Dissociation of T Cell Anergy from Apoptosis by Blockade of Fas/Apo-1 (CD95) Signaling

Journal of Immunology

Volumn 158, Issue 7, 1997, Pages 3099-3107

  Hargreaves, Russell G ^a   Borthwick, Nicola J ^b   Montani, Maria Saveria Gilardini ^c   Piccolella, Enza ^d   Carmichael, Paul ^a   Lechler, Robert I ^a   Akbar, Arne N ^b   Lombardi, Giovanna ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF TUSCIA   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING ANTIBODY; FAS ANTIGEN; FAS LIGAND; FASLG PROTEIN, HUMAN; MEMBRANE PROTEIN; PEPTIDE;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; BINDING COMPETITION; CELL SURVIVAL; CLONAL ANERGY; DOSE RESPONSE; HUMAN; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIBODIES, BLOCKING; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD95; APOPTOSIS; BINDING, COMPETITIVE; CELL SURVIVAL; CLONAL ANERGY; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FAS LIGAND PROTEIN; HUMANS; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; PEPTIDES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0031111910     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. + thymocytes. Nature 333:742.
2. lo thymocytes in vivo. Science 250: 1720.
3. van Parijs, L., and A. K. Abbas. 1996. Role of Fas-mediated cell death in the regulation of immune responses. Curr. Opin. Immunol. 8:355.
4. Akbar, A. N., N. Borthwick, M. Salmon, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pett, J. E. Grundy, and G. Janossy. 1993. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections: the role of apoptosis in T cell memory. J. Exp. Med. 178:427.
5. Debatin, K. M., D. Suss, and P. H, Krammer. 1994. Differential expression of APO-1 on human thymocytes: implications for negative selection? Eur. J. Immunol. 24:753.
6. Ashwell, J. D., D. L. Longo, and S. H. Bridges. 1987. T-cell tumour elimination as a result of T-cell receptor-mediated activation. Science 237:61.
7. Russell, J. H., C. L. White, D. Y. Loh, and P. Meleedy-Rey. 1991. Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc. Natl. Acad. Sci. USA 88:2751.
8. + T cells. J. Immunol. 146:35.
9. Meyaard, L., S. A. Otto, R. R. Jonker, M. J. Mijnster, R. P. M. Keet, and F. Miedema. 1992. Programmed death of T Cells in HIV-1 infection. Science 257:217.
10. + cells of the CD4 and CD8 lineages. AIDS 7:613.
11. Russell, J. H. 1995. Activation-induced death of mature T cells in the regulation of immune responses. Curr. Opin. Immunol. 7:382.
12. Boise, L. H., P. J. Noel, and C. B. Thompson. 1995. CD28 and apoptosis. Current Opin. Immunol. 7:620.
13. Akbar, A. N., N. J. Borthwick, R. G. Wickremasinghe, P. Panayiotidis, D. Pilling, M. Bofill, S. Krajewski, J. C. Reed, and M. Salmon. 1996. Interleukin-2 receptor common γ-chain signalling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xs) gene expression. Eur. J. Immunol. 26:294.
14. Mor, F., and I. R. Cohen. 1996. IL-2 Rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. J. Immunol. 156:515.
15. Itoh, N., Y. Tsujimoto, and S. Nagata. 1993. Effect of bcl-2 on Fas antigen-mediated cell death. J. Immunol. 151:621.
16. Jaattela, M., M. Benedict, M. Tewari, J. A. Shayman, and V. M. Dixit. 1995. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene 10:2297.
17. Strasser, A., A. W. Harris. D. C. S. Huang, P. H. Krammer, and S. Cory. 1995. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14:6136.
18. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
19. Jenkins, M. K., C. Chen, G. Jung, D. L. Mueller, and R. H. Schwartz. 1990. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol. 144: 16.
20. Bal, V., A. McIndoe, G. Denton, D. Hudson, G. Lombardi, J. Lamb, and R. Lechler. 1990. Antigen presentation by keratinocytes induces tolerance in human T cells. Eur. J. Immunol. 20:1893.
