Flow cytometric and functional analyses of central nervous system-infiltrating cells in SJL/J mice with Theiler's virus-induced demyelinating disease: Evidence for a CD4+ T cell-mediated pathology

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 4050-4058

  Pope, Jonathan G ^a   Karpus, William J ^a   Vanderlugt, Carol ^a   Miller, Stephen D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CELLULAR IMMUNITY; DEMYELINATING DISEASE; FEMALE; FLOW CYTOMETRY; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRAIN DIFFERENCE;

ANIMALS; ANTIGENS, CD44; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; POLIOMYELITIS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, INTERLEUKIN-2; THEILOVIRUS;

EID: 0029963947     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Pevear, D. C., M. Calenoff, E. Rozhon, and H. L Lipton. 1987. Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses. J. Virol. 61: 1507.
2. Lipton, H. L 1978 Characterization of the TO strains of Theiler's mouse encephalomyelitis viruses. Infect. Immun. 20.869.
3. Lipton, H. L., and M. C. Dal Canto. 1979. The TO strains of Theiler's viruses cause "slow virus-like" infections in mice. Ann. Neurol 6:25
4. Lipton, H. L., and M. C. Dal Canto. 1979. Susceptibility of inbred mice co chronic central nervous system infection by Theiler's murine encephalomyelitis virus. Infect. Immun 26:369.
5. Dal Canto, M. C . and H. L Lipton. 1975. Primary demyelination in Theiler's virus infection: an ultrastructural study. Lab. Invest. 33:626.
6. Dal Canto, M. C., R. W Melvold, B. S. Kim, and S. D Miller. 1995. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection-α pathological and immunological comparison. Microsc. Res. Technol. 32:215.
7. Lipton, H. L., J. Kratochvil, P. Sethi, and M C. Dal Canto. 1984. Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection. Neurology 34:1117.
8. Lipton, H. L., and M. C. Dal Canto. 1977. Contrasting effects of immunosuppression on Theiler's virus infection in mice. Infect. Immun. 15.903.
9. Lipton, H. L., and M. C. Dal Canto. 1976. Theiler's virus-induced demyelination: prevention by immunosuppression. Science 192:62.
10. Welsh, C. J., P. Tonks, A. A. Nash, and W. F. Blakemore. 1987. The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice. J. Gen. Virol. 68:1659.
11. + T cell line specific for an immunodominant VP2 epitope. J Immunol. 152.919.
12. Friedmann, A., G. Frankel, Y. Lorch, and L. Steinman. 1987. Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: critical importance of timing of treatment J. Virol 61:898.
13. Clatch, R. J., H. L. Lipton, and S. D. Miller. 1986. Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs. J. Immunol. 136.920.
14. Clatch, R J , H L. Lipton, and S. D. Miller. 1987. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II Survey of host immune responses and central nervous system virus titers in inbred mouse strains Microb Pathog. 3:327.
15. Clatch, R. J., R. W. Melvold, S. D Miller, and H L. Lipton. 1985 Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TMEV-specific delayed-type hypersensitivity. J. Immunol. 135 1408.
16. Lipton, H. L., S. D. Miller, R. W. Melvold, and R. S Fujinami. 1986. Theiler's murine encephalomyelitis virus (TMEV) infection in mice as a model for multiple sclerosis In Concepts in Viral Pathogenesis 2. A. L. Notkins and M. B. A. Oldstone, eds. Springer-Verlag, New York, p. 248.
17. Traugott, U , E. L. Reinherz, and C. S. Raine. 1983 Multiple sclerosis: distribution of T cell subsets within active chronic lesions Science 219:308.
18. Hauser, S. L., A. K. Bhan, F. Gilles, M. Kemp, C. Kerr, and H. L Weiner. 1986. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann. Neurol. 19.578.
19. Kurtzke, J. F. 1993. Epidemiologic evidence for multiple sclerosis as an infection. Clin. Microbiol. Rev. 6.382.
20. Ebers, G. C., A. D. Sadovnick, and N J. Risch. 1995 A genetic basis for familial aggregation in multiple sclerosis. Nature 377:150.
