Dynamic model of ex vivo granulocytic kinetics to examine the effects of oxygen tension, pH, and interleukin-3

Experimental Hematology

Volumn 28, Issue 9, 2000, Pages 1016-1028

  Hevehan, Diane L ^a   Wenning, Larissa A ^a   Miller, William M ^a   Papoutsakis, E Terry ^a  

^a Northwestern University   (United States)

Author keywords

Granulopoiesis; Interleukin 3; Mathematical model; Oxygen tension; pH

Indexed keywords

INTERLEUKIN 3;

ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; CELL KINETICS; CELL LINEAGE; CELL PH; GRANULOPOIESIS; MATHEMATICAL MODEL; NEUTROPHIL; OXYGEN TENSION; PRECURSOR CELL; PRIORITY JOURNAL;

ANTIGENS, CD11; ANTIGENS, CD15; ANTIGENS, CD34; CELL CULTURE; CELL DIFFERENTIATION; COMPUTER SIMULATION; GRANULOCYTES; HEMATOPOIESIS; HUMAN; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-3; KINETICS; MODELS, CHEMICAL; OXYGEN; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033796781     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(00)00505-1     Document Type: Article

References (59)

1. Terstappen L.W., Safford M., Loken M.R. Flow cytometric analysis of human bone marrow. III. Neutrophil maturation. Leukemia. 4:1990;657.
2. Jandl JH (1996) Blood. Textbook of Hematology. Boston: Little, Brown and Company.
3. Koller M.R., Bender J.G., Miller W.M., Papoutsakis E.T. Reduced oxygen tension increases hematopoiesis in long-term culture of human stem and progenitor cells from cord blood and bone marrow. Exp Hematol. 20:1992;264.
4. Koller M.R., Bender J.G., Papoutsakis E.T., Miller W.M. Effects of synergistic cytokine combinations, low oxygen, and irradiated stroma on the expansion of human cord blood progenitors. Blood. 80:1992;403.
5. LaIuppa J.A., Papoutsakis E.T., Miller W.M. Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages. Exp Hematol. 26:1998;835.
6. McAdams T.A., Miller W.M., Papoutsakis E.T. Variations in culture pH affect the cloning efficiency and differentiation of progenitor cells in ex vivo haemopoiesis. Br J Haematol. 97:1997;889.
7. McAdams T.A., Miller W.M., Papoutsakis E.T. pH is a potent modulator of erythroid differentiation. Br J Haematol. 103:1998;317.
8. Hevehan D.L., Papoutsakis E.T., Miller W.M. Physiologically significant effects of pH and oxygen tension on granulopoiesis. Exp Hematol. 28:2000;267.
9. Iscove N.N., Shaw A.R., Keller G. Net increase of pluripotential hematopoietic precursors in suspension culture in response to IL-1 and IL-3. J Immunol. 142:1989;2332.
10. Metcalf D. Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies. influence of colony-stimulating factors Proc Natl Acad Sci U S A. 88:1991;11310.
11. Kelvin D.J., Chance S., Shreeve M., Axelrad A.A., Connolly J.A., McLeod D. Interleukin 3 and cell cycle progression. J Cell Physiol. 127:1986;403.
12. Brandt J.E., Bhalla K., Hoffman R. Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells. Blood. 83:1994;1507.
13. Clark S.C., Kamen R. The human hematopoietic colony-stimulating factors. Science. 236:1987;1229.
14. Loeffler M., Wichmann H.E. Structure of the model. Loeffler M., Wichmann H.E. Mathematical modeling of cell proliferation. stem cell regulation in hemopoiesis:1985;CRC Press, Boca Raton. 55p.
15. Schmitz S., Franke H., Brusis J., Wichmann H.E. Quantification of the cell kinetic effects of G-CSF using a model of human granulopoiesis. Exp Hematol. 21:1993;755.
16. Nielsen LK, Papoutsakis ET, Miller WM (1998) Modelling ex vivo hematopoiesis using chemical engineering metaphors. Chem Eng Sci 53:1913.
17. + cells in autologous stem cell transplantation for breast cancer. Blood. 87:1996;1687.
18. Brugger W., Heimfeld S., Berenson R.J., Mertelsmann R., Kanz L. Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex vivo. N Engl J Med. 333:1995;283.
19. Reiffers J., Calliot C., Dazey B., Attal M., Caraux J., Boiron J.M. Abrogation of post-myeloablative chemotherapy neutropenia by ex-vivo expanded autologous CD34-positive cells. Lancet. 354:1999;1092.
20. Nielsen L.K., Bender J.G., Miller W.M., Papoutsakis E.T. Population balance model of in vivo neutrophil formation following bone marrow rescue therapy. Cytotechnology. 28:1998;157.
21. Scheding S., Franke H., Diehl V.et al. How many myeloid post-progenitor cells have to be transplanted to completely abrogate neutropenia after peripheral blood progenitor cell transplantation? Results of a computer simulation. Exp Hematol. 27:1999;956.
22. Cronkite E.P., Vincent P.C. Granulocytopoiesis. Ser Haemat. 4:1969;3.
23. Mayani H., Lansdorp P.M. Proliferation of individual hematopoietic progenitors purified from umbilical cord blood. Exp Hematol. 23:1995;1453.
24. Schiesser WE (1994) Computational mathematics in engineering and applied science: ODEs, DAEs, and PFEs. Boca Raton: CRC Press.
