A novel signal transduction pathway in Saccharomyces cerevisiae defined by Snf3-regulated expression of HXT6

Molecular Biology of the Cell

Volumn 7, Issue 12, 1996, Pages 1953-1966

  Liang, Hong ^a   Gaber, Richard F ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL GROWTH; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 0029811217     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.7.12.1953     Document Type: Article

References (46)

1. Ausubel, M.F., Brent, R., Kingston, E.R., Moore, D.D., Seidman, J.G., Smith, A.J., and Struhl, K. (1987). Current Protocols in Molecular Biology, Boston, MA: Wiley Interscience.
2. Baudin, A., Ozier-Kalogeropoulos, O., Denouel, A., Lacroute, F., and Cullin, C. (1993). A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 21, 3329-3330.
3. Becker, D.M., and Guarente, L. (1991). High efficiency transformation of yeast by electroporation. Methods Enzymol. 194, 182-187.
4. Bisson, L.F. (1988). High-affinity glucose transport in Saccharomyces cerevisiae is under general glucose repression control. J. Bacteriol. 170, 4838-4845.
5. Bisson, L.F., Coons, D.M., Kruckeberg, A.L., and Lewis, D.A. (1993). Yeast sugar transporters. Crit. Rev. Biochem. Mol. Biol. 28, 259-308.
6. Bisson, L.F., and Fraenkel, D.G. (1983a). Involvement of kinases in glucose and fructose uptake by Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 80, 1730-1734.
7. Bisson, L.F., and Fraenkel, D.G. (1983b). Transport of 6-deoxy-glucose in Saccharomyces cerevisiae. J. Bacteriol. 155, 995-1000.
8. Bisson, L.F., Neigeborn, L., Carlson, M., and Fraenkel, D.G. (1987). The SNF3 gene is required for high-affinity glucose transport in Saccharomyces cerevisiae. J. Bacteriol. 169, 1656-1662.
9. Celenza, J.L., Marshall-Carlson, L., and Carlson, M. (1988). The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein. Proc. Natl. Acad. Sci. USA 85, 2130-2134.
10. Christianson, T.W., Sikorski, R.S., Dante, M., Shero, J.H., and Hieter, P. (1992). Multifunctional yeast high-copy-number shuttle vectors. Gene 110, 119-122.
11. Coons, D.M., Boulton, R.B., and Bisson, L.F. (1995). Computer-assisted nonlinear regression analysis of the multicomponent glucose uptake kinetics of Saccharomyces cerevisiae. J. Bacteriol. 177, 3251-3258.
12. Entian, K.D., Kopetzki, E., Frohlich, K.U., and Mecke, D. (1984). Cloning of hexokinase isoenzyme PI from Saccharomyces cerevisiae: PI transformants confirm the unique role of hexokinase isoenzyme PII for glucose repression in yeasts. Mol. & Gen. Genet. 198, 50-54.
13. Feinberg, A.P., and Volgelstein, B. (1983). A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132, 6-13.
14. Flick, J.S., and Johnston, M. (1991). GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Mol. Cell. Biol. 11, 5101-5112.
15. Fuhrmann, G.F., and Volker, B. (1993). Misuse of graphical analysis in nonlinear sugar transport kinetics by Eadie-Hofstee plots. Biochim. Biophys. Acta 1145, 180-182.
16. Gaber, R.F., Styles, C.A., and Fink, G.R. (1988). TRK1 encodes a plasma membrane protein required for high-affinity potassium transport in Saccharomyces cerevisiae. Mol. Cell. Biol. 8, 2848-2859.
17. Gamo, F.J., Moreno, E., and Lagunas, R. (1995). The low-affinity component of the glucose transport system in Saccharomyces cerevisiae is not due to passive diffusion. Yeast 11, 1393-1398.
18. Heredia, C.F., Sols, A., and Delafuente, G. (1968). Specificity of the constitutive hexose transport in yeast. Eur. J. Biochem. 5, 321-329.
19. Innis, A.M., Gelfand, H.D., Sninsky, J.J., and White, J.T. (1990). PCR Protocols. A Guide to Methods and Applications, San Diego, CA: Academic Press.
20. Ko, C.H., Liang, H., and Gaber, R.F. (1993). Roles of multiple glucose transporters in Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 638-648.
21. Komachi, K., Redd, M.J., and Johnson, A.D. (1994). The WD repeats of Tup1 interact with the homeo domain protein alpha 2. Genes Dev. 8, 2857-2867.
22. Kruckeberg, A.L. (1996). The hexose transporter family of Saccharomyces cerevisiae. Arch. Microbiol. (in press).