21. Challoner, P. B., K. T Smith, J D Parker, D. L. MacLeod, S. N. Coulter, T. M. Rose, E. R. Shultz, J L. Bennett, R. L. Garber, M. Chang, P. A. Schad, P. M. Stewart, R. C. Nowinski, J. P. Brown, and G C. Burmer. 1995. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc. Natl Acad. Sci. USA 92:7440.
22. Hauser, S. L , E L Reinherz, C. J. Hoban, S F. Schlossman, and H. L. Weiner. 1983. CSF cells in multiple sclerosis: monoclonal antibody analysis and relationship to peripheral blood T-cell subsets. Neurology 33:575.
23. Zabriskie, J. B , L. Mayer, S. M Fu, C. Yeadon, V. Cam, and C. Plank. 1985. T-cell subsets in multiple sclerosis: lack of correlation between helper and suppressor T cells and the clinical state J. Clin. Immunol. 5:7.
24. Morimoto, C., D. A. Hafler, H. L Weiner, N. L. Letvin, M Hagen, J. Daley, and S. F. Schlossman 1987. Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. N Engl. J. Med. 316:67.
25. Clatch, R. J , S. D. Miller, R Metzner, M. C Dal Canto, and H. L Lipton 1990. Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virology 176.244.
26. Lindsley, M D., and M Rodriguez. 1989 Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler's virus. J Immunol. 142:2677
27. Onega, G, R J Robb, E. M. Shevach, and T. R. Malek 1984. The murine IL 2 receptor I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J. Immunol. 133:1970.
28. Malek, T. R., G Ortega, J. P. Jakway, C. Chan, and E. M. Shevach. 1984. The murine IL 2 receptor. II. Monoclonal anti-IL 2 receptor antibodies as specific inhibitors of T cell function in vitro. J. Immunol 133:1976.
29. Cerottini, J. C., and H. R. MacDonald 1989. The cellular basis of T-cell memory. Annu Rev Immunol. 7:77.
30. Lipton, H. L., and M C Dal Canto 1976. Chronic neurologic disease in Theiler's virus infection of SJL/J mice. J Neurol. Sci. 30:201.
31. Clatch, R. J , R. W. Melvold, M. C Dal Canto, S. D. Miller, and H. L. Lipton. 1987. The Theiler's murine encephalomyelitis virus (TMEV) model for multiple sclerosis shows a strong influence of the murine equivalents of HLA-A, B, and C. J Neuroimmunol. 15:121
32. Steiner, C. M , E. J. Rozhon, and H. L. Lipton 1984 Relationship between host age and persistence of Theiler's virus in the central nervous system of mice. Infect. Immun. 43:432.
33. McRae, B. L , M. K. Kennedy, L. J. Tan, M. C. Dal Canto, and S D Miller 1992. Induction of active and adoptive chronic-relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein. J. Neuroimmunol. 38:229
34. Kaplan, D. R., V. L. Braciale, and T J Braciale. 1984. Antigen-dependent regulation of interleukin 2 receptor expression on cloned human cytotoxic T lymphocytes J. Immunol 133:1966.
35. - T lymphocytes. J. Immunol. 127:1420.
36. Zamvil, S S., D. J. Mitchell, N. E. Lee, A. C. Moore, M. K. Waldor, K. Sakai, I. B. Rothbard, H. O. McDevitt, L. Steinman, and H. Acha-Orbea. 1988. Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis. J. Exp. Med. 167:1586.
37. Burns, F. R., X. B. Li, N. Shen, H. Offner, Y. K. Chou, A A. Vandenbark, and E Heber-Katz. 1989. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med. 169:27.
38. Offner, H., A. C. Buenafe, M. Vainiene, B Celnik, A. D. Weinberg, D. P. Gold, G. Hashim, and A. A. Vandenbark. 1993. Where, when, and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis. J. Immunol. 151:506.
39. Rodriguez, M., A. K. Patick, L. R Pease, and C. S. David. 1992. Role of T cell receptor V beta genes in Theiler's virus-induced demyelination of mice. J. Immunol. 148:921.
40. + T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice. J. Gen. Virol. 73:1861.
41. Rodnguez, M , and S Sriram. 1988. Successful therapy of Theiler's virus-induced demyelination (DA Strain) with monoclonal anti-Lyt-2 antibody. J. Immunol. 140:2950.
42. Minami, Y., T. Kono, T. Miyazaki, and T. Taniguchi. 1993. The IL-2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol 11:245.
