Iron overload, oxidative stress, and axonal dystrophy in brain disorders

Pediatric Neurology

Volumn 25, Issue 2, 2001, Pages 138-147

  Chiueh, Chuang C ^a,b,c,d,e  

^a Unit On Neurodegeneration and Neuroprotection   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NIMH ^*

^e NIH 10 3D 41   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; ANTIOXIDANT; DEFEROXAMINE; DOPAMINE; IRON; MANGANESE; TROLOX C;

ASTROCYTE; BASAL GANGLION; BLOOD BRAIN BARRIER; BRAIN DISEASE; CONFERENCE PAPER; DOPAMINERGIC NERVE CELL; GLOBUS PALLIDUS; HALLERVORDEN SPATZ DISEASE; HOMEOSTASIS; HUMAN; IRON METABOLISM; IRON OVERLOAD; IRON TRANSPORT; LIPID BRAIN LEVEL; LIPID PEROXIDATION; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

ANIMALS; BRAIN; CHILD; HALLERVORDEN-SPATZ SYNDROME; HUMANS; IRON; IRON OVERLOAD; MICE; NEUROAXONAL DYSTROPHIES; OXIDATIVE STRESS;

EID: 0034851578     PISSN: 08878994     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-8994(01)00266-1     Document Type: Conference Paper

References (80)

