Antigen Presentation by Epithelial Cells Induces Anergic Immunoregulatory CD45RO+ T Cells and Deletion of CD45RA+ T Cells

Journal of Immunology

Volumn 159, Issue 12, 1997, Pages 5853-5861

  Marelli Berg, Federica M ^a   Weetman, Anthony ^b   Frasca, Loredana ^a   Deacock, Sarah J ^a   Imami, Nesrina ^a   Lombardi, Giovanna ^a   Lechler, Robert I ^a,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; B7 ANTIGEN; CD45 ANTIGEN; FAS ANTIGEN; GAMMA INTERFERON; HLA ANTIGEN CLASS 2; INTERLEUKIN 2; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL; ANTIGEN PRESENTATION; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CLONAL ANERGY; COCULTURE; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; HUMAN; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INTERPHASE; KIDNEY TUBULE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYROID GLAND;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; ANTIGENS, CD45; ANTIGENS, CD80; ANTIGENS, CD95; CELL LINE; CELLS, CULTURED; CLONAL ANERGY; CLONAL DELETION; COCULTURE TECHNIQUES; EPITHELIAL CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNIZATION; INTERFERON TYPE II; INTERLEUKIN-2; INTERPHASE; ISOANTIGENS; KIDNEY TUBULES; LYMPHOCYTE ACTIVATION; MICE; RECOMBINANT PROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; THYROID GLAND;

EID: 0031573671     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Visscher, D., J. Carey, H. Ho, N. Turza, W. Kupin, K. K. Venkat, and R. Zarbo. 1991. Histologic and immunophenotypic evaluation of pretreatment renal biopsies on OKT3-treated allograft rejections. Transplantation 51:1023.
2. Hytiroglou, P., R. Lee, K. Sharma, N. D. Theise, M. Schwartz, C. Miller, and S. N. Thung. 1993. FK506 versus cyclosporine as primary immunosuppresive agent for orthotopic liver allograft recipients: histologic and immunopathologic observations. Transplantation 56:1386.
3. Bottazzo, G. F., R. Pujol-Borrell, T. Hanafusa, and M. Feldmann. 1983. Role of aberrant HLA-DR expression and antigen expression in induction of endocrine autoimmunity. Lancet 2:1115.
4. Asakawa, H., T. Hanafusa, K. Kuma, N. Kono, and S. Tarui. 1992. Function of DR-positive thyrocytes from patients with Graves' disease: quantitative analysis of thyroid peroxidase content by fluorescent photometry. J. Clin. Endocrinol. Metab. 74:614.
5. Coleman, N., and M. A. Stanley. 1994. Analysis of HLA-DR expression on keratinocytes in cervical neoplasia. Int. J. Cancer 56:314.
6. Brookes, S. M., E. J. Price, P. J. Venables, and R. N. Maini. 1995. Interferon-gamma and epithelial cell activation in Sjogren's syndrome. Br. J. Rheumatol. 34:226.
7. Londei, M., G. F. Bottazzo, and M. Feldmann. 1985. Human T cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science 228:85.
8. Londei, M., J. R. Lamb, G. F. Bottazzo, and M. Feldmann. 1984. Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. Nature 312:639.
9. Weetman, A. P., D. J. Volkman, K. D. Burman, J. B. Marfolick, P. Petrick, B. D. Weintraub, and A. S. Fauci. 1986. The production and characteristics of thyroid-derived T cell lines in Graves' disease and Hashimoto's thyroiditis. Clin. Immunol. Immunopathol. 39:131.
10. Dayan, C. M., M. Londei, A. E. Corcoran, B. Grubeck-Loebenstein, R. F. L. James, B. Rapoport, and M. Feldmann. 1991. Autoantigen recognition by thyroid-infiltrating T cells in Graves' disease. Proc. Natl. Acad. Sci. USA 88: 7415.
11. Gaspari, A. A., M. K. Jenkins, and S. I. Katz. 1988. Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific Th1 clones. J. Immunol. 141:2216.
