Glia-T cell dialogue

Journal of Neuroimmunology

Volumn 107, Issue 2, 2000, Pages 111-117

  Aloisi, Francesca ^a   Serafini, Barbara ^a   Adorini, Luciano ^b  

^a Lab Organ and Syst Pathophysiology   (Italy)

^b ROCHE MILANO RICERCHE   (Italy)

Author keywords

Antigen presentation; Cytokines; Neural cells; Prostaglandins; Th1 Th2

Indexed keywords

CYTOKINE;

ALLERGIC ENCEPHALOMYELITIS; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ASTROCYTE; AUTOIMMUNITY; CONFERENCE PAPER; GLIA CELL; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NERVE CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ASTROCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; DEMYELINATING AUTOIMMUNE DISEASES, CNS; HUMANS; MICROGLIA; NEUROIMMUNOMODULATION;

EID: 0034710339     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00231-9     Document Type: Conference Paper

References (66)

1. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
2. 2 protects cultured neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Brain Res. 663:1994;237-243.
3. Aloisi F., Penna G., Cerase J., Menendez Iglesias B., Adorini L. IL-12 production by central nervous system microglia is inhibited by astrocytes. J. Immunol. 159:1997;1604-1612.
4. Aloisi F., Ria F., Penna G., Adorini L. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation. J. Immunol. 160:1998;4671-4680.
5. 2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling microglia pro- and anti-inflammatory activities. J. Neurosci. Res. 56:1999;571-580.
6. 2 secretion by microglia during antigen presentation to Th1 cells. J. Immunol. 162:1999;1384-1391.
7. Aloisi F., Ria F., Columba-Cabezas S., Hess H., Penna G., Adorini L. Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 restimulation. Eur. J. Immunol. 29:1999;2705-2714.
8. Aloisi F., De Simone R., Columba-Cabezas S., Penna G., Adorini L. Functional maturation of adult mouse microglia into an antigen presenting cell is promoted by GM-CSF and interaction with Th1 cells. J. Immunol. 164:2000;1705-1712.
9. Ando D.G., Clayton J., Kono D., Urban J.L., Sercarz E.E. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 124:1989;132-143.
10. Bauer J., Wekerle H., Lassmann H. Apoptosis in brain-specific autoimmune diseases. Curr. Opin. Immunol. 7:1995;839-843.
11. Becher B., Dodelet V., Fedorowicz V., Antel J.P. Soluble tumor necrosis factor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. J. Clin. Invest. 98:1996;1539-1543.
12. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:1991;108-113.
13. Brodie C., Goldreich N., Haiman T., Kazimirsky G. Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion. J. Neuroimmunol. 81:1998;20-30.
14. Cazevieille C., Muller A., Meynier F., Dutrait N., Bonne C. Protection by prostaglandins from glutamate toxicity in cortical neurons. Neurochem. Int. 24:1994;395-398.
15. Chao C.C., Molitor T.W., Hu S. Neuroprotective role of IL-4 against activated microglia. J. Immunol. 151:1993;1473-1481.
16. Croxford J.L., Triantaphyllopoulos K., Podhajcer O.L., Feldmann M., Baker D., Chernajovsky Y. Cytokine gene therapy in experimental allergic encephalomyelitis by injection of plasmid DNA-cationic liposome complex into the central nervous system. J. Immunol. 160:1998;5181-5187.
17. Cserr H.F., Knopf P.M. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol. Today. 13:1992;507-512.
18. De Simone R., Giampaolo A., Giometto B., Gallo P., Levi G., Peschle C., Aloisi F. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J. Neuropathol. Exp. Neurol. 54:1995;175-187.
19. Di Rosa F., Francesconi A., Di Virgilio A., Finocchi L., Santilio I., Barnaba V. Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis. Eur J. Immunol. 28:1998;1-11.
