Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals

Journal of Immunology

Volumn 156, Issue 8, 1996, Pages 2769-2775

  Lombardi, Giovanna ^a   Hargreaves, Russell ^a   Sidhu, Sid ^a   Imami, Nesrina ^a   Lightstone, Liz ^a   Fuller Espie, Sherry ^a   Ritter, Mary ^a   Robinson, Peter ^b   Tarnok, Attila ^b   Lechler, Robert ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b Clinical Sciences Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; EXTRACELLULAR SPACE; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; SECRETION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; B-LYMPHOCYTES; CALCIUM; CELL LINE; EXTRACELLULAR SPACE; HUMANS; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0030584802     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Linsley, P. S., W Brady, L. Grosmaire, A Aruffo, N K Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and IL-2 mRNA accumulation. J. Exp. Med. 173-721.
2. Schwartz R. H 1992 Costimulation of T lymphocytes, the role of CD28, CTI.A4, and B7/BB1 in interleukin-2 production and immunotherapy Cell 71:1065.
3. Jenkins, M. K., D. M. Pardoll, J. Mizuguchi, H. Quill, and R. H. Schwartz. 1987. T-cell unresponsiveness in vivo and in vitro. fine specificity of induction and molecular characterization of the unresponsive state. Immunol. Rev. 95:113
4. Quill, H., and R H. Schwartz 1987. Stimulation of normal inducer T cell clones with antigen presented by purified la molecules in planar lipid membranes: specific induction of a long-lived state of proliferate non-responsiveness J. Immunol 138.3704.
5. Jenkins, M K., and R. H. Schwartz 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 161.302.
6. Jenkins, M. K., D. M. Pardoll, J. Mizuguchi, T M. Chused, and R H Schwartz 1987. Molecular events in the induction of a nonresponsive state in IL-2 producing helper T-lymphocyte clones Proc. Natl. Acad. Sci. USA 84:5409.
7. Muller, D L., M. K. Jenkins, and R H Schwartz 1989. An accessory cell-derived costimulatory signal acts independently of protein kinase C actuation to allow T cell proliferation and prevent the induction of unresponsiveness. J Immunol. 142:2617
8. Stoan-Lancaster, J., B. D. Evavold, and P M. Allen 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells Nature 363:156
9. De Magistris, M . J Alexander, M. Coggeshall, A. Altman, F. C Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as anatagonists of the T cell receptor. Cell 68.625.
10. Racioppi, L., F. Ronchese, L A. Matis, and R N Germain 1993 Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent mitracellular signaling J. Exp. Med. 177 1047.
11. Ruppert, J . J. Alexander, K. Snoke, M Coggeshall, E. Herbert, D. McKenzie, H. M Grey, and A. Sette. 1993. Effect of T-cell receptor antagonism on inter action between T cells and antigen-presenting cells and on T-cell signaling events. Proc Natl Acad. Sci USA 90.2671.
12. Gajewski, T. S. Schell, G Nau, and F. Fitch. 1989. Regulation of T-cell activation, differences among T-cell subsets Immunol Rev 111.79.
13. Gajewski, T., S. Schell, and F Fitch. 1990 Evidence implicating utilization of different T cell receptor-associated signaling pathways by Th1 and Th2 clones J Immunol. 144:4110.
14. Markman, J., D. Lo, A Naji, R D. Palmiter, R. L. Brinster, and E. Herber-Katz, 1988. Antigen-presenting cell function of class II MHC-expressing pancreatic beta cells Nature 336:476.
15. Gaspari, A. A. M K. Jenkins, and S. I. Katz. 1988. Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific Th1 clones. J. Immunol. 141:2216.
16. Bal V., A. McIndoe, G. Demon, D. Hudson, G. Lombardi, J. Lamb, and R. I. Lechler 1990. Antigen presentation by keratinocytes induces tolerance in human T cells. Eur. J Immunol 20:1893.
17. Lanzavecchia, A., E. Roosnech, T. Gregory, P. Berman, and S. Abrignam. 1988. T cells can present antigens such as HIV gp120 targeted to their own surface molecules. Nature 334:530