23. Kruckeberg, A.L., and Bisson, L.F. (1990). The HXT2 gene of Saccharomyces cerevisiae is required for high-affinity glucose transport. Mol. Cell. Biol. 10, 5903-5913.
24. Lewis, D.A., and Bisson, L.F. (1991). The HXT1 gene product of Saccharomyces cerevisiae is a new member of the family of hexose transporters. Mol. Cell. Biol. 11, 3804-3813.
25. Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982). Molecular Cloning. A Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
26. Marshall-Carlson, L., Celenza, J.L., Laurent, B.C., and Carlson, M. (1990). Mutational analysis of the SNF3 glucose transporter of Saccharomyces cerevisiae. Mol. Cell. Biol. 10, 1105-1115.
27. Marshall-Carlson, L., Neigeborn, L., Coons, D., Bisson, L., and Carlson, M. (1991). Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant. Genetics 128, 505-152.
28. Nehlin, J.O., Carlberg, M., and Ronne, H. (1989). Yeast galactose permease is related to yeast and mammalian glucose transporters. Gene 85, 313-319.
29. Neigeborn, L., and Carlson, M. (1984). Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics 108, 845-858.
30. Neigeborn, L., Schwartzberg, P., Reid, R., and Carlson, M. (1986). Null mutations in the SNF3 gene of Saccharomyces cerevisiae cause a different phenotype than do previously isolated missense mutations. Mol. Cell. Biol. 6, 3569-3574.
31. Nelissen, B., Mordant, P., Jonniaux, J., Wachter, R., and Goffeau, A. (1995). Phylogenetic classification of the major superfamily of membrane transport facilitators, as deduced from yeast genome sequencing. FEBS Lett. 377, 232-236.
32. Nishizawa, K., Shimoda, E., and Kasahara, M. (1995). Substrate recognition domain of the Gal2 galactose transporter in yeast Saccharomyces cerevisiae as revealed by chimeric galactose-glucose transporters. J. Biol. Chem. 270, 2423-2426.
33. Ozcan, S., Dover, J., Rosenwald, A.G., Woelfl, S., and Johnston, M. (1996). Two glucose transporters in S. cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc. Natl. Acad. Sci. USA (in press).
34. Ozcan, S., and Johnston, M. (1995). Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol. Cell. Biol. 15, 1564-1572.
35. Ozcan, S., Schulte, F., Freidel, K., Weber, A., and Ciriacy, M. (1994). Glucose uptake and metabolism in grr1/cat80 mutants of Saccharomyces cerevisiae. Eur. J. Biochem. 224, 605-611.
36. Reifenberger, E., Freidel, K., and Ciriacy, M. (1995). Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux. Mol. Microbiol. 16, 157-167.
37. Rose, M., Albig, W., and Entian, K. (1991). Glucose repression in Saccharomyces cerevisiae is directly associated with hexose phosphorylation by hexokinase PI and hexokinase PII. Eur. J. Biochem. 199, 511-518.
38. Sanger, F., Nicklen, S., and Coulson, A. (1977). DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.
39. Sherman, F., Fink, G.R., and Hicks, J. (1986). Methods in Yeast Genetics, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
40. Sikorski, R.S., and Heiter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
41. Theodoris, G., Fong, N.M., Coons, D.M., and Bisson, L.F. (1994). High-copy suppression of glucose transport defects by HXT4 and regulatory elements in the promoters of the HXT genes in Saccharomyces cerevisiae. Genetics 137, 957-966.
42. Treitel, M.A., and Carlson, M. (1995). Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proc. Natl. Acad. Sci. USA 92, 3132-3136.
43. Tschopp, J.F., Emr, S.D., Field, C., and Schekman, R. (1986). GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae. J. Bacteriol. 166, 313-318.
44. Vallier, L.G., Coons, D., Bisson, L.F., and Carlson, M. (1994). Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics 136, 1279-1285.
45. Vernet, T., Dignard, D., and Thomas, Y.D. (1987). A family of yeast expression vectors containing the phage f1 intergenic region. Gene 52, 225-233.
46. Wendell, D.L., and Bisson, L.F. (1994). Expression of high-affinity glucose transport protein Hxt2p of Saccharomyces cerevisiae is both repressed and induced by glucose and appears to be regulated posttranslationally. J. Bacteriol. 176, 3730-3737.