The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae

Molecular Microbiology

Volumn 27, Issue 3, 1998, Pages 643-650

  Didion, Thomas ^a   Regenberg, Birgitte ^a   Jørgensen, Marianne U ^a   Kielland Brandt, Morten C ^a   Andersen, Helge A ^a  

^a CARLSBERG LABORATORY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; LEUCINE; MEMBRANE PROTEIN; PERMEASE;

AMINO ACID TRANSPORT; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE;

AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; CARRIER PROTEINS; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; LEUCINE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

SACCHAROMYCES CEREVISIAE;

EID: 0031963197     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1998.00714.x     Document Type: Article

References (33)

1. André, B. (1995) An overview of membrane transport proteins in Saccharomyces cerevisiae. Yeast 11: 1575-1611.
2. Boeke, J.D., LaCroute, F., and Fink, G.R. (1984) A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol Gen Genet 197: 345-346.
3. Celenza, J.L., Marshall-Carlson, L., and Carlson, M. (1988) The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein. Proc Natl Acad Sci USA 85: 2130-2134.
4. Christianson, T.W., Sikorski, R.S., Dante, M., Shero, J.H., and Hieter, P. (1992) Multifunctional yeast high-copy-number shuttle vectors. Gene 110: 119-122.
5. Didion, T., Grauslund, M., Kielland-Brandt, M.C., and Andersen, H.A. (1996) Amino acids induce expression of BAP2, a branched-chain amino acid permease gene in Saccharomyces cerevisiae. J Bacteriol 178: 2025-2029.
6. Falco, S.C., and Dumas, K.S. (1985) Genetic analysis of mutants of Saccharomyces cerevisiae resistant to the herbicide sulfometuron methyl. Genetics 109: 21-35.
7. Grauslund, M. (1995) Characterization of the BAP2 gene in Saccharomyces cerevisiae. Master's thesis, Institute of Molecular Biology, University of Odense, Denmark.
8. Grauslund, M., Didion, T., Kielland-Brandt, M.C., and Andersen, H.A. (1995) BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiae. Biochim Biophys Acta 1269: 275-280.
9. Grenson, M. (1992) Amino acid transporters in yeast: structure, function and regulation. In Molecular Aspects of Transport Proteins. De Pont, J.J.H.H.M. (ed.). Amsterdam: Elsevier, pp. 219-245.
10. Heitman, J., Koller, A., Kunz, J., Henriquez, R., Schmidt, A., Movva, N.R., et al. (1993) The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. Mol Cell Biol 13: 5010-5019.
11. Horák, J. (1997) Yeast nutrient transporters. Biochim Biophys Acta 1331: 41-79.
12. Island, M.D., Naider, F., and Becker, J.M. (1987) Regulation of dipeptide transport in Saccharomyces cerevisiae by micromolar amino acid concentrations. J Bacteriol 169: 2132-2136.
13. Isnard, A.D., Thomas, D., and Surdin-Kerjan, Y. (1996) The study of methionine uptake in Saccharomyces cerevisiae reveals a new family of amino acid permeases. J Mol Biol 262: 473-484.
14. Jørgensen, M.U., Bruun, M.B., Didion, T., and Kielland-Brandt, M.C. (1997) Mutations in five loci affecting G/AP1-independent uptake of neutral amino acids in yeast. Yeast (in press).
15. Liang, H., and Gaber, R.F. (1996) A novel signal transduction pathway in Saccharomyces cerevisiae defined by Snf3-regulated expression of HXT6. Mol Biol Cell 7: 1953-66.
16. Linger, J., Kellermann, J., and Keller, W. (1991) Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae. Nature 354: 496-498.
17. Ljungdahl, P.O., Gimeno, C.J., Styles, C.A., Fink, G.R. (1992) SHR3: a novel component of the secretory pathway specifically required for localization of amino acid permeases in yeast. Cell 71: 463-478.
18. Mai, B., and Lipp, M. (1994) Cloning and chromosomal organization of a gene encoding a putative amino-acid permease from Saccharomyces cerevisiae. Gene 143: 129-133.
19. Marshall-Carlson, L., Neigeborn, L., Coons, D., Bisson, L., and Carlson, M. (1991) Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant. Genetics 128: 505-512.
20. Mortimer, R.K., and Johnston, J.R. (1986) Genealogy of principal strains of the yeast genetic stock center. Genetics 113: 35-43.
21. Nagawa, F., and Fink, G.R. (1985) The relationship between the 'TATA' sequence and transcription initiation sites at the HIS4 gene of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 82: 8557-8561.
22. Neigeborn, L., Schwartzberg, P., Reid, R., and Carlson, M. (1986) Null mutations in the SNF3 gene of Saccharomyces cerevisiae cause a different phenotype than do previously isolated missense mutations. Mol Cell Biol 6: 3569-3574.
23. Nelissen, B., Mordant, P., Jonniaux, J.-L., De Wachter, R., and Goffeau, A. (1995) Phylogenetic classification of the major superfamily of membrane transport facilitators, as deduced from yeast genome sequencing. FEBS Lett 377: 232-236.
24. Özcan, S., and Johnston, M. (1995) Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol Cell Biol 15: 1564-1572.
25. Özcan, S., Dover, J., Rosenwald, A.G., Wölfl, S., and Johnston, M. (1996) Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc Natl Acad Sci USA 93: 12428-12432.
26. Özcan, S., Vallier, L.G., Flick, J.S., Carlson, M., and Johnston, M. (1997) Expression of the SUC2 gene of Saccharomyces cerevisiae is induced by low levels of glucose. Yeast 13: 127-137.
27. Perry, J.R., Basrai, M.A., Steiner, H.Y., Naider, F., and Becker, J.M. (1994) Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene. Mol Cell Biol 14: 104-115.
28. Reifenberger, E., Freidel, K., and Ciriacy, M. (1995) Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux. Mol Microbiol 16: 157-167.
29. Schmidt, A., Hall, M.N., and Koller, A. (1994) Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Mol Cell Biol 14: 6597-6606.
30. Sikorski, R.S., and Hieter, P. (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
31. Struhl, K., Stinchcomb, D.T., Scherer, S., and Davis, R.W. (1979) High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. Proc Natl Acad Sci USA 76: 1035-1039.
32. Wach, A., Brachat, A., Pöhlmann, R., and Philippsen, P. (1994) New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10: 1793-1808.
33. Wendell, D.L., and Bisson, L.F. (1994) Expression of high-affinity glucose transport protein Hxt2p of Saccharomyces cerevisiae is both repressed and induced by glucose and appears to be regulated posttranslationally. J Bacteriol 176: 3730-3737.