12. Bal, V., A. McIndoe, G. Denton, D. Hudson, G. Lombardi, J. Lamb, and R. I. Lechler. 1990. Antigen presentation by keratinocytes induces tolerance in human T cells. Eur. J. Immunol. 20:1893.
13. Markman, J., D. Lo, A. Naji, R. D. Palmiter, R. L. Brinster, and E. Herber-Katz. 1988. Antigen-presenting cell function of class II MHC-expressing pancreatic beta cells. Nature 336:476.
14. Lombardi, G., K. Arnold, J. Uren, F. Marelli-Berg, R. E. G. Hargreaves, N. Imami, A. Weetman, and R. I. Lechler. 1997. Antigen presentation by interferon-γ-treated thyroid follicular cells inhibits interleukin-2 (IL-2) and supports IL-4 production by B7-dependent human T cells. Eur. J. Immunol. 27:62.
15. Tan, P., C. Anasetti, J. A. Hansen, J. Melrose, M. Brunvand, J. Bradshaw, J. A. Ledbetter, and P. S. Linsley. 1993. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177:165.
16. Boussiotis, V. A., G. J. Freeman, G. Gray, J. G. Gribben, and L. M. Nadler. 1993. B7 but not intercellular adhesion molecule-1 prevents the induction of human alloantigen-specific tolerance. J. Exp. Med. 178:1753.
17. b in the liver. Eur. J. Immunol. 25:1932.
18. Schönrich, G., U. Kalinke, F. Momburg, M. Malissen, A. M. Schmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Downregulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65:293.
19. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of 'tolerance' and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
20. Fermand, J. P., A. Chevalier, and J. C. Brouet. 1986. Characterization of a monoclonal antibody recognizing a monomorphic determinant of the alpha chain of Class II DQ antigens. Scand. J. Immunol. 24:313.
21. Smith, S. H., M. H. Brown, D. Rowe, R. E. Callard, and P. L. C. Beverley. 1986. Functional subset of human helper-inducer cells denned by a new monoclonal antibody, UCHL 1. Immunology 58:63.
22. Munro, C. S., D. A. Campbell, R. M. Dubois, D. N. Mitchell, P. J. Cole, and L. W. Poulter. 1988. Suppression associated lymphocyte markers in lesions of sarcoidosis. Thorax 43:471.
23. Ramsdell, F., M. S. Seam, R. E. Miller, T. W. Tough, M. R. Alderson, and D. H. Lynch. 1994. gld/gld mice are unabe to express functional ligand for Fas. Eur. J. Immunol. 24:928.
24. Weetman, A. P., D. J. Volkman, K. D. Burman, T. I. Gerrard, and A. S. Fauci. 1985. The in vitro regulation of human thyrocyte HLA-DR antigen expression. J. Clin. Endocrinol. Metab. 61:817.
25. Galvin, F., G. J. Freeman, Z. Razi-Wolf, W. Hall, Jr., B. Benacerraf, L. Nadler, and H. Reiser. 1992. Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation. J. Immunol. 149:3802.
26. Liu, Y., and C. A. Janeway, Jr. 1992. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. Proc. Natl. Acad. Sci. USA 89:3845.
27. + T cells by delivery of the B7 costimulatory signal on bystander antigen-presenting cells (trans-costimulation). Eur. J. Immunol. 24:859.
28. Lamb, J. R., E. D. Zanders, W. Sewell, M. J. Crumpton, M. Feldmann, and M. J. Owen. 1987. Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways. Eur. J. Immunol. 17:1641.
29. De Silva, D. R., K. B. Urdahl, and M. K. Jenkins. 1991. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147:3261.
30. + T lymphocytes in acute infectious mononucleosis supporting their susceptibility to programmed cell death. Blood 82:521.
31. Akbar, A. N., N. Borthwick, M. Salmon, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pett, J. E. Grundy, and G. Janossy. 1993. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections: the role of apoptosis in T cell memory. J. Exp. Med. 178:427.
32. Lynch, D. H., F. Ramsdell, and M. R. Alderson. 1995. Fas and FasL in the homeostatic regulation of immune responses. Immunol. Today 16:569.
