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Volumn 65, Issue 13, 2000, Pages 4101-4111

Synthesis and evaluation of 1,2,8,8a-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: Impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis

(7) Boger, D L a Santillán, Jr a Searcey, M a Brunette, S R a Wolkenberg, S E a Hedrick, M P a Jin, Q a

a SCRIPPS RESEARCH INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; DUOCARMYCIN SA; RACHELMYCIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; CHEMICAL REACTION; CRYSTAL STRUCTURE; CYCLIZATION; DNA ALKYLATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALKYLATING AGENTS; ALKYLATION; ANTIBIOTICS, ANTINEOPLASTIC; BASE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DNA; DNA, VIRAL; INDICATORS AND REAGENTS; INDOLEQUINONES; INDOLES; LEUCOMYCINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OLIGODEOXYRIBONUCLEOTIDES; PYRROLES; QUINOLONES;

EID: 0034733133 PISSN: 00223263 EISSN: None Source Type: Journal
DOI: 10.1021/jo000297j Document Type: Article

Times cited : (35)

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