Endothelial dysfunction and type 2 diabetes. Part 2: Altered endothelial function and the effects of treatments in type 2 diabetes mellitus

Diabetes and Metabolism

Volumn 27, Issue 4 I, 2001, Pages 436-447

  Guerci, B ^a   Bohme P ^a   Kearney Schwartz, A ^a   Zannad, F ^a   Drouin, P ^a  

^a Ctr Hospitalier Univ de Nancy   (France)

Author keywords

Diabetic angiopathy; Endothelial function; Endothelium; Hyperglycemia; Hyperlipidemia; Insulin; Insulin resistance; Oxidant stress; Type 2 diabetes mellitus

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; ATORVASTATIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLICLAZIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; METFORMIN; ORAL ANTIDIABETIC AGENT; QUINAPRIL; SIMVASTATIN;

ARTERY DIAMETER; BLOOD GLUCOSE MONITORING; CARDIOVASCULAR RISK; CLINICAL TRIAL; CORONARY ARTERY; DIABETIC ANGIOPATHY; DIET THERAPY; DYSLIPIDEMIA; HORMONE SUBSTITUTION; HUMAN; HYPERGLYCEMIA; HYPERTENSION; INSULIN RESISTANCE; INSULIN TREATMENT; KINESIOTHERAPY; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; REVIEW; THROMBOSIS; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIABETIC DIET; ENDOTHELIUM, VASCULAR; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; OXIDATIVE STRESS;

EID: 0034847929     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (99)