20. Eddleston M., Mucke L. Molecular profile of reactive astrocytes: implications for their role in neurologic disease. Neuroscience. 54:1993;15-36.
21. Finke D., Brinckmann U.G., ter Meulen V., Liebert U. Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis. J. Virol. 69:1995;5469-5474.
22. Ford A.L., Foulcher E., Lemckert F.A., Sedgwick J.D. Microglia induce CD4 T lymphocyte final effector function and death. J. Exp. Med. 184:1996;1737-1745.
23. Frei K., Siepl C., Groscurth P., Bodmer S., Schwerdel C., Fontana A. Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells. Eur. J. Immunol. 17:1987;1271-1278.
24. Frei K., Lins H., Schwerdel C., Fontana A. Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed. J. Immunol. 152:1994;2720-2728.
25. Furlan R., Poliani P.L., Galbiati F., Bergami A., Grimaldi L.M.E., Comi G., Adorini L., Martino G. Central nervous system delivery of interleukin-4 by a non-replicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination. Hum. Gene Ther. 9:1998;2605-2617.
26. Gately M.K., Renzetti L.M., Magram J., Stern A.S., Adorini L., Gubler U., Presky D.H. The interleukin-12/interleukin-12 receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:1998;495-521.
27. Gehrmann J., Matsumoto Y., Kreutzberg G.W. Microglia: intrinsic immuneffector cell of the brain. Brain Res. Rev. 20:1995;269-287.
28. Gerritse K., Laman J.D., Noelle R.J., Aruffo A., Ledbetter J.A., Boersma W.J.A., Claassen A. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. USA. 93:1996;2499-2504.
29. Hafler D.A., Weiner H.L. Immunologic mechanisms and therapy in multiple sclerosis. Immunol. Rev. 144:1995;75-107.
30. Hailer N.P., Heppner F.L., Haas D., Nitsch R. Astrocytic factors deactivate antigen presenting cells that invade the central nervous system. Brain Pathol. 8:1998;459-474.
31. Hickey W.F., Kimura H. Perivascular microglial cells of the CNS are bone-marrow derived and present antigen in vivo. Science. 239:1988;290-292.
32. 2 at priming of naive CD4 T cells inhibits acquisition of ability to produce IFN-γ and IL-2, but not IL-4 and IL-5. J. Immunol. 155:1995;4604-4612.
33. Kennedy M.K., Torrance D.S., Picha K.S., Mohler K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:1992;2496-2505.
34. Khoury S.J., Hancock W.W., Weiner H.L. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E in the brain. J. Exp. Med. 176:1992;1355-1364.
35. Kiefer R., Schweitzer T., Jung S., Toyka K.W., Hartung H.P. Sequential expression of transforming growth factor-beta 1 by T cells, macrophages, and microglia in rat spinal cord during autoimmune inflammation. J. Neuropathol. Exp. Neurol. 57:1998;385-395.
36. Komatsu T., Barna M., Reiss C.S. Interleukin-12 promotes recovery from viral encephalitis. Viral Immunol. 10:1997;35-47.
37. + T cell cytokine profile in experimental allergic encephalomyelitis. Eur J. Immunol. 27:1997;2840-2847.
38. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:1996;312-318.
39. Irani D.N., Lin K.-I., Griffin D.E. Regulation of brain-derived T cells during acute central nervous system inflammation. J. Immunol. 158:1997;2318-2326.
40. Issazadeh S., Ljungdahl Å., Hojeberg B., Mustafa M., Olsson T. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, tumor necrosis factor α and tumor necrosis factor β J. Neuroimmunol. 61:1995;205-212.
41. Loughlin A.J., Woodroofe M.N., Cuzner M.L. Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids. Immunology. 79:1993;125-130.
42. Matsumoto Y., Hanawa H., Tsuchida M., Abo T. In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis. The role of astrocytes. Immunology. 79:1993;381-388.
43. Mathisen P.M., Yu M., Johnson J.M., Drazba J.A., Tuohy V.K. Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells. J. Exp. Med. 186:1997;159-164.
