Requirement of the mouse I-mfa gene for placental development and skeletal patterning

EMBO Journal

Volumn 17, Issue 21, 1998, Pages 6276-6288

  Kraut, Norbert ^a,d   Snider, Lauren ^a   Chen, C M Amy ^c   Tapscott, Stephen J ^a,b   Groudine, Mark ^a,b  

^a USA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Gene targeting; Genetic background; I mfa; Skeletal patterning; Trophoblast development

Indexed keywords

HELIX LOOP HELIX PROTEIN; REPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHONDROGENESIS; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO PATTERN FORMATION; GENE DELETION; GENE EXPRESSION; GENE REPRESSION; MOUSE; NONHUMAN; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TROPHOBLAST;

ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE AND BONES; BONE DEVELOPMENT; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; GENOTYPE; HELIX-LOOP-HELIX MOTIFS; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MICE; MICE, KNOCKOUT; MUTATION; MYOGENIC REGULATORY FACTORS; PLACENTA; RNA, MESSENGER; TRANSCRIPTION FACTORS; TROPHOBLASTS;

ANIMALIA; MAMMALIA;

EID: 0032476725     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.21.6276     Document Type: Article

References (57)

1. Bain,G. et al. (1994) E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell, 79, 885-892.
2. Braun,T., Rudnicki,MA., Arnold,H.-H. and Jaenisch,R. (1992) Targeted inactivation of the muscle regulatory gene myf-5 results in abnormal rib development and perinatal death. Cell, 71, 369-382.
3. Burgess,R., Rawls,A., Brown,D., Bradley,A. and Olson,E.N. (1996) Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature, 384, 570-573.
4. Candia,A.F., Hu,J., Crosby,J., Lalley,P.A., Noden,D., Nadeau,J.H. and Wright,C.V.E. (1992) Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development, 116, 1123-1136.
5. Carney,E.W., Prideaux,V., Lye,S.J. and Rossant,J. (1993) Progressive expression of trophoblast-specific genes during formation of mouse trophoblast giant cells in vitro. Mol. Reprod. Dev., 34, 357-368.
6. Chen,C.-M.A., Kraut,N., Groudine,M. and Weintraub,H. (1996) I-mf, a novel myogenic represser, interacts with members of the MyoD family. Cell, 86, 731-741.
7. Chomczynski,P. and Sacchi,N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
8. Copp,A.J. (1994) Genetic models of mammalian neural tube defects. In Neural Tube Defects. Ciba Foundation Symposium No. 181. Wiley, Chichester, pp. 118-143.
9. Copp,A.J. (1995) Death before birth: clues from gene knockouts and mutations. Trends Genet., 11, 87-93.
10. Cross,J.C., Werb,Z. and Fisher,S.J. (1994) Implantation and the placenta: key pieces of the development puzzle. Science, 266, 1508-1518.
11. Cross,J.C., Flannery,M.L., Blanar,M.A., Steingrimsson,E., Jenkins,N.A., Copeland,N.G., Rutter,W.J. and Werb,Z. (1995) Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development, 121, 2513-2523.
12. Cserjesi,P., Brown,D., Ligon,K.L., Lyons,G.E., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Olson,E.N. (1995a) Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development, 121, 1099-1110.
13. Cserjesi,P., Brown,D., Lyons,G.E. and Olson,E.N. (1995b) Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol., 170, 664-678.
14. Deutsch,U., Dressler,G.R. and Gruss,P. (1988) Pax1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development. Cell, 53, 617-625.
15. Ellmeier,W. and Weith,A. (1995) Expression of the helix-loop-helix gene Id3 during murine embryonic development. Dev. Dyn., 203, 163-173.
16. Faria,J.N. and Soares,M.J. (1991) Trophoblast cell differentiation: establishment, characterization, and modulation of a rat trophoblast cell line expressing members of the placental prolactin family. Endocrinology, 129, 2895-2906.
17. Feinberg,A.J. and Vogelstein,B. (1983) A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 132, 6-13.
18. Firulli,A.B., McFadden,D.G., Lin,Q., Srivastava,D. and Olson,E.N. (1998) Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nature Genet., 18, 266-270.
19. Gavrieli,Y., Sherman,Y. and Ben-Sasson,S.A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119, 493-501.
20. Goulding,M.D., Chalepakis,G., Deutsch,U., Erselius,J. and Gruss,P. (1991) Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J., 10, 1135-1147.
21. Guillemot,F.. Nagy,A., Auerbach,A., Rossant,J. and Joyner,A.L. (1994) Essential role of Mash-2 in extraembryonic development. Nature, 371, 333-336.
22. Hogan,B., Beddington,R., Costantini,F.., and Lacy,E. (1994) Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
23. Hollenberg,S.M., Sternglanz,R., Cheng,P.F. and Weintraub,H. (1995) Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol., 15, 3813-3822.
24. Hurlin,P.J., Quéva,C., Koskinen,P.J., Steingrímssan,E., Ayer,D.E., Copeland,N.G., Jenkins,N.A. and Eisenman,R.N. (1995) Mad3 and Mad4: novel Max-interacting transcriptional repressers that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J., 14, 5646-5659.
