The contributions of T-cell anergy to peripheral T-cell tolerance

Immunology

Volumn 103, Issue 3, 2001, Pages 262-269

  Lechler, Robert ^a   Chai, Jian Guo ^a   Marelli Berg, Federica ^a   Lombardi, Giovanna ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR;

APOPTOSIS; CELL ACTIVITY; CELL DIVISION; CELL FUNCTION; CELL STIMULATION; HUMAN; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; APOPTOSIS; CLONAL ANERGY; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS;

EID: 0034931582     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01250.x     Document Type: Review

References (81)

1. Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen
2. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin
3. Th2 cell clonal anergy as a consequence of partial activation
4. Clonal anergy blocks the response to IL-4, as well as the production of IL-2 in dual-producing helper T cell clones
5. + T cell receptor-dependent cytolysis in the absence of interleukin-2 production
6. Multiple levels of peripheral tolerance
7. Reversal of in vitro T cell clonal anergy by IL-2 stimulation
8. + T cells
9. Stimulation of normal inducer T cell clones with antigen presented by purified la molecules in planar lipid membranes: Specific induction of a long-lived state of proliferative non-responsiveness
10. B7, a new member of the 1g superfamily with unique expression on activated and neoplastic B cells
11. Binding of the B cell activation antigen B7 to CD28 costimulate T cell proliferation and interleukin-2 mRNA accumulation
12. Transplantation of anergic histoincompatible bone marrow allografts
13. Models of T cell anergy: Is there a common molecular mechanism?
14. + T cells: Markedly enhanced sensitivity of memory versus naive T cells to peripheral anergy
15. Activation and differentiation requirements of primary T cells in vitro
16. Differences between responses of naïve and activated T cells to anergy induction
17. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor
18. Induction of T -cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
19. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling
20. Partial T cell signalling: Altered phospho-xxx and lack of Zap-70 recruitment in APL-induced T cell anergy
21. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
22. Peptide analogues as a strategy to induce tolerance in T cells with indirect allospecificity
23. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants
24. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
25. Clonal anergy is induced by T cell receptor occupancy in the absence of proliferation
26. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
27. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
28. Essential requirement for major histocompatibility complex in recognition in T cell tolerance induction
29. Human T cells cannot act as autonomous antigen presenting cells but induce tolerance in antigen-specific and alloreactive T cells
30. The B7 adherent molecule is expressed on activated human T cells: Functional involvement in T-T interactions
31. Functional expression of B7/BB1 on activated T lymphocytes
32. B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro
33. Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals
34. Molecular basis of T cell inactivation by CTLA-4
35. CTLA-4 is a second receptor for the B-cell activation antigen B7
36. CTLA-4 can function as a negative regulator of T cell activation
37. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
38. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
39. Loss of CTLA-4 leads to massive lymphoproliferative and fatal multiorgan tissue destruction, revealing a critical negetive regulatory role of CTLA-4
40. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
41. CTLA-4 regulates tolerance induction and T cell differentiation in vivo
42. CTLA-4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
43. The role of CD80, CD86, and CTLA-4 in alloimmune response and the induction of long-term allograft survival
44. + Tcells
45. Induction of T cell anergy in the absence of CTLA-4/B7 interaction
46. Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling
47. + T cells
48. Tolerance, danger, and the extended family
49. Competition for follicular niches excludes self-reactive B cells from the recirculating B-cell repertoire
50. T cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E
51. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction
52. Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self-antigen
53. + T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells
54. + T cells in staphylococcus enterotoxin B-primed mice
55. In vivo induction of anergy in peripheral Vb8+ T cells by staphylococcal enterotoxin B
56. T cell immunity after a viral infection verus T cell tolerance induced by soluble viral peptides
57. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance
58. + T cells
59. Interleukin-10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
60. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
61. + T cells persist in vivo following induction of peripheral tolerance
62. Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance
63. B7 but not intercellular adhesion molecule-1 prevents the induction of human alloantigen-specific tolerance
64. + T cells and deletion of CD45RA cells
65. Gamma-interferon treated renal tubular epithelial cells induce allospecific tolerance
66. Detection of donor-specific hyporesponsiveness following late failure of human renal allografts
67. Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in human
68. The role of the allograft in the induction of donor-specific T cell hyporesponsiveness
69. The role of T cell anergy in the maintenance of donor-specific hyporesponsiveness in renal transplant recipients
70. Anergic T cells act as suppressor cells in vitro
71. Anergic T cells effect linked suppression
72. Monoclonal antibodies as agents to reinduce tolerance in autoimmunity
73. Anergic T cells act as suppressor cells in vitro and in vivo
74. Anergic T cells inhibit the antigen-presenting function of dendritic cells
75. T cell-mediated maintenance of natural self-tolerance: Its break-down as possible cause of various autoimmune diseases
76. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
77. - immunoregulatory T cells is antigen nonspecific
78. Regulatory T cells: Key controllers of immunologic self-tolerance
79. The third function of the thymus
80. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
81. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25 (+) CD4 (+) regulatory cells that control intestinal inflammation