Reduction in nitric oxide synthase activity with development of an epileptogenic focus induced by ferric chloride in the rat brain

Epilepsy Research

Volumn 25, Issue 2, 1996, Pages 65-68

  Kabuto, Hideaki ^a   Yokoi, Isao ^a   Habu, Hitoshi ^a   Willmore, L James ^b   Mori, Akitane ^a   Ogawa, Norio ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Epileptic focus; Iron induced seizures; Nitric oxide synthase

Indexed keywords

FERRIC CHLORIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPSY; EPILEPTOGENESIS; INTRACEREBRAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030271573     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-1211(96)00063-0     Document Type: Article

References (25)

1. [1] Avoli, M. and Olivier, A., Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist, Neurosci. Lett., 76 (1987) 249-254.
2. [2] Bredt, D.S. and Snyder, S.H., Nitric oxide mediates glutamate linked enhancement of cGMP levels in the cerebellum, Proc. Natl. Acad. Sci. USA, 86 (1989) 9030-9033.
3. [3] Buisson, A., Lakhmeche, N., Verrecchia, C., Plotkine, M. and Boulu, R.G., Nitric oxide: an endogenous anticonvulsant substance, NeuroReport, 4 (1993) 444-446.
4. [4] Church, J., Davies, S.N. and Lodge, D., A correlation between N-methylaspartate antagonist and anticonvulsant properties of PCP/sigma receptor agonists, Br. J. Pharmacol., 87 (1986) 270.
5. [5] Croucher, M.J., Collins, J.F. and Meldrum, B.S., Anticonvulsant action of excitatory amino acid antagonists, Science, 216 (1982) 899-901.
6. [6] Garthwaite, J., Garthwaite, G., Palmer, R.M.J. and Moncada, S., NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices, Eur. J. Pharmacol., 172 (1989) 413-416.
7. 15N]nitrate in biological fluids, Anal. Biochem., 126 (1982) 131-138.
8. [8] Hablitz, J.J. and Langmoen, I.A., N-Methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampus, J. Neurosci., 6 (1986) 102-106.
9. [9] Habu, H., Yokoi, I., Kabuto, H. and Mori, A., Application of automated flow injection analysis to determine nitrite and nitrate in mouse brain, NeuroReport, 5 (1994) 1571-1573.
10. [10] Hiramatsu, M., Fukushima, M., Kabuto, H., Edamatsu, R. and Mori, A., Amino acids, 5-hydroxytryptamine, and catecholamines in iron-induced epileptogenic foci of the rat, Adv. Epileptol., 16 (1987) 151-154.
11. [11] Janjua, N.A., Mori, A. and Hiramatsu, M., Increased aspartic acid release from the iron-induced epileptogenic focus, Epilepsy Res., 6 (1990) 215-220.
12. [12] Jennet, B., Epilepsy and acute traumatic intracranial hematoma, J. Neurol. Neurosurg. Psychiat., 38 (1975) 378-381.
13. [13] Lehmann, J., Schneider, J., McPherson, S., Murphy, D.E., Bernard, P., Tsai, C., Bennett, D.A., Pastor, G., Steel, D.J., Boehm, C., Cheney, D.L., Liebman, J.M., Williams, M. and Wood, P.L., CPP, a selective N-methyl-D-aspartate (NMDA) type receptor antagonist: characterization in vitro and in vivo, J. Pharmacol. Exp. Ther., 240 (1987) 737-746.
14. [14] Lowry, O.J., Rosebrough, N.J., Farr, A.L. and Randall, R.L., Protein measurement with folin-phenol reagent, J. Biol. Chem., 193 (1951) 265-275.
15. [15] Mori, A., Hiramatsu, M. and Yokoi, I., Posttraumatic epilepsy, free radicals and antioxidant therapy. In: L. Packer, L. Prilipko and Y. Christen (Eds.), Free Radicals in the Brain, Aging, Neurological and Mental Disorders, Springer, Berlin, 1992, pp. 109-122.
16. [16] Payan, H., Taga, M. and Berard-Badier, M., The pathology of posttraumatic epilepsies, Epilepsia, 11 (1970) 80-90.
17. 3-induced epileptogenic foci in cat; electrophysiological analysis, Brain Res., 188 (1980) 531-541.
18. [18] Rondouin, G., Lerner-Natoli, M., Manzoni, O., Lafon-Cazal, M. and Bockaert, J., A nitric oxide (NO) synthase inhibitor accelerates amygdala kindling, NeuroReport, 3 (1992) 805-808.
19. [19] Schuman, E.M. and Madison, D.V., A requirement for the intercellular messenger nitric oxide in long-term potentiation, Science, 254 (1991) 1503-1506.
20. [20] Shibuki, K. and Okada, D., Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum, Nature, 349 (1991) 326-328.
21. 3 injection into rat isocortex, Brain Res., 277 (1983) 393-396.
22. [22] Willmore, L.J., Hurd, R.W. and Sypert, G.W., Epileptiform activity initiated by pial iontophoresis on ferrous and ferric chloride on rat cerebral cortex, Brain Res., 152 (1978) 406-410.
23. [23] Willmore, L.J., Hurd, R.W., Sypert, G.W. and Hurd, R.W., Chronic focal epileptiform discharges induced by injection of iron ions into rat and cat cortex, Science, 200 (1978) 1501-1503.
24. [24] Willmore, L.J. and Rubin, J.J., Antiperoxidant pretreatment and iron-induced epileptiform discharges in the rat: EEG and histopathologic studies, Neurology, 31 (1981) 63-69.
25. [25] Willmore, L.J., Sypert, G.W. and Munson, J.B., Recurrent seizures induced by cortical iron injection: a model of posttraumatic epilepsy, Ann. Neurol., 4 (1978) 329-336.