25. Ilgren,E.B. (1983) Control of trophoblastic growth. Placenta, 4, 307-328.
26. Jan,Y.N. and Jan,L.Y. (1993) HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell, 75, 827-830.
27. Jen,Y., Weintraub,H. and Benezra,R. (1992) Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. Genes Dev., 6, 1466-1479.
28. Kraut,N. (1997) The gene encoding I-mf (Mdfi) maps to human Chromosome 6p21 and mouse Chromosome 17. Mamm. Genome, 8, 618-619.
29. Kraut,N., Frampton,J., McNagny,K.M. and Graf,T. (1994) A functional Ets DNA-binding domain is required to maintain multipotency of hematopoietic progenitors transformed by Myb-Ets. Genes Dev., 8, 33-44.
30. Lee,J.E. (1997) Basic helix-loop-helix genes in neural development. Curr. Opin. Neurobiol., 7, 13-20.
31. Lescisin,K.R., Varmuza,S. and Rossant,J. (1988) Isolation and characterization of a novel trophoblast-specific cDNA in the mouse. Genes Dev., 2, 1639-1646.
32. Liu,Y., Watanabe,H., Nifuji,A, Yamada,Y. Olson,E.N. and Noda,M. (1997) Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. J. Biol. Chem., 272, 29880-29885.
33. Morriss-Kay,G., Wood,H. and Chen,W.H. (1994) Normal neurulation in mammals. In Neural Tube Defects. Ciba Foundation Symposium No. 181, Wiley. Chichester, pp. 51-63.
34. Nagy,A., Gocza,E., Merentes Diaz,E., Prideaux,V.R., Ivanyi,E., Markkula,M. and Rossant,J. (1990) Embryonic stem cells alone are able to support fetal development in the mouse. Development, 110, 815-821.
35. Neubüser,A., Koseki,H. and Balling,R. (1995) Characterization and developmental expression of Pax9, a paired-box-containing gene related to Paxl. Dev. Biol., 170, 701-716.
36. Riley,P., Anson-Cartwright,L. and Cross,J.C. (1998) The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nature Genet., 18, 271-275.
37. Rudnicki,M.A. and Jaenisch,R. (1995) The MyoD family of transcription factors and skeletal myogenesis. BioEssays, 17, 203-209.
38. Rugh,R. (1990) The Mouse, its Reproduction and Development. Oxford University Press, New York.
39. Rupp,R.A.W. and Weintraub,H. (1991) Ubiquitous MyoD transcription at the midblastula transition precedes induction-dependent expression in the presumptive mesoderm. Cell, 65, 927-937.
40. Sasai,Y., Kageyama,R., Tagawa,Y., Shigemoto,R. and Nakanishi,S. (1992) Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev., 6, 2620-2634.
41. Shida,M.M., Ng,YK., Soares,M.J. and Linzer,D.I.H. (1993) Trophoblast-specific transcription from the mouse placental lactogen-I gene promoter. Mol. Endocrinol., 7, 181-188.
42. Shivdasani,R.A., Mayer,E.L. and Orkin,S.H. (1995) Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature, 373, 432-434.
43. Sibilia,M. and Wagner,E.F. (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science, 269, 234-238.
44. Soriano,P., Montgomery,C., Geske,R. and Bradley,A. (1991) Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell, 64, 693-702.
45. Spicer,D.B., Rhee,J., Cheung,W.L. and Lassar,A.B. (1996) Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein twist. Science, 272, 1476-1480.
46. Srivastava,D., Thomas,T, Lin,Q., Kirby,M.L., Brown,D. and Olson,E.N. (1997) Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nature Genet., 16, 154-160.
47. Tanaka,M., Gertsenstein,M., Rossant,J. and Nagy,A. (1997) Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev. Biol., 190, 55-65.
48. Threadgill,D.W. et al. (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science, 269, 230-234.
49. Turner,D. and Weintraub,H. (1994) Expression of achaete scute homologue 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev., 8, 1434-1447.
50. Tybulewicz,V.L.J., Crawford,C.E., Jackson,P.K., Bronson,R.T. and Mulligan,R.C. (1991) Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell, 65, 1153-1163.
51. Wallin,J., Wilting,J., Koseki,H., Fritsch,R., Christ,B. and Balling,R. (1994) The role of Pax-1 in axial skeleton development. Development, 120, 1109-1121.
52. Wang,Y., Benezra,R. and Sassoon,D.A. (1992) Id expression during mouse development: a role in morphogenesis. Dev. Dyn., 194, 222-230.
53. Weintraub,H. (1993) The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell, 75, 1241-1244.
54. Weintraub,H. et al. (1991) The myoD gene family: nodal point during specification of muscle cell lineage. Science, 251, 761-766.
55. Wolf,C., Thisse,C., Stoetzel,C., Thisse,B., Gerlinger,P. and PerrinSchmitt,F.. (1991) The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist gene. Dev. Biol., 143, 363-373.
56. Yoon,J.K., Olson,E.N., Arnold,H.-H. and Wold,B.J. (1997) Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/M\f-5 locus. Dev. Biol., 188, 349-362.
57. Zhuang,Y., Soriano,P. and Weintraub,H. (1994) The helix-loop-helix gene E2A is required for B cell formation. Cell, 79, 875-884.