Synaptosomal iron-dependent lipid peroxidation inhibition after subarachnoid hemorrhage by lazaroid in vivo treatment

Molecular and Chemical Neuropathology

Volumn 30, Issue 1-2, 1997, Pages 15-24

  Torri, Carla ^a   Café, Carla ^a   Adinolfi, Daniela ^b   Gaetani, Paolo ^b   Rodriguez Y Baena, Riccardo ^b   Marzatico, Fulvio ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

21 aminosteroid; antioxidant; free radicals; hydroxyl radical; lazaroid; lipid peroxidation; oxygen radicals; Subarachnoid hemorrhage; TBARs

Indexed keywords

2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; 21 AMINOSTEROID; ANTIOXIDANT; HYDROXYL RADICAL; LAZAROID; OXYGEN RADICAL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CISTERNA MAGNA; CONTROLLED STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; PEROXIDATION; PRIORITY JOURNAL; RAT; STRESS; SUBARACHNOID HEMORRHAGE; SYNAPTIC MEMBRANE; SYNAPTOSOME;

ANIMALIA;

EID: 0031042195     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02815147     Document Type: Article

References (43)

1. Abe K., Yoshidomi M., and Kogure K. (1989) Arachidonic acid metabolism in ischemic neuronal damage. Ann. NY Acad. Sci. 559, 259-268.
2. Althaus J. S., Williams C. W., Andrus P. K., Yonkers P. A., Fici G. J., Hall E. D., and Von Voigtlander P. F. (1991) In vitro and in vivo analysis of tirilazad mesylate (U74006F) as a hydroxyl radical scavenger. Soc. Neurosci. Abstract 17, 164-175.
3. Asano T., Matsui T., and Takuwa Y. (1991) Lipid peroxidation, protein kinase C and cerebral vasospasm. Crit. Rev. Neurosurg. 1, 361-379.
4. Audus K. L., Guillot F. L., and Braughler J. M. (1991) Evidence for 21-aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells. Free Radical Biol. Med. 11, 361-371.
5. Braughler J. M. and Hall E. D. (1989) Central nervous system trauma and stroke: I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Radical Biol. Med. 6, 289-301.
6. Braughler J. M. and Pregenzer J. F. (1989) The 21-aminosteroid inhibitors of lipid peroxidation: Reactions with lipid peroxil and phenoxyl radicals. Free Radical Biol. Med. 7, 125-130.
7. Braughler J. M., Pregenzer J. F., Chase R. L., Duncan L. A., Jacobsen E. J., and McCall J. M., (1987) Novel 21-amino steriods as potent inhibitors of iron-dependent lipid peroxidation. J. Biol. Chem. 262, 10438-10440.
8. Braughler J. M., Hall E. D., Jacobsen E. J., McCall J. M., and Means E. D. (1989) The 21-aminosteroids: potent inhibitors of lipid peroxidation for the treatment of central nervous system trauma and ischemia. Drugs Future 14, 143-152.
9. Chan P. H. and Fishman R. A. (1980) Transient formation of superoxide radicals in polyunsaturated fatty acid induced brain swelling. J. Neurochem. 35, 1004-1007.
10. Cohen G. (1988) Oxygen radicals and Parkinson's disease, in Oxygen Radicals and Tissue Injury (Halliwell B., ed.) FASEB, Bethesda, MD, pp. 130-135.
11. + gradients, and neurotransmitter amino acid levels in isolated rat brain synaptosomes. J. Neurochem. 49, 1229-1240.
12. Delgado T. J., Brismar J., and Svengaard N. A. (1985) Subarachnoid hemorrhage in the rat: Angiography and fluorescence microscopy of the major arteries. Stroke 16, 595-602.
13. Fiske C. H. and Subbarow Y. (1925) The colorimetric deterimination of phosphorus. J. Biol. Chem. 66, 375-400.
14. Gaetani P., Marzatico F., Lombardi D., Adinolfi D., and Rodriguez y Baena R. (1991) Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats. Stroke 22, 215-220.
15. Grotta J. C., Pettigrew L. C., Lockwood A. H., and Reich C. (1987) Brain extraction of a calcium channel blocker. Ann. Neurol. 21, 171-175.
16. Hall E. D. and Braughler J. M. (1993) Free radicals in CNS injury, in Molecular and Cellular Approaches to the Treatment of Neurological Disease (Waxman, S. G., ed.) Raven, New York, pp. 81-105.
17. Hall E. D., Pazara K. E., and Braughler J. M. (1988) The 21-aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke 19, 997-1002.