44. Meinl E., Aloisi F., Ertl B., Weber F., De Waal Malefyt R., Wekerle H., Hohlfeld R. Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells. Brain. 117:1994;1323-1330.
45. 2 and cyclic AMP-elevating agents. J. Neuroimmunol. 66:1997;1409-1417.
46. Merrill J.E., Benveniste E.N. Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 19:1996;331-338.
47. Minghetti L., Levi G. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Progr. Neurobiol. 54:1998;99-125.
48. Mitchell J.A., Larkin S., Williams T.J. Cyclooxygenase-2: regulation and relevance in inflammation. Biochem. Pharmacol. 50:1995;1535-1542.
49. Morris M.M., Dyson H., Baker D., Harbige L.S., Fazakerley J.K., Amor S. Characterization of the cellular and cytokine response in the central nervous system following Semliky Forest virus infection. J. Neuroimmunol. 74:1997;185-197.
50. Mosmann T.R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today. 17:1996;138-146.
51. Parra B., Hinton D.R., Lin M.T., Cua D.J., Stohlman S.A. Kinetics of cytokine mRNA expression in the central nervous system following lethal and nonlethal coronavirus-induced acute encephalomyelitis. Virology. 233:1997;260-270.
52. Pope J.G., Karpus W.J., Vanderlugt C.L., Miller S.D. Flow cytometric and functional analyses of central nervous system-infiltrating cells in SJL/J mice with Theiler's virus-induced demyelinating disease. Evidence for CD4+ T-cell mediated pathology. J. Immunol. 156:1996;4050-4058.
53. Pope J.G., Vanderlugt C.L., Rahbe S.M., Lipton H.L., Miller S.D. Characterization of and functional antigen presentation by central nervous system mononuclear cells from mice infected with Theiler's murine encephalomyelitis virus. J. Virol. 72:1998;7762-7771.
54. Ransohoff R.M. Chemokines in neurological disease models: correlation between chemokine expression patterns and inflammatory pathology. J. Leukoc. Biol. 62:1997;645-652.
55. Reder A.T., Thapar M., Sapugay A.M., Jensen M. Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis. J. Neuroimmunol. 54:1994;117-127.
56. Sato S., Reiner S.L., Jensen M.A., Roos R.P. Central nervous system cytokine mRNA expression following Theiler's murine encephalomyelitis virus infection. J. Neuroimmunol. 76:1997;213-223.
57. Sedgwick J.D., Ford A.L., Foulcher E., Airriess R. Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts. J. Immunol. 160:1998;5320-5330.
58. Shrikant P., Benveniste E.N. The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation. J. Immunol. 157:1996;1819-1822.
59. Simpson J.E., Newcombe J., Cuzner M.L., Woodroofe M.N. Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J. Neuroimmunol. 84:1998;238-249.
60. Stalder A.K., Pagenstecher A., Yu N.C., Kincaid C., Chiang C.S., Hobbs M.V., Bloom F.E., Campbell I.L. Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia. J. Immunol. 159:1997;1344-1351.
61. Swain S.L., Croft M., Dubey C., Haines L., Rogers P., Zhang X., Bradley L.M. From naive to memory T cells. Immunol. Rev. 150:1996;143-167.
62. Vass K., Lassmann H. Intrathecal application of interferon gamma: progressive appearance of MHC antigens within the rat nervous system. Am. J. Pathol. 137:1990;789-800.
63. Williams K., Ulvestad E., Cragg L., Blain M., Antel J.P. Induction of primary T cell responses by human glial cells. J. Neurosci. Res. 36:1993;382-390.
64. Windhagen A., Newcombe J., Dangond F., Strand C., Woodroofe M.N., Cuzner M.L., Hafler D.A. Expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J. Exp. Med. 182:1995;1985-1996.
65. Woodroofe M.N., Cuzner M.L. Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization. Cytokine. 5:1993;583-588.
66. 2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J. Immunol. 161:1998;2723-2730.