1. Vasomotor changes in isolated coronary arteries from diabetic rats
2. Coronary artery responses to physiological stimuli are improved by deferoxamine but not by L-Arginine in non-insulin-dependent diabetic patients with angiographically normal coronary arteries and no other risk factors
3. In vivo endothelial dysfunction characterizes patients with impaired fasting glucose
4. Close relationship of abnormal glucose tolerance with endothelial dysfunction in hypertension
5. Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients
6. Specific impairment of endothelium-dependent vasodilation in subjects with type 2 diabetes
7. Type 2 diabetes abrogates sex differences in endothelial function in premenopausal women
8. Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus
9. Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria
10. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus
11. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
12. Human coronary microvessels in diabetes and ischaemia: Morphometric study of autopsy material
13. Preserved endothelial function in IDDM patients, but not in NIDDM patients, compared with healthy subjects
14. Inhibition and stimulation of nitric oxide synthesis the human forearm arterial bed of patients with insulin-dependent diabetes
15. Acute hyperglycemia depresses arteriolar no formation in skeletal muscle
16. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery
17. Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: An effect prevented by vitamins C and E
18. Endothelium-dependent flow-mediated vasodilation in the postprandial state in type 2 diabetes mellitus
19. Acute hyperglycemia attenuates endothelum-dependent vasodilation in humans in vivo
20. Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C
21. Induction of endothelin-1 expression by glucose. An effect of protein kinase C activation
22. Factors regulating the expression of vascular permeability/vascular endothelial growth factor by human vascular tissues
23. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes
24. Elevated concentrations of soluble E-selectin and vascular cell adhesion molecule-1 in NIDDM
25. Free radicals in diabetic endothelial cell dysfunction
26. Free radicals mediate endothelial cell dysfunction caused by elevated glucose
27. Endothelial cell dysfunction and the pathogenesis of diabetic macroangiopathy
28. Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment
29. Glycation, oxidative stress, and scavenger activity. Glucose metabolism and radical scavenger dysfunction in endothelial cells
30. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release
31. Hemodynamic actions of insulin
32. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation
33. Obesity/insulin resistance is associated with endothelial dysfunction. Implication for the syndrome of insulin resistance
34. Plasma endothelin-1 in obese hypertensive and normotensive men
35. Relationship between insulin sensitivity and maximal forearm blood flow in young men
36. The coupling of glucose metabolism and perfusion in human skeletal muscle. The potential role of endothelium-derived nitric oxide
37. Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men
38. Kinetics of insulin action in vivo. Identification of rate-limiting steps
39. Endothelial dysfunction: Cause of the insulin resistance syndrome
40. Pharmacological modulation of endothelial function by insulin in the rat aorta
41. Insulin stimulates production and secretion of endothelin from bovine endothelial cells
42. Impaired endothelium-dependent and independent dilatation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes: Role of dyslipidaemia
43. Low-density lipoprotein size, high-density lipoprotein concentration, and endothelial dysfunction in non-insulin-dependent diabetes
44. Impaired endothelium-dependent vasodilation in type 2 diabetes. Relation to LDL size, oxidized LDL, and antioxidants
45. Influence of low density lipoprotein (LDL) subfraction profile and LDL oxidation on endothelium-dependent and independent vasodilation in patients with type 2 diabetes
46. Increased ability of LDL from normolipidemic type 2 diabetic women to generate peroxides
47. Regulation of G-protein alpha 12 subunit expression by oxidized low-density lipoprotein
48. Inactivation of endothelial derived relaxing factor by oxidized lipoproteins
49. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase
50. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins
51. Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation
52. Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
53. Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein
54. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium
55. Oxidized lipoproteins found in patients with NIDDM stimulate radical-induced monocyte chemoattractant protein-1 mRNA expression in cultured human endothelial cells
56. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis
57. Human cardiac microvascular and macrovascular endothelial cells respond differently to oxidatively modified LDL
58. Preserved endothelial function in patients with severe hypertriglyceridemia and low functional lipoprotein lipase activity
59. Hypertriglyceridemia enhances monocyte binding to endothelial cells in NIDDM
60. Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion
61. Non-specific inhibition by human lipoproteins of endothelium dependent relaxation in rat aorta may be attributed to lipoprotein phospholipids
62. Effects of single high-fat meal on endothelial function in healthy subjects
63. Not acute but chronic hypertriglyceridemia is associated with impaired endothelium-dependent vasodilatation. Reversal after lipid-lowering therapy by atorvastatin
64. Resistance vessel endothelial function in healthy humans during transient postprandial hypertriglyceridemia
65. Remnants of chylomicron and very low density lipoprotein impair endothelium-dependent vasorelaxation
66. Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes
67. The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes
68. Expression of the VLDL receptor in endothelial cells
69. Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C-independent mechanism
70. Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells
71. A novel endothelial-derived lipase that modulates HDL metabolism
72. Microvascular function in type 2 (non-insulin-dependent) diabetes: Improved vasodilation after one year of good glycaemic control
73. Insulin therapy improves endothelial function in type 2 diabetes
74. Dietary supplementation with marine fish oil improves in vitro small artery endothelial function in hypercholesterolemic patients: A double-blind placebo-controlled study
75. Metformin improves vascular function in insulin-resistant rats
76. Metformin improves hemodynamic and theological responses to L-arginine in NIDDM patients
77. Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects
78. Treatment with acarbose may improve endothelial dysfunction in streptozotocin-induced diabetic rats
79. Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone
80. The impairment in endothelial function induced by non-esterified fatty acids can be reversed by insulin
81. Lipids and endothelial function: Effects of lipid-lowering and other therapeutic interventions
82. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease
83. Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering
84. Hydroxy-methylglutaryl-coenzyme a reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance
85. Endothelial dysfunction is not reversed by simvastatin treatment in type 2 diabetic patients with hypercholesterolemia
86. Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus
87. Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in type 2 diabetes mellitus
88. Chronic vitamin E administration improves brachial reactivity and increases intracellular magnesium concentration in type II diabetic patients
89. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal
90. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
91. Oral treatment with an antioxidant (raxofelast) reduces oxidative stress and improves endothelial function in men with type II diabetes
92. Improvement in endothelial function by angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus
93. Effects of perindopril and carvedilol on endothelium-dependent vascular functions in patients with diabetes and hypertension
94. The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women
95. Estrogen improves endothelial function
96. Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis
97. The effect of hormonal replacement therapy on the vascular reactivity and endothelial function of healthy individuals and individuals with type 2 diabetes
98. Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase
99. Effect of exercise on coronary endothelial function in patients with coronary artery disease