18. Hall E. D., Pazara K. E., Braughler J. M., Linseman K. L., and Jacobsen E. J. (1990) Nonsteroidal lazaroid U78517F in models of focal and global ischemia. Stroke 21 (Suppl. III), 83-87.
19. Halliwell B. (1978) Biochemical mechanisms accounding for the action of oxygen of living organisms: the key role of superoxide dismutase. Cell Biol. Int. Rep. 2, 113-128.
20. Halliwell B. and Gutteridge J. M. C. (1985) Oxygen radicals and nervous system. Trends Neurosci. 8, 22-26.
21. Halliwell B. and Gutteridge J. M. C. (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 186, 1-85.
22. Harris M. E., Hensley K., Butterfield D. A., Leedle R. A., and Carney J. M. (1995) Direct evidence of oxidative injury produced by the Alzheimer's β-amyloid peptide (1-40) in cultered hippocampal neurons. Exp. Neurol. 131, 193-202.
23. Huschmann O. R. and Nathanson D. C. (1985) The role of calcium and cellular membrane dysfunction in experimental trauma and subarachnoid hemorrhage. J. Neurosurg. 62, 698-703.
24. Jackowski A., Crockard H. A., Ross Russell R. W., and Burnstock G. (1989) SAH in a rat model: the time course of change in cerebral blood flow, cerebral perfusion, and intracranial pressure. J. Cereb. Blood Flow Metab. 9 (Suppl. 1), S455.
25. Kanamaru K., Weir B. K. A., Simpson I., Witbeck T., and Grace M. (1991) Effect of 21-aminosteroid U-74006F on lipid peroxidation in subarachnoid clot. J. Neurosurg. 74, 454-459.
26. Kontos H. A. and Povlishock J. T. (1986) Oxygen radicals in brain injury. CNS Trauma 3, 257-263.
27. LeBel C. P. and Bondy S. C. (1991) Oxygen radicals: common mediators of neurotoxicity. Neurotoxicol. Teratol. 13, 341-346.
28. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
29. Marzatico P., Gaetani P., Rodriguez y Baena R., Silvani V., Paoletti P., and Benzi G. (1988) Bioenergetics of different brain areas after experimental subarachnoid hemorrhage in rats. Stroke 19, 378-384.
30. +-ATPase in different rat brain areas. Mol. Chem. Neuropathol. 11, 99-107.
31. Marzatico F., Gaetani P., Silvani V., Lombardi D., Sinforiani E., and Rodriguez y Baena R. (1990) Experimental isobaric subarachnoid hemorrhage: regional mitochondrial function during the acute and late phase. Surg. Neurol. 34, 294-300.
32. McIntosh T., Banbury M., and Smith D. (1991) The novel 21-aminosteroid U74006F attentuates cerebral oedema and improves survival after brain injury in the rat. Acta Neurochir. 51 (Suppl.), 329-330.
33. Ohkawa H., Ohishi N., and Yagi K. (1951) Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358.
34. Sano K., Asano T., Tanishima T., and Sasaki T. (1980) Lipid peroxidation as a cause of cerebral vasospasm. Neurol. Res. 2, 253-272.
35. Siesjo B. K. (1981) Cell damage in the brain: a speculative synthesis. J. Cereb. Blood Flow Metab. 1, 155-185.
36. Siesjo B. K., Agardh C. D., and Bengtsson F. (1989) Free radicals and brain damage. Cerebrovasc. Brain Metab. Rev. 1, 165-211.
37. Solomon R. A., Lobo Antunes J., Chen R. Y. Z., Bland L., and Chien S. (1985) Decrease in cerebral blood flow in rats after experimental subarachnoid hemorrhage: A new model. Stroke 16, 58-64.
38. Tappel A. L. (1974) Lipid peroxidation damage to cell components. Fed. Proc. 32, 1870-1874.
39. Traystman R. J., Kirsch J. R., and Koehler R. C. (1991) Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71, 1185-1195.
40. Volby B., Enevoldsen E. M., and Jensen F. T. (1985) Regional CBF, intraventricular pressure and cerebral metabolism in patients with rupture intracranial aneurysms. Biochem. J. 146, 713-722.
41. Watson B. D. and Ginsberg M. D. (1989) Ischemi injury in the brain. Role of oxygen radical-mediated processes. Ann. NY Acad. Sci. 559, 269-281.
42. Youdim M. B. H. and Ben-Schachar D. (1990) The neurotoxic component in Parkinson's disease may involve iron-melanin interaction and lipid peroxidation in the substantia nigra. N. Vistas Drug Res. 1, 111-122.
43. Zuccarello M., Marsch J. T., Schmitt G., Woodward J., and Anderson D. K. (1989) Effect of the 21-aminosteroid U-74006F on cerebral vasospasm following subarachnoid hemorrhage. J. Neurosurg. 71, 98-104.