1. Hallervorden-Spatz disease
2. Homozygosity mapping of Hallervorden-Spatz syndrome to chromosome 20p12.3-p13
3. Hallervorden-Spatz syndrome and brain iron metabolism
4. Clinicopathological study of familial late infantile Hallervorden-Spatz disease; A particular form of neuroacanthocytosis
5. Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for α-synuclein
6. Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and Lewy body pathology
7. Early clinical and imaging (high-field MRI) diagnosis of Hallervorden-Spatz disease
8. Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism
9. Hydroxyl radicals, iron, oxidative stress, and neurodegeneration
10. Manganese; A transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonism
11. Hemoglobin and iron-evoked oxidative stress in the brain; Protection by bile pigments, manganese and S-nitrosoglutathione
12. Apparent role of hydroxyl radicals in oxidative brain injury induced by sodium nitroprusside
13. Neuroprotective strategies in Parkinson's disease; Protection against progressive nigral injury induced by free radicals
14. Abnormal iron deposition associated with lipid peroxidation in transgenic mice expressing interleukin-6 in the brain
15. Iron regulation in the brain; Histochemical, biochemical, and molecular considerations
16. Iron-independent neuronal expression of transferrin receptor mRNA in the rat
17. New perspectives on iron; An introduction
18. Transferrin receptor is necessary for development of erythrocytes and the nervous system
19. Cellular distribution of ferric iron, ferritin, transferrin and divalent metal transporter 1 (DMT1) in substantia nigra and basal ganglia of normal and β2-microglobulin deficient mouse brain
20. The ferritins; Molecular properties, iron storage function and cellular regulation
21. Elevated ferritin production, iron containment, and oxidant resistance in hemin-treated leukemia cells
22. Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress
23. Aspirin increases ferritin synthesis in endothelial cells; A novel antioxidant pathway
24. An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding protein
25. Iron species in iron homeostasis and toxicity
26. Regulation and developmental expression of the divalent metal-ion transporter in the rat brain
27. Implications for atypical antioxidative properties of manganese in iron-induced brain lipid peroxidation and copper-dependent low density lipoprotein conjugation
28. Lead potentiates iron-induced formation of reactive oxygen species
29. Ferrous-citrate complex and nigral degeneration; Evidence for free-radical formation and lipid peroxidation
30. S-nitrosothiols and nitric oxide, but not sodium nitroprusside, protect nigrostriatal dopamine neurons against iron-induced oxidative stress in vivo
31. Neuroprotection by nitric oxide against hydroxyl radical-induced nigral neurotoxicity
32. Effects of atypical antioxidative agents, S-nitrosoglutathione and manganese, on brain lipid peroxidation induced by iron leaking from tissue disruption
33. Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury
34. Synaptosomal iron-dependent lipid peroxidation inhibition after subarachnoid hemorrhage by lazaroid in vivo treatment
35. Neuroprotective properties of nitric oxide
36. The redox pathway of S-nitrosoglutathione, glutathione and nitric oxide in cell to neuron communications
37. Neuroprotection by S-nitrosoglutathione of brain dopamine neurons from oxidative stress
38. shc by human NOS1 enhances tolerance to oxidative stress
39. +)-induced neurotoxicity
40. GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide
41. Regulation of heme oxygenase-1 expression by dopamine in cultured C6 glioma and primary astrocytes
42. Intraneuronal aluminum potentiates iron-induced oxidative stress in cultured rat hippocampal neurons
43. The stabilization of ferrous iron by a toxic β-amyloid fragment and by an aluminum salt
44. Kynostatin and 17β-estradiol prevent the apoptotic death of human neuroblastoma cells exposed to HIV-1 protease
45. Iron-induced apoptosis in the photoreceptor cells of rats
46. Iron-induced cytotoxicity in cultured rat retinal neurons
47. A case of hereditary ceruloplasmin deficiency with iron deposition in the brain associated with chorea, dementia, diabetes mellitus and retinal pigmentation; Administration of fresh-frozen human plasma
48. Recurrent seizures induced by cortical iron injection; A model of posttraumatic epilepsy
49. Effects of intracortical injection of blood and blood components on the electrocorticogram
50. The role of iron-induced hippocampal peroxidation in acute epileptogenesis
51. Reduction in nitric oxide synthase activity with development of an epileptogenic focus induced by ferric chloride in the rat brain
52. Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures
53. Radical trapping and inhibition of iron-dependent CNS damage by cyclic nitrone spin traps
54. Melatonin inhibits iron-induced epileptic discharges in rats by suppressing peroxidation
55. Transferrin and transferrin receptor function in brain barrier systems
56. Hydroxyl free radical (·OH) formation reflected by salicylate hydroxylation and neuromelanin. In vivo markers for oxidant injury of nigral neurons
57. Cytokines in neurodegeneration and repair
58. Novel protective effect of manganese against ferrous citrate-induced lipid peroxidation and nigrostriatal neurodegeneration in vivo
59. Acidosis potentiates oxidative neuronal death by multiple mechanisms
60. The toxic effects of desferrioxamine
61. Toxic effects of high-dose deferoxamine treatment in patients with iron overload; An electrophysiological study of cerebral and visual function
62. Nitroxide SOD-mimics. modes of action
63. A potent superoxide dismutase mimic; Manganese β-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin
64. Manganese dipyridoxyl diphosphate; MRI contrast agent with antioxidative and cardioprotective properties?
65. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats
66. Manganese superoxide dismutase overexpression attenuates MPTP toxicity
67. The use of transgenic and mutant mice to study oxygen free radical metabolism
68. Temporal profile of heat shock protein 70 synthesis in ischemic tolerance induced by preconditioning ischemia in rat hippocampus
69. Effects of hypoxia preconditioning on expression of metallothionein-1,2 and heme oxygenase-1 before and after kainic acid-induced seizures
70. The effect of melatonin on lipid peroxidation during radiotherapy in female rats
71. Melatonin suppresses iron-induced neurodegeneration in rat brain
72. Assessing the effects of deprenyl on longevity and antioxidant defenses in different animal models
73. Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments
74. + dopaminergic toxicity
75. Estrogen use and early onset Alzheimer's disease; A population-based study
76. Vascular nitric oxide, sex hormone replacement, and fish oil may help to prevent Alzheimer's disease by suppressing synthesis of acute-phase cytokines
77. Estrogen to treat Alzheimer's disease; Too little, too late? So what's a woman to do?
78. Estradiol protects against injury-induced cell death in cortical explant cultures; A role for estrogen receptors
79. The late phase of preconditioning
80. Dopamine in the extrapyramidal motor function. A study based upon the MPTP-induced primate model of parkinsonism