A. (1993). Circulating interleukin-1 and tumor necrosis factor antagonists in liver. Hepatology 18, 1132-1138.
15. Feingold, K. R., and Grufeld, C. (1987). Tumor necrosis factor alpha stimulates hepatic lipogenesis in the rat in vivo. J. Clin. Invest. 80, 184-190.
16. Fridovich, I. (1983). Superoxide radical: An endogenous toxicant. Annu. Rev. Pharmacol. Toxicol. 23, 239-257.
17. Ganey, P. E., and Schultze, A. E. (1995). Depletion of neutrophils and modulation of Kupffer cell function in allyl alcohol-induced hepatotoxicity. Toxicology 99, 99-106.
18. Giri, J. G., Robb, R., Wong, W. L., and Horuk, R. (1992). Hep G2 cells predominantly express the "t" type II interleukin 1 receptor (biochemical and molecular characterization of the IL-1 receptor). Cytokine 4, 18-23.
19. Iimuro, Y., Gallucci, R. M., Luster, M. I., Kono, H., and Thurman, R. G. (1997). Antibodies to tumor necrosis factor alpha attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26, 1530-1537.
20. Kayama, F., Yoshida, T., Elwell, M. R., and Luster, M. I. (1995). Role of tumor necrosis factor-α in cadmium-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 131, 224-234.
21. Kreamer, B. L., Staecker, J. L., Norimasa, S., Sattler, G. L., Stephen, H., and Pitot, H. (1986). Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations. In Vitro Cell. Dev. Biol. 22, 201-211.
22. Laskin, D. L. (1990). Nonparenchymal cells and hepatotoxicity. Sen. Liver Dis. 10, 293-304.
23. Lauwerys, R. (1979). Cadmium in man. In Chemistry, Biochemistry and Biology of Cadmium (M. Webb, Ed.), pp. 433, Elsevier/North Holland Biomedical Press, Amsterdam.
24. Liu, J., Kershaw, W. C., Liu, Y. P., and Klaassen, C. D. (1992). Cadmium-induced hepatic endothelial cell injury in inbred strains of mice. Toxicology 75, 51-62.
25. Maltby, J., Wright, S., Bird, G., and Sheron, N. (1996). Chemokine levels in human liver homogenates: Associations between GRO alpha and histopathological evidence of alcoholic hepatitis. Hepatology 24, 1156-1160.
26. Manca, D., Ricard, A. C., Trottier, B., and Chevalier, G. (1991). Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. Toxicology 67, 303-323.
27. Matthews, N., and Neale, M. L. (1987). Cytotoxicity assays for tumor necrosis factor and lymphotoxin. In Lymphokines and Interferons: A Practical Approach (A. J. M. Gearing, A. G. Morris, and M. J. Clemens, Eds.), pp. 221-225. Oxford, IRL Press.
28. McKim, J. M., Jr., Liu, J., Lie, Y. P., and Klaassen, C. D. (1992). Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer and endothelial cells: Their relative ability to express metallothionein. Toxicol. Appl. Pharmacol. 112, 324-333.
29. Nolan, C. V., and Shaikh, Z. A. (1986). The vascular endothelium as a target tissue in acute cadmium toxicity. Life Sci. 39, 1403-1411.
30. Ohsawa, M. (1997). Biomarkers for responses to heavy metals. Cancer Causes & Control 8, 514-517.
31. Oliveira, I. C., Mukaida, N., Matsushima, K., and Vilcek, J. (1994). Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-κB site. Mol. Cell. Biol. 14, 5300-5308.
32. Remick, D. G., and Villareti, L. (1996). Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates. J. Leukocyte Biol. 59, 471-475.
33. Schook, L. B., Lockwood, J. F., Yang, S-D., and Myers, M. J. (1992). Dimethylnitrosamine (DMN)-induced IL-1β, TNF-α and IL-6 inflammatory cytokine expression. Toxicol. Appl. Pharmacol. 116, 110-116.
34. Schreck, R., Albermann, K., and Bauerle, P. A. (1992). Nuclear factor kappa β: An oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radical Res. Commun. 17, 221-237.
35. Seglen, P. O. (1976). Preparation of isolated rat liver cells. Methods Biol. 13, 29-83.
36. Seig, D. J., and Billings, R. E. (1997). Lead/cytokine-mediated oxidative DNA damage in cultured mouse hepatocytes. Toxicol. Appl. Pharmacol. 142, 106-115.
37. Simeonova, P. P., and Luster, M. I. (1996). Asbestos induction of nuclear transcription factors and interleukin 8 gene regulation. Am. J. Respir. Cell Mol. Biol. 15, 787-795.
38. Simeonova, P. P., Toriumi, W., Kommineni, C., Erkan, M., Munson, A. E., Rom, W. N., and Luster, M. I. (1997). Molecular regulation of IL-6 activation by asbestos in lung epithelial cells: Role of reactive oxygen species. J. Immunol. 159, 3921-3928.
39. Thornton, A. J., Strieter, R. M., Lindley, I., Baggiolini, M., and Kunkel, S. L. (1990). Cytokine-induced gene expression of a neutrophil chemotactic factor/IL-8 in human hepatocytes. J. Immunol. 144, 2609-2613.
40. Wenning, R., and Kirsch, N. (1988). Vanadium. In Toxicity of Inorganic Compounds (H. G. Seiler and H. Sigel, Eds.), pp. 749-758. Marcel Dekker, New York.
41. Wong, G. H. W., and Goeddel, D. V. (1988). Induction of manganese superoxide dismutase by tumor necrosis factor: Possible protective mechanisms. Science (Washington, D.C.) 242, 941-944.