The role of the allograft in the induction of donor-specific T cell hyporesponsiveness

Transplantation

Volumn 72, Issue 3, 2001, Pages 480-485

  Baker, Richard J ^a   Hernandez Fuentes, Maria P ^a   Brookes, Paul A ^a   Chaudhry, Afzal N ^a   Lechler, Robert I ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 2;

ARTICLE; CELL POPULATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CYTOKINE RELEASE; FLOW CYTOMETRY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; MEMORY CELL; PARENCHYMA; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035881969     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200108150-00020     Document Type: Article

References (37)

1. Sequential analysis of HLA-class II antigen expression in human renal allografts. Induction of tubular class II antigens and correlation with clinical parameters
2. Thyroid allograft immunogenicity is reduced after a period in organ culture
3. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells
4. Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells
5. Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance
6. Human CD4+ T cells proliferate to HLA-DR+ allogeneic vascular endothelium. Identification of accessory interactions
7. Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells
8. Detection of donor-specific hyporesponsiveness following late failure of human renal allografts
9. Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans
10. Donor-specific hyporeactivity after liver transplantation: Prominent decreases in donor-specific cytotoxic T lymphocyte precursor frequencies independent of changes in helper T lymphocyte precursor frequencies or suppressor cell activity
11. Longitudinal study of the frequency of cytotoxic T cell precursors in kidney allograft recipients
12. Evidence that human cardiac allograft acceptance is associated with a decrease in donor-reactive helper T lymphocytes
13. In vitro responses of human CD45RObrightRA- and CD45RO-RAbright T cell subsets and their relationship to memory and naive T cells
14. Naive and memory T cells show distinct pathways of lymphocyte recirculation
15. Lymphocyte homing and homeostasis
16. Likelihood-based methods for bias reduction in limiting dilution assays
17. Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: Implications for differential CD45 expression in T cell memory formation
18. Structural aspects of allorecognition
19. Lymphocyte migration into tissue: The paradigm derived from CD4 subsets
20. Predominant infiltration of rejecting human renal allografts with T cells expressing CD8 and CD45RO
21. Conditions that induce tolerance in mature CD4+ T cells
22. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
23. Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients
24. Donor-recipient microchimerism is not required for tolerance induction following recipient pretreatment with donor-specific transfusion and anti-CD4 antibody. Evidence of a clear role for short-term antigen persistence
25. Cell migration, chimerism, and graft acceptance
26. Reversal of in vitro T cell clonal anergy by IL-2 stimulation
27. Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice
28. Histological findings in early routine biopsies of stable renal allograft recipients
29. CD45RA+ and CD45RO+ T cells differ in susceptibility to cyclosporin A mediated inhibition of interleukin-2 production
30. Clinical outcome of renal transplantation. Factors influencing patient and graft survival
31. Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection
32. Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection
33. Abrogation of chronic rejection in a murine model of aortic allotransplantation by prior induction of donor-specific tolerance
34. Significant frequencies of T cells with indirect anti-donor specificity in heart graft recipients with chronic rejection
35. Indirect recognition of donor HLA class I peptides in lung transplant recipients with bronchiolitis obliterans syndrome
36. Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction
37. Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts