Use of transgenic mice model for understanding the placentation: Towards clinical applications in human obstetrical pathologies?

Transgenic Research

Volumn 10, Issue 5, 2001, Pages 377-398

  Sapin, Vincent ^a   Blanchon, Loïc ^a   Serre, Anne Françoise ^b   Lémery, Didier ^c   Dastugue, Bernard ^a   Ward, Simon J ^d  

^a INSERM   (France)

^b Faculté de Pharmacie   (France)

^c HÔTEL DIEU   (France)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Choriocarcinoma; Endometriosis; Genetically engineered mice; Implantation; Intra uterine growth retardation; Placenta; Preeclampsia; Trophoblast; Yolk sac

Indexed keywords

ANIMAL MODEL; CHORIOVITELLINE; EMBRYO DEVELOPMENT; GENE TARGETING; MUTAGENESIS; REPRODUCTION; TRANSGENIC MOUSE;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0034777628     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012085713898     Document Type: Review

References (167)

1. Implantation and decidualization in rodents
2. Essential role of p38 alpha MAP, kianse in placental but not embryonic cardiovascular development
3. Molecular approach to intrauterine growth retardation: An overview of recent data
4. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta
5. Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
6. Gestational choriocarcinoma
7. PPAR gamma is required for placental, cardiac, and adipose tissue development
8. Evolution of mammalian pregnancy in the presence of the maternal immune system
9. Fine structural differentiation of germ layers in the mouse at the time of mesoderm formation
10. DNA microarrays: A novel approach to investigate genomics in trophoblast invasion - A review
11. Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice
12. Heritability and molecular genetic studies of endometriosis
13. Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice
14. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
15. A murine model of hereditary hemorrhagic telangiectasia
16. The role of integrins in reproduction
17. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation
18. Altering the genome by homologous recombination
19. Hox genes and mammalian development
20. Role of tissue factor in embryonic blood vessel development
21. Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential for subsequent embryogenesis
22. Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency
23. Hepatocyte growth factor/scatter factor and its receptor c-met: Localisation and expression in the human placenta throughout pregnancy
24. Hepatocyte growth factor levels during normal and intra-uterine growth-restricted pregnancies
25. Role of the thrombin receptor in development and evidence for a second receptor
26. Recurrent pregnancy loss
27. Death before birth: Clues from gene knockouts and mutations
28. Epidemiology of recurrent spontaneous abortion
29. Implantation and the placenta: Key pieces of the development puzzle
30. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V
31. Decay-accelerating factor protects human trophoblast from complement-mediated attack
32. Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo
33. Patholgy of the placenta
34. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice
35. Effect of cytokines and anti-adhesion molecule antibodies on the adhesion of lymphocytic cells to human syncytiotrophoblast
36. Early embryonic mortality in women
37. A prospective study of early pregnancy loss
38. A comparative study of the fine structure in several hemochorial placentas
39. Comparative placental structure
40. Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes
41. Developmental functions of mammalian Hox genes
42. Altered mRNA expression pattern of placnental epidermal growth factor receptor in pregnancies complicated by preeclampsia and/or intrauterine growth retardation
43. Increase in expression and activity of thrombomodulin in term human syncytiotrophoblast microvilli
44. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
45. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1
46. Alterations of human placental epidermal growth factor receptor in intrauterine growth retardation
47. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
48. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
49. Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice
50. Recent advances in the understanding of genetic causes of congenital heart defects
51. Abnormal uterine stromal and glandular function associated with maternal reproductive defects in Hoxa-11 null mice
52. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
53. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
54. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
55. Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
56. Transforming growth factor-beta signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice
57. Essential role of Mash-2 in extraembryonic development
58. Targeted disruption of the murine VCAM1 gene: Essential role of VCAM-1 in chorioallantoic fusion and placentation
59. Pathophysiology, cellular and molecular mechanisms of foetal growth retardation
60. Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality
61. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system
62. Defects in yolk sac hematopoiesis in M11-null embryos
63. Maternal immunological aspects of pregancy success and failure
64. Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
65. Incidence of congenital heart disease: I. Postnatal incidence
66. Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development
67. A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis
68. Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis
69. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation
70. Restricted distribution of tetraploid cells in mouse tetraploid - Diploid chimaeras
71. A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation
72. Ultrastructure studies of protein transfer across rodent yolk sac
73. Functional anatomy of the non-primate placenta
74. Anatomy and genesis of the placenta
75. The differential expression of hepatocyte growth factor and met in human placenta
76. Defective haemochorial placentation as a cause of miscarriage: A preliminary study
77. The transcription factor GATA6 is essential for early extraembryonic development
78. ARNT-deficient mice and placental differentiation
79. Requirement of the mouse I-mfa gene for placental development and skeletal patterning
80. Recurrent pregnancy loss: An update
81. Placental histology and fetal blood flow in intrauterine growth retardation
82. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
83. Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth
84. Defective angiogenesis in mice lacking endoglin
85. Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia
86. Hoxa- 10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse
87. Insulin-like growth factor II affects the appearance and glycogen content of glycogen cells in the murine placenta
88. Manufacture of diploid/tetraploid chimeric mice
89. Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta
90. GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo
91. Genetic control of uterine receptivity during implantation
92. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
93. Fatal gestational choriocarcinoma. Clinicopathologic study of patients treated at a trophoblastic disease center
94. Enginering the mouse genome by site-specific recombination
95. Roles for laminin in embryogenesis: Exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain
96. Recurrent abortion
97. Targeted disruption of the Wnt2 gene results in placentation defects
98. Placental failure in mice lacking the homeobox gene D1x3
99. Retinoids and mammalian development
100. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis
101. Development of trophoblasts and placenta of the mouse
102. Cre recombinase: The universal reagent for genome tailoring
103. The cytotoxicity of DNA carboxymethylation and methylation by the model carboxymethylating agent azaserine in human cells
104. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis
105. Disruption of the mouse RBP-J kappa gene results in early embryonic death
106. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
107. Pathophysiology of intrauterine growth retardation: Role of the placenta
108. A role for hepatocyte growth factor during early postimplantation growth of the placental lineage in mice
109. Proliferation and differentiation of trophoblast in the establishment of the rat chorio-allantoic placenta
110. The Sos1 and Sos2 Ras-specific exchange factors: Differences in placental expression and signaling properties
111. Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells
112. Knockout of the abetalipoproteinemia gene in mice: Reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes
113. Developmental defects in mouse embryos lacking N-cadherin
114. Placental pathology: A neglected link between basic disease mechanisms and untoward pregnancy outcome
115. The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
116. Molecular genetics of implantation in the mouse
117. Mcl-1 deficiency results in peri-implantation embryonic lethality
118. The labyrinthine placenta
119. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the sc1 gene
120. Preeclampsia: What we know and what we do not know
121. Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation
122. Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses
123. Scatter factor/hepatocyte growth factor is essential for liver development
124. JunB is essential for mammalian placentation
125. Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa
126. The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms
127. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
128. The role of leukemia inhibitory factor and interleukin-6 in human reproduction
129. Ontogeny of hepatocyte growth factor (HGF) and its receptor (c-met) in human placenta: Reduced HGF expression in intrauterine growth restriction
130. Clinical Gynecologic Endocrinology and Infertility
131. Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus
132. The bHLH-Zip transcription factor Tfeb is essential for placental vascularization
133. Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality
134. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
135. Roles of mesenchymal-epithelial interactions and hepatocyte growth factor-scatter factor (HGF-SF) in placental development
136. Prothrombin deficiency results in embryonic and neonatal lethality in mice
137. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
138. Expression of constitutively active c-met receptor in human choriocarcinoma
139. Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function
140. Cytokeratins 8 and 19 in the mouse placental development
141. The role of HOX genes in human implantation
142. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
143. Targeted disruption of the murine tissue factor gene results in embryonic lethality
144. Cyclophosphamide-induced teratogenesis in ICR mice: The role of apoptosis
145. An early haematopoietic defect in mice lacking the transcription factor GATA-2
146. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
147. Mice lacking HSP90beta fail to develop a placental labyrinth
148. Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice
149. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL
150. Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection
151. Innear ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
152. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
153. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development
154. Retinoid X receptors are essential for early mouse development and placentogenesis
155. Time of implantation of the conceptus and loss of pregnancy
156. Maternal and embryonic factors associated with prenatal loss in mammals
157. HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice
158. Fibroblast growth factor receptor 2 (FGFR2)- mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
159. A critical role for murine complement regulator crry in fetomaternal tolerance
160. Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice
161. Defective trophoblast function in mice with a targeted mutation of Ets2
162. Embryonic mesodermal defects in alpha 5 integrin-deficient mice
163. Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development
164. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
165. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype?
166. Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality
167. Estimates of human fertility and pregnancy loss