Erythropoietin induction in Hep3B cells is not affected by inhibition of heme biosynthesis

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1495, Issue 3, 2000, Pages 231-236

  Horiguchi, Hyogo ^a,b   Franklin Bunn, H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Department of Public Health   (Japan)

Author keywords

Erythropoietin; Heme; Hypoxia; Oxygen sensing

Indexed keywords

COBALT; DEFEROXAMINE MESYLATE; ERYTHROPOIETIN; HEMOPROTEIN; ISONIAZID; MESSENGER RNA; N METHYLPROTOPORPHYRIN; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL VIABILITY; HEME SYNTHESIS; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CELL SURVIVAL; DEFEROXAMINE; ENZYME INHIBITORS; ERYTHROPOIETIN; HEME; HEPTANOATES; HUMANS; ISONIAZID; PROTOPORPHYRINS; TUMOR CELLS, CULTURED;

EID: 0343938889     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(99)00169-X     Document Type: Article

References (21)

1. Bunn H.F., Poyton R.O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76:1996;839-885.
2. Goldberg M.A., Glass G.A., Cunningham J.M., Bunn H.F. The regulated expression of erythropoietin by two human hepatoma cell lines. Proc. Natl. Acad. Sci. USA. 84:1987;7972-7976.
3. Goldberg M.A., Dunning S.P., Bunn H.F. Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science. 242:1988;1412-1415.
4. Ebert P.S., Hess R.A., Frykholm B.C., Tscudy D.P. Succinyl acetone. a potent inhibitor of heme biosynthesis: effect on cell growth, heme content and δ-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem. Biophys. Res. Commun. 88:1979;1382-1390.
5. Tschudy D.P., Hess R.H., Frykholm B.C. Inhibition of δ-aminolevulinic acid dehydrase by 4,6-dioxoheptanoic acid. J. Biol. Chem. 256:1981;9915-9923.
6. Ponka P., Wilczynska A., Schulman H.M. Iron utilization in rabbit reticulocytes: A study using succinylacetone as an inhibitor of heme synthesis. Biochim. Biophys. Acta. 720:1982;96-105.
7. Srinivas V., Zhu X., Salceda S., Nakamura R., Caro J. Hypoxia-inducible factor 1α (HIF-1α) is a non-heme iron protein. J. Biol. Chem. 273:1998;18019-18022.
8. Ho V., Acquaviva A., Duh E., Bunn H.F. Use of a marked erythropoietin gene for investigation of its cis-acting elements. J. Biol. Chem. 270:1995;10084-10090.
9. Shedlofsky S.I., Sinclair P.R., Bonkovsky H.L., Healey J.F., Swim A.T., Robinson J.M. Haem synthesis from exogenous 5-aminolaevulinate in cultured chick-embryo hepatocytes. Biochem. J. 248:1987;229-236.
10. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
11. Ponka P., Neuwirt J. Regulation of iron entry into reticulocytes. I. Feedback inhibitory effect of heme on iron entry into reticulocytes and on heme synthesis. Blood. 33:1969;690-707.
12. Cole S.P., Marks G.S. Ferrochelatase and N-alkylated porphyrins. Mol. Cell. Biochem. 64:1984;127-137.
13. DeMatteis F., Marks G.S. The effect of N-methylprotoporphyrin and succinyl-acetone on the regulation of heme biosynthesis in chicken hepatocytes in culture. FEBS Lett. 159:1984;127-131.
14. Wang G.L., Semenza G.L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood. 82:1993;3610-3615.
15. Sinclair P.R., Granick S. Heme control on the synthesis of delta-aminolevulinic acid synthetase in cultured chick embryo liver cells. Ann. NY Acad. Sci. 244:1975;509-520.
16. Cable E.E., Gildemeister O.S., Pepe J.A., Donohue S.E., Lambrecht R.W., Bonkovsky H.L. Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins. Eur. J. Biochem. 240:1996;112-117.
17. Stadtman E.R., Oliver C.N. Metal-catalyzed oxidation of proteins. J. Biol. Chem. 266:1991;2005-2008.
18. Stadtman E.R. Protein oxidation and aging. Science. 257:1992;1220-1224.
19. Sogawa K., Numayama-Tsuruta K., Ema M., Abe M., Abe H., Fujii-Kuriyama Y. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc. Natl. Acad. Sci. USA. 95:1998;7368-7373.
20. Liu Y., Christou H., Morita T., Laughner E., Semenza G.L., Kourembanas S. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor via the 5′ enhancer. J. Biol. Chem. 273:1998;15257-15262.
21. Huang L.E., Willmore W.G., Gu J., Goldberg M.A., Bunn H.F. Inhibition of HIF-1 activation by carbon monoxide and nitric oxide: Implications for oxygen sensing and signaling. J. Biol. Chem. 274:1999;9038-9044.