2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4563-4568

  Gangjee, Aleem ^a   Mavandadi, Farahnaz ^a   Kisliuk, Roy L ^b   McGuire, John J ^c   Queener, Sherry F ^d  

^a DUQUESNE UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

^d INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 METHYL 5 (2' NAPHTHYLSULFANYL) 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 (PHENYLSULFANYL) 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [(3',4' DICHLOROPHENYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [(3',4' DIMETHOXYPHENYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO[3,4 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [(4' CHLOROPHENYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [(4' NITROPHENYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDINE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FOLIC ACID ANTAGONIST; METESIND GLUCURONATE; NOLATREXED; PEMETREXED; RALTITREXED; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER GROWTH; CLINICAL TRIAL; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GROWTH INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PNEUMOCYSTIS CARINII; TOXOPLASMA GONDII;

ANIMALS; ENTEROCOCCUS FAECIUM; ENZYME INHIBITORS; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; HUMANS; LACTOBACILLUS CASEI; PNEUMOCYSTIS; PYRIMIDINES; RATS; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0029804033     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960097t     Document Type: Article

References (38)

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