Pharmacological modulation of endothelial function by insulin in the rat aorta

Journal of Pharmacy and Pharmacology

Volumn 50, Issue 10, 1998, Pages 1117-1120

  Laight, D W ^a   Kaw, A V ^a   Carrier, M J ^a   Anggard E E ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE DIPHOSPHATE; ANTIDIABETIC AGENT; CALCIMYCIN; HISTAMINE; INSULIN; MUSCARINIC RECEPTOR; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; HYPERINSULINEMIA; MALE; MODULATION; NONHUMAN; RAT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0031737307     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1998.tb03321.x     Document Type: Article

References (29)

1. Bar, R. S., Harrison, L. C., Muggeo, M., Gorden, P., Kahn, C. R., Roth, J. (1979) Regulation of insulin receptors in normal and abnormal physiology in humans. Adv. Intern. Med. 24: 23-52
2. Bar, R. S., Boes, M., Dake, B. L., Booth, B. A., Henley, S. A., Sandra, A. (1988) Insulin, insulin-like growth factors, and vascular endothelium. Am. J. Med. 85: 59-70
3. Baron, A, D. (1994) Haemodynamic actions of insulin. Am. J. Physiol. 267: E186-E202
4. Baron, A. D. (1996) The coupling of glucose metabolism and perfusion in human skeletal muscle. The potential role of endothelium-derived nitric oxide. Diabetes 45: S105-S109
5. Baron, A. D., Brechtel, G. (1993) Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am. J. Physiol. Endocrinol. Metab. 265: E61-E67
6. Chen, Y. L., Messina, E. J. (1996) Dilation of isolated skeletal muscle arterioles by insulin is endothelium dependent and nitric oxide mediated. Am. J. Physiol. 39: H2120-H2124
7. Furchgott, R. F., Zawadzki, J. V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376
8. Graves, J., Poston, L. (1993) β-Adrenoceptor agonist-mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric oxide. Br. J. Pharmacol. 108: 631-637
9. Gros, R., Borkowski, K. R., Feldman, R. D. (1994) Human insulin-mediated enhancement of vascular beta-adrenergic responsiveness. Hypertension 23: 551-555
10. 2+ level and contraction in the rat aorta. Circ. Res. 77: 673-678
11. Haylor, J. H., Singh, I., El Nahas, A. M. (1991) Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor 1. Kidney Int. 39: 333-335
12. Karasu, C., Altan, V. M. (1993) The role of endothelial cells on the alterations in vascular reactivity induced by insulin-dependent diabetes mellitus: effects of insulin treatment. Gen. Pharmacol. 24: 743-755
13. Laakso, M., Edelman, G., Brechtel, G., Brown, A. D. (1992) Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow. Am. J. Physiol. 263: E199-E204
14. Lembo, G., Iaccarino, G., Vecchione, C., Rendina, V., Trimarco, B. (1995) Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats. Hypertension 26: 290-293
15. McNally, P. G., Lawrence, I. G., Watt, P. A. C., Hillier, C., Burden, A. C., Thurston, H. (1995) The effect of insulin on the vascular reactivity of isolated resistance arteries taken from healthy volunteers. Diabetologia 38: 467-473
16. Muggeo, M., Bar, R. S., Roth, J. (1977) Change in affinity of insulin receptors following oral glucose in normal adults. J. Clin. Endocrinol. Metab. 44: 1206-1209
17. Palmer, R. M. J., Ferrige, A. G., Moncada, S. (1987) Nitric oxide accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526
18. Peuler, J. D., Johnson, B. A., Phare, S. M., Sowers, J. R. (1993) Sex-specific effects of an insulin secretagogue in strokeprone hypertensive rats. Hypertension 22: 214-220
19. Scherrer, U., Randin, D., Vollenweider, P., Vollenweider, L., Nicod, P. (1994) Nitric oxide release accounts for insulin's vascular effects in humans. J. Clin. Invest. 94: 2511-2515
20. Standley, P. R., Ram, J. L., Sowers, J. R. (1993) Insulin attenuation of vasopressin-induced calcium responses in arterial smooth muscle from Zucker rats. Endocrinology 133: 1693-1699
21. Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N., Baron, A. D. (1994) Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. J. Clin. Invest. 94: 1172-1179
22. Taddei, S., Salvetti, A. (1997) Insulin and vascular reactivity. Nutr. Metab. Cardiovasc. Dis. 7: 117-123
23. Taddei, S., Virdis, A., Mattei, P., Natali, A., Ferrannini, E., Salvetti, A. (1995) Effect of insulin on acetylcholine-induced vasodilation in normotensive subjects and patients with essential hypertension. Circulation 92: 2911-2918
24. Walker, A. B., Savage, M. W., Dores, J., Williams, G. (1997) Insulin-induced attenuation of noradrenaline-mediated vaso-constriction in resistance arteries from Wistar rats is nitric oxide dependent. Clin. Sci. 92: 147-152
25. Walsh, M. F., Barazi, M., Pete, G., Muniyappa, R., Dunbar, J. C., Sowers, J. R. (1996) Insulin-like growth factor I diminishes in vivo and in vitro vascular contractility-role of vascular nitric oxide. Endocrinology 137: 1798-1803
26. Wan, Y., Kurosaki, T., Huang, X.-Y. (1996) Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors. Nature 380: 541-544
27. White, M. F., Kahn, C. R. (1994) The insulin signalling system. J. Biol. Chem. 269: 1-4
28. Wu, H. Y., Jeng, Y. Y., Yue, C. J., Hsueh, W. A., Chan, T. M. (1994) Endothelial-dependent vascular effects of insulin and insulin-like growth factor I in the perfused rat mesenteric artery and aortic ring. Diabetes 43: 1027-1032
29. Zeng, G., Quon, J. (1996) Insulin-stimulated production of nitric oxide is inhibited by wortmannin. J. Clin. Invest. 98: 894-898