25. Civin C.I., Loken M.R. Cell surface antigens on human marrow cells. dissection of hematopoietic development using monoclonal antibodies and multiparameter flow cytometry Int J Cell Cloning. 5:1987;267.
26. +11 human umbilical cord blood hematopoietic progenitors with high proliferative and replating potential. Blood. 81:1993;41.
27. +11 stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum. Exp Hematol. 21:1993;1442.
28. Huang S., Law P., Young D., Ho A.D. Candidate hematopoietic stem cells from fetal tissues, umbilical cord blood vs. adult bone marrow and mobilized peripheral blood. Exp Hematol. 26:1998;1162.
29. + hematopoietic cells from different tissues. Stem Cells. 17:1999;265.
30. Cronkite E.P., Fliedner T.M. Granulocytopoiesis. N Engl J Med. 270:1964;1347.
31. Smeby W., Benestad H.B. Simulation of murine granulopoiesis. Blut. 41:1980;47.
32. Young J.C., DiGiusto D., Backer M.P. In vitro characterization of fetal hematopoietic stem cells. range and kinetics of cell production from individual stem cells Biotech Bioeng. 50:1996;465.
33. + cells. effects of hematopoietic growth factors on production of neutrophilic precursors J Hematother. 6:1997;475.
34. Martinson J.A., Unverzagt K., Schaeffer A.et al. Neutrophil precursor generation. effects of culture conditions J Hematother. 7:1998;463.
35. Maritz J.S., Stanley E.R., Yeo G.F., Metcalf C. A model of haemopoietic cell colony formation. Biometrics. 28:1972;801.
36. Roti J.L., Okada S. A mathematical model of cell cycle of L5178Y. Cell Tissue Kinet. 6:1973;111.
37. Francis G.E., Leaning M.S. Stochastic model of human granulocyte-macrophage progenitor cell proliferation and differentiation. I. Setting up the model. Exp Hematol. 13:1985;92.
38. Koller M.R., Bender J.G., Papoutsakis E.T., Miller W.M. Beneficial effects of reduced oxygen tension and perfusion in long-term hematopoietic cultures. Ann N Y Acad Sci. 665:1992;105.
39. Smith S., Broxmeyer H.E. The influence of oxygen tension on the long-term growth in vitro of haematopoietic progenitor cells from human cord blood. Br J Haematol. 63:1986;29.
40. Ishikawa Y., Ito T. Kinetics of hemopoietic stem cells in a hypoxic culture. Eur J Haematol. 40:1988;126.
41. Bradley T.R. The effect of oxygen tension on hematopoietic and fibroblastic cell proliferation in vitro. J Cell Physiol. 97:1978;517.
42. Rich I.N., Kubanek B. The effect of reduced oxygen tension on colony formation of erythropoietic cells in vitro. Br J Haematol. 52:1982;579.
43. Broxmeyer H.E., Cooper S., Gabig T. The effects of oxidizing species derived from molecular oxygen on the proliferation in vitro of human granulocyte-macrophage progenitor cells. Ann N Y Acad Sci. 554:1989;177.
44. Clerch LB, Massaro DJ (1997) Oxygen, gene expression, and cellular function. New York: Marcel Dekker.
45. Avalos B.R. Molecular analysis of the granulocyte colony-stimulating factor receptor. Blood. 88:1996;761.
46. Demetri G.D., Griffin J.D. Granulocyte colony-stimulating-factor and its receptor. Blood. 78:1991;2791.
47. Fliedner T.M., Hoelzer D., Steinbach K.H. Blast cell and granulocyte production in human leukemia. pathophysiological concepts based on computer simulation using discrete modeling techniques Blood Cells. 8:1982;535.
48. Sato N., Sawada K., Koizumi K.et al. In vitro expansion of human peripheral blood CD34+ cells. Blood. 82:1993;3600.
49. + cells Blood. 74:1989;1287.
50. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 81:1993;2844.
51. Migliaccio G., Migliaccio A.R., Druzin M.L., Giardina P.J., Zsebo K.M., Adamson J.W. Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of recombinant human stem cell factor. Blood. 79:1992;2620.
52. 0 and entry into the cell cycle of primitive human hemopoietic progenitors. Proc Natl Acad Sci U S A. 89:1992;4013.
53. + cells. role of G-CSF as survival factor Br J Haematol. 97:1997;146.
54. Itoh Y., Ikebuchi K., Hirashima K. Interleukin-3 and granulocyte colony-stimulating factor as survival factors in murine hemopoietic stem cells in vitro. Int J Hematol. 55:1992;139.
55. Walker F., Nicola N.A., Metcalf D., Burgess A.W. Hierarchical down-modulation of hemopoietic growth factor receptors. Cell. 43:1985;269.
56. Valtieri M., Tweardy D.J., Caracciolo D.et al. Cytokine-dependent granulocytic differentiation. regulation of proliferative and differentiative responses in a murine progenitor cell line J Immunol. 138:1987;3829.
57. Fukunaga R., Ishizaka-Ikeda E., Nagata S. Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell. 74:1993;1079.
58. Steinman R.A., Tweardy D.J. Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells. Blood. 83:1994;119.
59. Steinman R.A., Iro A. Suppression of G-CSF-mediated Stat signalling by IL-3. Leukemia. 13:1999;54.