18. Hewitt, C. R., and M Feldmann. 1989. Human T cell clones present antigen. J. Immunol. 143.762
19. Barnaba, V . C. Watts, M. de Boer, P Lane, and A. Lanzavecchia. 1994 Professional presentation of antigen by activated human T cells. Eur. J. Immunol. 24:71.
20. Salcmi, S., A. P Caporossi, L. Boffa, M. G. Longobardi, and V. Barnaba. 1995. HIVgp120 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processing J. Exp. Med. 181:2253
21. Lamb, J. R., B. J. Skidmore, N. Green, J. M. Chiller, and M. Feldman. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin J Exp. Med. 157:1434.
22. Sidhu, S , S. Deacock, V. Bal, J. R. Batchelor, G. Lombardi, and R. I. Lechler. 1992. Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells. J Exp Med. 176:875.
23. La Salle, J. M , P. J Tolentino, G J. Freeman, L. M. Nadler, and D. A. Hafler 1992. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J. Exp. Med. 176:177
24. Wyss-Coray, T., C Brander, K. Fruting, and W J. Pichler. 1992. Discrimination of human CD4 T cell clones based on their reactivity with antigen-presenting T cells. Eur. J. Immunol 22:2295.
25. Randall Chu, N , S. Quarantino, M. Feldmann, and M. Londei 1995. Comparison of peptide and superantigen-induced anergy in a peptide-specific polyclonal human T cell line Int Immunol 7:57.
26. Lombardi, G., S. Sidhu, T. Dodi, R Batchelor, and R. Lechler. 1994. Failure of correlation between B7 expression and activation of interleukin-2-secreting T cells. Eur. J. Immunol. 24:523
27. Lechler, R I., S. Sidhu, S. Deucock, J. R. Batchelor, and G Lombardi. 1993. Antigen presentation by T cells - a route to tolerance. Transplant Sci. 3:6.
28. Sansom, D. M., and N. D Hall. 1993. B7/BB1. the ligand for CD28, is expressed on repeatedly actived human T cells in vitro Eur. J. Immunol 23:295.
29. Azuma, M., H. Yssel, J. H Phillips, H. Spits, and L. L. Lanier. 1992. Functional expression of B7/BB1 on activated T lymphocytes. J. Exp. Med. 177:845.
30. Hu-Li, J., J. Ohara, C Watson, W. Tsang, and W. E. Paul. 1989 Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J. Immunol. 142:800
31. 2+ indicators with greatly unproved fluorescence properties. J. Biol. Chem. 260:3440.
32. Szollosi, J., B G. Feuerstein, W C Hyun, M. K. Das, and L. J. Marton. 1991. Attachment of A172 human glioblastoma cells affects calcium signaling a comparison of image cytometry. flow cytometry, and spectrofluorometry. Cytometry 12:707.
33. Imami, N., M. Larché, and M A. Ritter. 1994. Inhibition of alloreactivity by monoclonal antibody MR6: differential effects on IL-2- and IL-4-producing human T cells. Int Immunol. 6:1575.
34. Jenkins, M K , C. Chen, G Jung, D. L. Mueller, and R. H. Schwartz 1990 Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody J Immunol. 144:16.
35. Kubin, M., M Kamoun, and G Trinchieri, 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp Med 180 211.
36. Murphy, E E., G Terres, S E Macatoma, C. S. Hsieh, J. Mattson, L Lanier, M Wysocka, G. Trinchieri, K, Murphy, and A. O'Garra 1994. B7 and Interleukin-12 cooperate for proliferation and inteferon γ production by mouse T helper clones that are unresponsive to B7 costimulation J. Exp. Med. 180:223
37. Evavold, B D , and P M. Allen. 1991 Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand Science 252:1308
38. Brown, J. H , T S. Jardetzky, J C Gorga, L. J. Stern, R. G. Urban, J L. Strominger, and D C Wiley. 1994. Three dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364:33
39. Jameson, S C , and M. J Bevan 1995 T cell receptor antagonists and partial agonists. Immunity 2:1.
40. Gajewski T. F., D W. Lantki, R. Stack, and F W Futch 1994. "Anergy" of ThO helper T lymphocytes induces downregulation of Th1 characteristics and a transition to a Th2-like phenotype J. Exp Med. 179:481
41. +; Th1 but not Th2 cytokine responses Int Immunol. 6:721