Aliphatic N-Methylpropargylamines: Monoamine Oxidase-B Inhibitors and Antiapoptotic Drugs

Advances in Pharmacology

Volumn 42, Issue C, 1997, Pages 308-311

  Boulton, Alan A ^a   Yu, Peter H ^a   Davis, Bruce A ^a   Paterson, I Alick ^a   Li, Xi Min ^a   Juorio, Augusto V ^a   Durden, David A ^a   Dyck, Lillian E ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0004479609     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60751-6     Document Type: Article

References (7)

1. Yu P.H., Davis B.A., and Boulton A.A. Aliphatic propargylamines: Potent, selective, irreversible monoamine oxidase B inhibitors. J. Med. Chem. 35 (1992) 3705-3713
2. Yu P.H., Davis B.A., and Boulton A.A. Effect of structural modification of alkyl N-propargylamines on the selective inhibition of monoamine oxidase B activity. Biochem. Pharmacol. 46 (1993) 753-757
3. Yu P.H., Davis B.A., Zhang X., Zuo D.M., Fang J., Lai C.T., Li X.M., Paterson I.A., and Boulton A.A. Neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines: New MAO-B inhibitors without amphetamine-like properties. Prog. Brain Res. 106 (1995) 113-121
4. Tatton W.G., Ju W.Y.L., Holland D.P., Tai C., and Kwan M. (-)Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J. Neurochem. 63 (1994) 1572-1575
5. Paterson I.A., Barber A.J., Gelowitz D.L., and Voll C.C. (-)Deprenyl reduces delayed neuronal death of hippocampal pyramidal cells. Neurosci. Biobehav. Res. (1996) (in press)
6. Zhang X., Boulton A.A., and Yu P.H. Expression of HSP70 and limbic seizure-induced neuronal death in the rat brain. Eur. J. Neurosci. 8 (1996) 1432-1440
7. Li X.-, Juorio M.A.V., and Boulton A.A. Some new mechanisms underlying the actions of (-)deprenyl: Possible relevance to neurodegeneration. Prog. Brain Res. 106 (1995) 99-112