Radical trapping and inhibition of iron-dependent CNS damage by cyclic nitrone spin traps

Journal of Neurochemistry

Volumn 68, Issue 3, 1997, Pages 1173-1182

  Thomas, Craig E ^a,b   Ohlweiler, David F ^a   Taylor, Vicki L ^a   Schmidt, Christopher J ^a  

^a SANOFI   (France)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Cyclic nitrones; Iron; Neurodegeneration; Radicals; Spin traps

Indexed keywords

3,4 DIHYDRO 3,3 DIMETHYLISOQUINOLINE 2 OXIDE; ANTIOXIDANT; CYCLIC NITRONE; FERROUS ION; MDL 102832; MDL 74722; N TERT BUTYL ALPHA PHENYLNITRONE; NEUROPROTECTIVE AGENT; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; GRANULE CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; MORTALITY; NERVE DEGENERATION; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALIA;

EID: 0031017892     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68031173.x     Document Type: Article

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