Proteasome contributes to the α-secretase pathway of amyloid precursor protein in human cells

Journal of Neurochemistry

Volumn 68, Issue 2, 1997, Pages 698-703

  Marambaud, Philippe ^a   Chevallier, Nathalie ^a   Barelli, Helene ^a   Wilk, Sherwin ^b   Checler, Frederic ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid peptide; Human kidney 293 cells; Proteasome; Secretase; Amyloid precursor protein

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; CHYMOTRYPSIN; LACTACYSTIN; PHORBOL DIBUTYRATE; PROTEASOME; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL;

EID: 0031022252     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68020698.x     Document Type: Article

References (33)

1. Checler F. (1995) Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65, 1431-1444.
2. Efthimiopoulos S., Felsenstein K. M., Sambamurti K., Robakis N. K., and Refolo L. M. (1994) Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. J. Neurosci. Res. 38, 81-90.
3. Esch F. S., Keim P. S., Beattie E. C., Blacher R. W., Culwell A. R., Oltersdorf T., McClure D., and Ward P. J. (1990) Cleavage of amyloid β peptide during constitutive processing of its precursor. Science 248, 1122-1128.
4. Fenteany G., Standaert R., Lane W. S., Choi S., Corey E. J., and Schreiber S. L. (1995) Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268, 726-731.
5. Gillespie S., Golde T. E., and Younkin S. G. (1992) Secretory processing of the Alzheimer amyloid β/A4 protein precursor is increased by protein phosphorylation. Biochem. Biophys. Res. Commun. 187, 1285-1290.
6. Glenner G. G. and Wong C. W. (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890.
7. Goldgaber D., Lerman M. I., McBride O. W., Saffiotti U., and Gajdusek D. C. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235, 877-880.
8. Griscavage J. M., Wilk S., and Ignarro L. J. (1996) Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc. Natl. Acad. Sci. USA 93, 3308-3312.
9. Hough R., Pratt G., and Rechesteiner M. (1987) Purification of two high molecular weight proteases from rabbit reticulocyte lysate. J. Biol. Chem. 262, 8303-8313.
10. Hung A. Y. and Selkoe D. J. (1994) Selective ectodomain phosphorylation and regulated cleavage of β-amyloid precursor protein. EMBO J. 13, 534-542.
11. Hung A. Y., Haass C., Nitsch R. M., Qiu W. Q., Citron M., Wurtman R. J., Growdon J. H., and Selkoe D. J. (1993) Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J. Biol. Chem. 268, 22959-22962.
12. Imajoh-Ohmi S., Kawaguchi T., Sugiyama S., Tanaka K., Omura S., and Kikuchi H. (1995) Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells. Biochem. Biophys. Res. Commun. 217, 1070-1077.
13. Jensen T. J., Loo M. A., Find S., Williams D. B., Goldberg A. L., and Riordan J. R. (1995) Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83, 129-135.
14. Kamikubo T. and Hayashi T. (1996) Changes in proteasome activity following transient ischemia. Neurochem. Int. 28, 209-212.
15. Kang J., Lemaire H.-G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K.-H., Multhaup G., Beyreuther K., and Müller-Hill B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
16. Kojima I. and Oniori M. (1992) Two-way cleavage of β-amyloid protein precursor by multicatalytic proteinase. FEBS Lett. 304, 57-60.
17. Marambaud P., Wilk S., and Checler F. (1996) Protein kinase A phosphorylation of the proteasome: a contribution to the α-secretase pathway in human cells. J. Neurochem. 67, 2616-2619.
18. Masters C. L., Simons G., Weinman N. A., Multhaup G., McDonald B. L., and Beyreuther K. (1985) Amyloid plaque core protein in Alzheimer's disease and Down syndrome. Proc. Natl. Acad. Sci. USA 82, 4245-4249.
19. 2+ homeostasis in Alzheimer's disease. Trends Neurosci. 16, 409-414.
20. McConlongue L., Castellano F., deWit C., Schenk D., and Maltese W. A. (1996) Differential effects of a rabo mutant on secretory versus amyloidogenic processing of Alzheimer's β-amyloid precursor protein. J. Biol. Chem. 271, 1343-1348.
21. Oda K., Ikehara Y., and Omura S. (1996) Lactacystin, an inhibitor of the proteasome, blocks the degradation of a mutant precursor of glycosylphosphatidyl inositol-linked protein in a pre-Golgi compartment. Biochem. Biophys. Res. Commun. 219, 800-805.
22. Oltersdorf T., Fritz L. C., Sehen D. B., Lieberburg I., Johnson-Wood K. L., Beattie E. C., Ward P. J., Blachen R. W., Dovey H. F., and Sinha S. (1989) The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II. Nature 341, 144-147.
23. Orlowski M. and Michaud C. (1989) Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity. Biochemistry 28, 9270-9278.
24. Pereira M. E., Yu B., and Wilk S. (1992) Enzymatic changes of the bovine pituitary multicatalytic proteinase complex, induced by magnesium ions. Arch. Biochem. Biophys. 294, 1-8.
25. Peters J. M. (1994) Proteasomes: protein degradation machines of the cell. Trends Biochem. Sci. 19, 377-382.
26. Qiu W. Q., Ferreira A., Miller C., Koo E. H., and Selkoe D. J. (1995) Cell-surface β-amyloid precursor protein stimulates neunte outgrowth of hippocampal neurons in an isoform-dependent manner. J. Neurosci. 15, 2157-2167.
27. Saitoh T., Sundsmo M., Roch J. M., Kimura N., Cole G., Schubert D., Olsterdorf T., and Schenk D. B. (1989) Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts. Cell 58, 615-622.
28. Schönlein C., Probst A., and Huber G. (1993) Characterization of proteases with (he specificity to cleave at the secretase-site of β-APP. Neurosci. Lett. 161, 33-36.
29. Shoji M., Golde T. E., Ghiso J., Cheung T. T., Estus S., Shaffer M., Cai X. D., McKay D. M., Tintner R., Frangione B., and Younkin S. G. (1992) Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258, 126-129.
30. Sisodia S. S., Koo E. H., Beyreuther K., Unterbeck A., and Price D. L. (1990) Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248, 492-496.
31. a-inhibitor, a form of Alzheimer amyloid precursor protein. Science 248, 1126-1128.
32. Tanzi R. E., Gusella J. F., Watkins P. C., Bruns G. A. P., St. George-Hyslop P., Van Keuren M. L., Patterson D., Pagan S., Kurnit D. M., and Neve R. L. (1987) Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235, 880-884.
33. Ward C. L., Omura S., and Kopito R. R. (1995) Degradation of CFTR by the ubiquitin-proteasome pathway. Cell 83, 121-127.