Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: Models for depression and anxiety?

Physiology and Behavior

Volumn 73, Issue 5, 2001, Pages 811-825

  Gass, Peter ^a   Reichardt, Holger M ^b   Strekalova, Tatyana ^a   Henn, Fritz ^a   Tronche, Francois ^b  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Animal models; Anxiety; Depression; Gene targeting; Glucocorticoid receptor; Mineralocorticoid receptor; Transcription factors; Transgenic mice

Indexed keywords

GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; PROTEIN;

ANIMAL MODEL; ANXIETY; BEHAVIOR; CENTRAL NERVOUS SYSTEM; DEPRESSION; DRUG TARGETING; GENE CONTROL; GENE MUTATION; GENE TARGETING; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MENTAL DISEASE; NEUROENDOCRINOLOGY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; STRESS; SYMPTOM; TRANSGENIC MOUSE;

EID: 0034820849     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(01)00518-2     Document Type: Article

References (110)

1. Glucocorticoid feedback resistance
2. Brain corticosteroid receptor balance in health and disease
3. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: Implication for understanding the states of fear and anxiety and allostatic load
4. The role of corticotropin-releasing factor in depression and anxiety disorders
5. Hippocampal remodelling and damage by corticosteroids: Implications for mood disorders
6. Psychological stress and neuroendocrine function in humans: The two last decades of research
7. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
8. The corticosteroid receptor hypothesis of depression
9. Antidepressants and HPA regulation
10. Pituitary-adrenal system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and in normal comparison subjects
11. Cortisol response to the combined dexamethasone CRH test predicts medium-term outcome in patients with remitted depression
12. Dysregulation of the hypothalamic-pituitary-adrenocortical system in panic disorder
13. Hypothalamic-pituitary-adrenal axis activity in panic disorder 24-hour secretion of corticotropin and cortisol
14. Monoamine dysfunction and the pathophysiology and treatment of depression
15. Animal models as simulations of depression
16. Animal models of depression: Utility for transgenic research
17. Measurement of anxiety in transgenic mice
18. Genetic dissection of glucocorticoid receptor function in mice
19. New insights into glucocorticoid and mineralocorticoid signalling: Lessons from gene targeting
20. Regulation of corticosteroid receptor gene expression in depression and antidepressant action
21. Mutagenesis of the glucocorticoid receptor in mice
22. "Cre"-ating mouse mutants - A meeting review on conditional mouse genetics
23. Primary structure and expression of a functional human glucocorticoid receptor cDNA
24. Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with glucocorticoid receptor
25. Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems
26. Feedback action and tonic influence of corticosteroids on brain function: A concept arising from the heterogeneity of brain receptor systems
27. Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor
28. Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis
29. Ontogeny of mineralocorticoid (type 1) receptors in brain and pituitary: An in vivo autoradiographical study
30. Steroid hormone receptors: Many actors in search of a plot
31. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element
32. Transactivation and synergistic properties of the mineralocorticoid receptor: Relationship to the glucocorticoid receptor
33. Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
34. Glucocorticoid receptor cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids
35. Functional interactions between Stat5 and the glucocorticoid receptor
36. Steroid hormones use nongenomic mechanisms to control brain functions behaviors: A review of evidence
37. Nongenomic membrane actions of glucocorticoids in vertebrates
38. Stress and cognition: Are corticosteroids good or bad guys
39. Modulatory actions of steroid hormones and neuropeptides on electrical activity in brain
40. Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning
41. The effect of corticosterone on reactivity to spatial novelty is mediated by central mineralocorticosteroid receptors
42. Organization of the stress response at the anatomical level
43. Roles of type I and II corticosteroid receptors in the regulation of basal activity in the hypothalamo-pituitary-adrenal axis during the diurnal trough and peak: Evidence for a nonadditive effect of combined receptor occupation
44. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?
45. Cortisol response to a combined dexamethasone hCRH challenge in patients with depression
46. The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders
47. The dexamethasone/corticotropin-releasing hormone test in depression in bipolar and unipolar affective illness
48. Corticosterone and serotonergic neurotransmission in the hippocampus: Functional implications of central corticosteroid receptor diversity