43. 1 integrin. Nature 356.63.
44. Rodriguez, M., W. P. Lafuse, J. Leibowitz, and C. S. David. 1986. Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens)). Neurology 36:964.
45. Peterson, J. D., C. Waltenbaugh, and S. D. Miller. 1992. IgG subclass responses to Theiler's murine encephalomyelitis virus infection and immunization suggest a dominant role for Th1 cells in susceptible mouse strains Immunology 75:652.
46. Coutelier, J. P., J. T van der Logt, F. W. Heessen, A Vink, and J. van Snick 1988, Virally induced modulation of murine IgG antibody subclasses. J. Exp. Med. 168:2373.
47. Gerety, S. J., W . J. Karpus, A. R. Gibbon, R. G. Goswami, M. K. Rundell, J. D. Peterson, and S. D. Miller. 1994. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice. J. Immunol. 152:908.
48. Peterson, J. D., W J. Karpus, R. J. Clatch, and S. D. Miller. 1993. Split tolerance of Th1 and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus. Eur. J. Immunol. 23:46.
49. + Th1 but not Th2 cytokine responses. Int. Immunol. 6:721.
50. Karpus, W. J., J. G. Pope, J. D. Peterson, M. C. Dal Canto, and S. D. Miller. 1995. Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction. J. Immunol. 155:947.
51. Pullen, L., S. D. Miller, M. C Dal Canto, and B. S. Kim. 1993. Class I-deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination. Eur. J. Immunol. 23:2287.
52. 2-microglobulin-deficient mice. J. Virol. 67:589.
53. 2-microglobulin. J Immunol. 151:266
54. Pelka, A., C. Olsberg, S. Miller, C Waltenbaugh, T. M. Creighton, M. C Dal Canto, and R. Melvold. 1993 Effects of irradiation on development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in genetically resistant mice. Cell. Immunol. 152:440.
55. + lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice. J Immunol. In press.
56. Lindsley, M. D., R. Thiemann, and M Rodriguez 1991 Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus. J. Virol. 65:6612.
57. Lindsley, M. D., R. L. Thiemann, and M. Rodriguez. 1988 Enumeration and distribution of T-cell subsets, macrophages, and IgG positive cells in the CNS of SJL/J mice infected with Theiler's virus. Ann. NY Acad. Sci. 540:657.
58. Rodriguez, M , N Prayoonwiwat, P. Zhou, and C. David. 1993. Expression of T cell receptor V beta transcripts in central nervous system of mice susceptible and resistant to Theiler's virus-induced demyelination. J. Neuroimmunol. 47:95.
59. Sobel, R. A., and V. K. Kuchroo. 1992. The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. J. Immunol. 149.1444.
60. Traugott, U. 1989. Detailed analysis of early immunopathologic events during lesion formation in acute experimental autoimmune encephalomyelitis. Cell Immunol 119:114.
61. Matsumoto, Y., H. Hanawa, M. Tsuchida, and T Abo. 1993. In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis: the role of astrocytes. Immunology 79:381.
62. + T cells that induce experimental allergic encephalomyelitis. J Neuroimmunol 40:57.
63. Allen, S. J., D Baker, J. K. O'Neill, A. N Davison, and J. L. Turk 1993. Isolation and characterization of cells infiltrating the spinal cord during the course of chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse. Cell. Immunol. 146:335.
64. Barten, D. M., R. B. Clark, and N. H. Ruddle. 1995. Presence of T cells with activated and memory phenotypes in inflammatory spinal cord lesions. J. Immunol. 155:5409.
65. Miller, S. D., R. J. Clatch, D. C. Pevcar, J. L. Trotter, and H. L. Lipton. 1987 Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins. J. Immunol. 138:3776.
66. Miller, S. D., S J. Gerety, M. K. Kennedy, J D. Peterson, J. L Trotter, V. K Tuohy, C. Waltenbaugh, M C. Dal Canto, and H L. Lipton. 1990. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination. J. Neuroimmunol. 26:9
67. Lehrich, J. R , B. G. W. Arnason, and F. Hochberg. 1976. Demyelinative myelopathy in mice induced by the DA virus. J. Neurol. Sci. 29.149
68. Dal Canto, M. C., and H. L. Lipton. 1982. Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection. Am. J. Pathol. 106:20.