33. L. Immunity 3:87.
34. Noel, P. J., L. H. Boise, J. M. Green, and C. B. Thompson. 1996. CD28 co-stimulation prevents cell death during primary T cell activation. J. Immunol. 157:636.
35. Boise, L. H., P. J. Noel, and C. B. Thompson. 1995. CD28 and apoptosis. Curr. Opin. Immunol. 7:620.
36. Lombardi, G., S. Sidhu, R. Batchelor, and R. I. Lechler. 1994. Anergic T cells as suppressor cells in vitro. Science 264:1587.
37. Lechler, R. I., and J. R. Batchelor. 1982. Restoration of immunogenicity to passenger cell-depleted kidney allograft by the addition of donor strain dendritic cells. J. Exp. Med. 155:31.
38. Hall, B., M. Jelbart, K. Gurleyand, and S. E. Dorsch. 1985. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine: mediation of specific suppression by T helper/inducer cells. J. Exp. Med. 162:1683.
39. Deacock, S., and R. I. Lechler. 1992. Positive correlation of T cell sensitisation with frequencies of alloreactive T helper cells in chronic renal failure patients. Transplantation 54:338.
40. Mason, P. D., C. M. Robinson, and R. I. Lechler. 1996. Detection of donor-specific hyporesponsiveness following late failure of human renal allograft. Kidney Int. 50:1019.
41. Brent, I., T. Horsburgh, and P. J. Wood. 1980. Induction of suppressor cells and allograft tolerance. Transplant. Proc. 12:464.
42. Marquet, R. L., and G. A. Heyskek. 1981. Induction of suppressor cells by donor-specific blood transfusions and heart transplant in rats. Transplantation 31:272.
43. Kovacs, B., and G. C. Tsokos. 1995. Cross-linking of the Fas/APO antigen suppresses the CD3-mediated signal transduction events in human T lymphocytes. J. Immunol. 155:5543.
44. Alderson, M. R., R. J. Armitage, E. Maraskowsky, T. W. Tough, E. Roux, K. Schooley, F. Ramsdell, and D. H. Lynch. 1993. Fas transduces signals in normal human T lymphocytes. J. Exp. Med. 178:2231.
45. Klas, K., K. M. Debatin, R. Jonker, and P. H. Krammer. 1993. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 5:625.
46. Miyawaki, T., T. Uehara, R. Nibu, T. Tsuji, A. Yachie, S. Yonehara, and N. Taniguchi. 1992. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol. 149:3753.
47. Griffith, T. S., T. Brunner, S. M. Fletcher, D. R. Green, and T. A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270: 1189.
48. Bellgrau, D., D. Gold, H. Selawry, J. Moore, A. Franzusoff, and R. C. Duke. 1995. A role for CD95 ligand in preventing graft rejection. Nature 377:630.
49. Giordano, C., G. Stassi, R. De Maria, M. Todaro, P. Richiusa, G. Papoff, G. Ruberti, M. Bagnasco, R. Testi, and A. Galluzzo. 1997. A potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science 275:960.
50. Suda, T., M. Tanaka, K. Miwa, and S. Nagata. 1996. Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand. J. Immunol. 157:3918.
51. Van Parijs, L., A. Ibraghimov, and A. K. Abbas. 1996. The roles of Costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4:321.
52. Sperling, A. I., and J. A. Bluestone. 1996. The complexities of T-cell co-stimulation: CD28 and beyond. Immunol. Rev. 153:155.
53. Sytwu, H.-K., R. S. Liblau, and H. O. McDevitt. 1996. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 5:17.
54. Metzler, B., and D. C. Wraith. 1993. Inhibition of experimental autoimmune encephalomyelitis by inhalation but no oral administration of the encephalitogenic peptide: influence of MHC binding affinity. Int. Immunol. 5:1159.
55. Qin, S., S. P. Cobbold, H. Pope, J. Elliot, D. Kioussis, J. Davies, and H. Waldmann. 1993. "Infectious" transplantation tolerance. Science 259:974.
56. Rocha, B., A. Grandien, and A. A. Freitas. 1995. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181:993.
57. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991.