Nickel-responsive induction of urease expression in Helicobacter pylori is mediated at the transcriptional level

Infection and Immunity

Volumn 69, Issue 8, 2001, Pages 4891-4897

  Van Vliet, A H M ^a   Kuipers, E J ^a   Waidner, B ^a   Davies, B J ^a   De Vries, N ^a   Penn, C W ^a   Vandenbroucke Grauls, C M J E ^a   Kist, M ^a   Bereswill, S ^a   Kusters, J G ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

NICKEL COMPLEX; UREASE;

ARTICLE; BACTERIAL COLONIZATION; CULTURE MEDIUM; ENZYME ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; HELICOBACTER PYLORI; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA ANALYSIS; STOMACH MUCOSA; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; CULTURE MEDIA; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELICOBACTER PYLORI; NICKEL; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; UREASE;

EID: 0034911961     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.8.4891-4897.2001     Document Type: Article

References (58)

1. Identification of the urease operon in Helicobacter pylori and its control by mRNA decay in response to pH
2. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
3. Synthesis and activity of Helicobacter pylori urease and catalase at low pH
4. Allelic exchange mutagenesis of nixA in Helicobacter pylori results in reduced nickel transport and urease activity
5. Regulation of ferritin-mediated cytoplasmic iron storage by the ferric uptake regulator homolog (Fur) of Helicobacter pylori
6. Cloning and characterization of the fur gene from Helicobacter pylori
7. Identification of virulence genes of Helicobacter pylori by random insertion mutagenesis
8. Bacterial ureases in infectious diseases
9. Transcriptional regulation of the Streptococcus salivarius 57.1 urease operon
10. 2+-dependent interaction of NikR with wild-type and mutant operator sites
11. Expression of Helicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions
12. A novel mechanism of urease regulation in Yersinia enterocolitica
13. Isolation and characterization of the nikR gene encoding a nickel-responsive regulator in Escherichia coli
14. Evaluation of a new selective medium for Campylobacter pylori
15. Purification and characterization of urease from Helicobacter pylori
16. Helicobacter pylori
17. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets
18. Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori
19. Nickel transport systems in microorganisms
20. Opening the iron-box: Transcriptional metalloregulation by the Fur protein
21. Identification of iron-regulated Genes of Helicobacter pylori by a modified Fur titration assay (FURTA-Hp)
22. Construction of isogenic urease-negative mutants of Helicobacter pylori by allelic exchange
23. Helicobacter pylori glutamine synthetase lacks features associated with transcriptional and posttranslational regulation
24. Regulation of the cnr cobalt and nickel resistance determinant of Ralstonia sp. strain CH34
25. The demonstration of nickel in the urease of Helicobacter pylori by atomic absorption spectroscopy
26. Helicobacter pylori ABC transporter: Effect of allelic exchange mutagenesis on urease activity
27. Helicobacter pylori cadA encodes an essential Cd(lI)-Zn(II)-Co(II) resistance factor influencing urease activity
28. Purification and N-terminal analysis of urease from Helicobacter pylori
29. Comparative proteome analysis of Helicobacter pylori
30. Nickel binding and immunological properties of the C-terminal domain of the Helicobacter pylori GroES homologue (HspA)
31. Helicobacter pylori containing only cytoplasmic urease is susceptible to acid
32. Construction and characterization of an Escherichia coli strain genetically engineered for Ni(II) bioaccumulation
33. Review article: Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer
34. Helicobacter pylori urease suppresses bactericidal activity of peroxynitrite via carbon dioxide production
35. Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity
36. Isolation of Helicobacter pylori genes that modulate urease activity
37. Role of Hpn and NixA of Helicobacter pylori in susceptibility and resistance to bismuth and other metal ions
38. Molecular biology of microbial ureases
39. Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment
40. Proteus mirabilis urease: Transcriptional regulation by UreR
41. Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pylori
42. Isolation and biochemical and molecular analyses of a species-specific protein antigen from the gastric pathogen Helicobacter pylori
43. Molecular cloning of Helicobacter pylori DNA: Important differences between mcrBC deletion host strains
44. Acid resistance of Helicobacter pylori depends on the UreI membrane protein and an inner membrane proton barrier
45. Molecular cloning: A laboratory manual, 2nd ed.
46. Expression of the Helicobacter pylori urel gene is required for acidic pH activation of cytoplasmic urease
47. The role of internal urease in acid resistance of Helicobacter pylori
48. Activation of Helicobacter pylori ureA promoter by a hybrid Escherichia coli-H. pylori rpoD gene in E. coli
49. The Helicobacter pylori Urel protein is not involved in urease activity but is essential for bacterial survival in vivo
50. Helicobacter pylori urease activity is toxic to human gastric epithelial cells
51. The autoregulatory HspR repressor protein governs chaperone gene transcription in Helicobacter pylori
52. Biological monitoring of nickel in humans
53. Liquid chromatography-inductively coupled plasma mass spectrometry
54. Regulation of the cnr cobalt and nickel resistance determinant of Ralstonia eutropha (Alcaligenes eutrophus) CH34
55. The complete genome sequence of the gastric pathogen Helicobacter pylori
56. A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach
57. Iron acquisition and virulence in Helicobacter pylori: A major role for FeoB, a high-affinity ferrous iron transporter
58. +-gated urea channel: The link between Helicobacter pylori urease and gastric colonization