DAP12: A key accessory protein for relaying signals by Natural Killer cell receptors

International Journal of Biochemistry and Cell Biology

Volumn 31, Issue 6, 1999, Pages 631-636

  Campbell, Kerry S ^a   Colonna, Marco ^b  

^a FOX CHASE CANCER CENTER   (United States)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

DAP12; ITAM; Natural Killer cell; Protein tyrosine phosphorylation; Signal transduction; Syk; ZAP 70

Indexed keywords

CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; TYROSINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CYTOTOXICITY; DENDRITIC CELL; DISULFIDE BOND; HUMAN; HUMAN CELL; MONOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; KILLER CELLS, NATURAL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN CONFORMATION; RECEPTORS, IMMUNOLOGIC; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 0033063287     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(99)00022-9     Document Type: Article

References (17)

1. Leibson P.J. Signal transduction during natural killer cell activation: inside the mind of a killer. Immunity. 6:1997;655-661.
2. Melero I., Salmerón A., Balboa M.A., Aramburu J., López-Botet M. Tyrosine kinase-dependent activation of human NK cell functions upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subsets of NK cells and T lymphocytes. J. Immunol. 152:1994;1662-1673.
3. Moretta A., Sivori S., Vitale M., Pende D., Morelli L., Augugliaro R., Bottino C., Moretta L. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J. Exp. Med. 182:1995;875-884.
4. Bottino C., Sivori S., Vitale M., Cantoni C., Falco M., Pende D., Morelli L., Augugliaro R., Semenzato G., Biassoni R., Moretta L., Moretta A. A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation. Eur. J. Immunol. 26:1996;1816-1824.
5. Brumbaugh K.M., Pérez-Villar J.J., Dick C.J., Schoon R.A., López-Botet M., Leibson P.J. Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses. J. Immunol. 157:1996;2804-2812.
6. Campbell K.S., Cella M., Carretero M., López-Botet M., Colonna M. Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex. Eur. J. Immunol. 28:1998;599-609.
7. McVicar D.W., Taylor L.S., Gosselin P., Willette-Brown J., Mikhael A.I., Geahlen R.L., Nakamura M.C., Linnemeyer P., Seaman W.E., Anderson S.K., Ortaldo J.R., Mason L.H. DAP12-mediated signal transduction in natural killer cells: a dominant role for the Syk protein tyrosine kinase. J. Biol. Chem. 273:1998;32934-32942.
8. Olcese L., Cambiaggi A., Semenzato G., Bottino C., Moretta A., Vivier E. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells. J. Immunol. 158:1997;5083-5086.
9. Mason L.H., Willette-Brown J., Anderson S.K., Gosselin P., Shores E.W., Love P.E., Ortaldo J.R., McVicar D.W. Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction. J. Immunol. 160:1998;4148-4152.
10. Lanier L.L., Corliss B.C., Wu J., Leong C., Phillips J.H. Immunoreceptor DAP12 bearing a tyrosine activation motif is involved in activating NK cells. Nature. 391:1998;703-707.
11. Tomasello E., Olcese L., Vély F., Geourgeon C., Bléry M., Moqrich A., Gautheret D., Djabali M., Mattei M.G., Vivier E. Gene structure, expression pattern and biological activity of mouse KAR-associated protein (KARAP)/DAP-12. J. Biol. Chem. 273:1998;34115-34119.
12. Lanier L.L., Corliss B., Wu J., Phillips J.H. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity. 8:1998;693-701.
13. Smith K.M., Wu J., Bakker A.B.H., Phillips J.H., Lanier L.L. Cutting Edge: Ly-49D and Ly-49H assocaite with mouse DAP12 and form activating receptors. J. Immunol. 161:1998;7-10.
14. Mandelboim O., Kent S., Davis D.M., Wilson S.B., Okazaki T., Jackson R., Hafler D., Strominger J.L. Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells. Proc. Natl. Acad. Sci. USA. 95:1998;3798-3803.
15. Winter C.C., Gumperz J.E., Parham P., Long E.O., Wagtmann N. Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J. Immunol. 161:1998;571-577.
16. Colonna M. Unmasking the killer's accomplice. Nature. 391:1998;642-643.
17. Vitale M., Bottino C., Sivori S., Sanseverino L., Castriconi R., Marcenaro E., Augugliaro R., Moretta L., Moretta A. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187:1998;2065-2072.