49. Differential effects of stress on presynaptic and postsynaptic 5-hydroxytryptamine-1A receptors in the rat brain: An in vitro electrophysiological study
50. Do panic disorder and posttraumatic stress disorder share a common psychoneuroendocrinology?
51. Glucocorticoid receptors in depression
52. A neuropharmacologically relevant animal model of depression
53. Chronic mild stress-induced anhedonia: A realistic animal model of depression
54. Validity, reliability and utility of the chronic mild stress model of depression: A 10-year review and evaluation
55. Depression: A new animal model sensitive to antidepressant treatments
56. The tail suspension test: A new method for screening antidepressants in mice
57. Behavioral phenotyping of transgenic and knockout mice: Experimental design and evaluation of health, sensory functions, motor abilities, and specific behavioral tests
58. + metabolism
59. Impaired type II glucocorticoid receptor function in mice bearing antisense RNA transgene
60. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
61. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
62. Deletion of a DNA polymerase b gene segment in T cells using cell type- specific gene targeting
63. Glucocorticoid signalling - Multiple variations of a common theme
64. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1
65. DNA binding of the glucocorticoid receptor is not essential for survival
66. The DNA binding independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin
67. Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock
68. Rescue of the mineralocorticoid receptor knock-out mouse
69. Genetic disruption of mineralocorticoid receptor leads to granule cell degeneration and impaired neurogenesis in the hippocampus of adult mice
70. Antidepressant drug action in transgenic mouse model of the endocrine changes seen in depression
71. Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function
72. Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against glucocorticoid receptor
73. Reduced activity of hypothalamic corticotropin-releasing hormone neurons in transgenic mice with impaired glucocorticoid receptor function
74. Long-term antidepressant treatment reduces behavioral deficits in transgenic mice with impaired glucocorticoid receptor function
75. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: An in vivo microdialysis study in transgenic mice
76. Spatial memory in transgenic mice with impaired glucocorticoid receptor function
77. Corticotropin-releasing factor CRF, but not CRF2 receptors, mediate anxiogenic-like behavior
78. Differential behavioral effects of chronic infusion of CRH1 and CRH2 receptor antisense oligonucleotides into the rat brain
79. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
80. Corticotropin releasing factor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
81. Feedback control of glucocorticoid production is established during fetal development
82. Clinical and biochemical manifestations of depression. Relation to neurobiology of stress (1)
83. Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene
84. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene
85. Hormone-mediated repression: A negative glucocorticoid response element from the bovine prolactin gene
86. Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
87. Do early life events permanently alter behavioral and hormonal responses to stressors?
88. Overproduction of corticotropin-releasing factor in transgenic mice: A genetic model of anxiogenic behavior
89. Increased activity of the hypothalamus-pituitary-adrenal system after treatment with the mineralocorticoid receptor antagonist spironolactone
90. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
91. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone
92. Chronic stress alters synaptic terminal structure in hippocampus
93. Hippocampal atrophy in recurrent major depression
94. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain
95. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
96. A molecular and cellular theory of depression
97. Intact spatial learning and memory in transgenic mice with reduced BDNF
98. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript
99. Anti-depressant-like effect of brain-derived neurotrophic factor (BDNF)
100. Glucocorticoid-biogenic amine interactions in relation to mood and behavior
101. Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin
102. Learned helplessness increases 5-hydroxytryptamine 1B receptor mRNA levels in the rat dorsal raphe nucleus
103. Regulation of serotonin 1A, glucocorticoid and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression
104. Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland
105. Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain
106. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo
107. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system
108. Gene-targeting studies of mammalian behavior: Is it the mutation or the background genotype?
109. Targeting genes and proteins in the analysis of learning and memory: Caveats and future directions