21. Warrens, A. N., J. Y. Zhang, S. Sidhu, D. J. Watt, G. Lombardi, C. A. Sewry. and R. I. Lechler. 1994. Myoblasts fail to stimulate T cells but induce tolerance. Int. Immunol. 6:847.
22. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
23. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signalling: altered phospho-ξ and lack of Zap-70 recruitment in APL-induced T cell anergy. Cell 79:913.
24. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ξ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
25. DeSilva, D. R., K. B. Urdahl, and M. K. Jenkins. 1991. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147:3261.
26. Lamb, J. R., B. J. Skidmore, N. Green, J.M. Chiller, and M. Feldman. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza haemagglutinin. J. Exp. Med. 157:1434.
27. Sidhu, S., S. Deacock, V. Bal, J. R. Batchelor, O. Lombardi, and R. I. Lechler. 1992. Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells. J. Exp. Med. 176:875.
28. Wyss-Coray, T., C. Brander, K. Frutig, and W. J. Pichler. 1992. Discrimination of human CD4 T cell clones based on their reactivity with antigen-presenting T cells. Eur. J. Immunol. 22:2295.
29. LaSalle, J. M., P. J. Tolentino, G. J. Freeman, L. M. Nadler, and D. A. Hafler. 1992. Early signalling defects in human T cells anergized by T cell presentation of autoantigen. J. Exp. Med. 176:177.
30. Lombardi, G., S. Sidhu, R. Batchelor, and R. Lechler. 1994. Anergic T cells act as suppressor cells in vitro. Science 264:1587.
31. Alferink, J., B. Schittek, G. Schonrich, G. J. Hammerling, and B. Arnold. 1995. Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. Int. Immunol. 7:331.
32. + T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J. Immunol. 151:7233.
33. Van Parijs, L., A. Ibraghimov, and A. K. Abbas. 1996. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4:321.
34. Lombardi, G., S. Sidhu, T. Dodi, R. Batchelor, and R, Lechler. 1993. Failure of correlation between B7 expression and activation of interleukin-2-secreting T cells. Eur. J. Immunol. 24:523.
35. Lombardi, G., R. Hargreaves, S. Sidhu, N. Imami, L. Lightstone, S. Fuller-Espie, M. Ritter, P. Robinson, A. Tarnock, and R. Lechler. 1996. Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals. J. Immunol. 156:2769.
36. Ramsdell, F., M. S. Seaman, R. E. Miller, T. W. Tough, M. R. Alderson, and D. H. Lynch. 1994. gld/gld mice are unable to express functional ligand for Fas. Eur. J. Immunol. 24:928.
37. Marelli-Berg, F. M., R. E. G. Hargreaves, P. Carmichael, A. Dorling, G. Lombardi, and R. I. Lechler. 1996. Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells. J. Exp. Med. 183:1603.
38. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extract. Anal. Biochem. 162: 156.
39. Del Bino, G., and Z. Darzynkiewicz. 1991. Camptothecin, teniposide, or 4′-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in S phase of HL-60 cells. Cancer Res. 51:1165.
40. Boehme, S. A., and M. J. Lenardo. 1993. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur. J. Immunol. 23:1552.
41. Razvi, E. S., and R. M. Welsh. 1993. Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency. J. Virol. 67:5754.
42. Alderson, M. R., R. J. Armitage, E. Maraskovsky, T. W. Tough, E. Roux, K. Schooley, F. Ramsdell, and D. H. Lynch. 1993. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178:2231.
43. Lamb, J. R., E. D. Zanders, W. Sewell, M. J. Crumpton, M. Feldmann, and M. J. Owen. 1987. Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways. Eur. J. Immunol. 17:1641.
44. Qin, S., S. P. Cobbold, H. Pope, J. Elliot, D. Kioussis, J. Davies, and H. Waldmann. 1993. "Infectious" transplantation tolerance. Science 259:974.