Enforced CD19 expression leads to growth inhibition and reduced tumorigenicity

Blood

Volumn 94, Issue 10, 1999, Pages 3551-3558

  Mahmoud, Maged S ^a   Fujii, Ryuichi ^a   Ishikawa, Hideaki ^a   Kawano, Michio M ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CELL SURFACE PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENICITY; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

EID: 0033571259     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.10.3551.422k08_3551_3558     Document Type: Article

References (23)

1. Pico JL, Castagna L, Bourhis JH: Recent progress in the biology of multiple myeloma and future directions in the treatment. Hematol Cell Ther 40:45, 1998
2. Harada H, Kawano MM, Huang N, Harada Y, Iwato K, Tanabe O, Tanaka H, Sakai A, Asaoku H, Kuramoto A: Phenotypic difference of normal plasma cells from mature myeloma cells. Blood 81:2658, 1993
3. Mahmoud MS, Huang N, Nobuyoshi M, Lisukov IA, Tanaka H, Kawano MM: Altered expression of Pax-5 gene in human myeloma cells. Blood 87:4311, 1996
4. Nadler LM, Anderson KC, Marti G, Bates M, Park E, Daley JF, Schlossman SF: B4, a human B lymphocyte-associated antigen expressed on normal, mitogen activated, and malignant B lymphocytes. J Immunol 131:244, 1983
5. Stamenkovic I, Seed B: CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail. J Exp Med 168:1205, 1988
6. Tedder TF, Isaacs CM: Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. J Immunol 143:712, 1989
7. Zhou LJ, Ord DC, Hughes AL, Tedder TF: Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. J Immunol 147:1424, 1991
8. Matsumoto AK, Kopicky-Burd J, Carter RH, Tuveson DA, Tedder TF, Fearon DT: Intersection of the complement and immune systems: A signal transduction complex of the B lymphocyte containing complement receptor type 2 and CD19. J Exp Med 173:55, 1991
9. Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody and Leu-13 molecules. J Immunol 149:2841, 1992
10. Rickert RC, Rajewsky K, Roes J: Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376:352, 1995
11. Fehr T, Rickert RC, Odermatt B, Roes J, Rajewsky K, Hengartner H, Zinkernagel RM: Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19. J Exp Med 188:145, 1998
12. Callard RE, Rigley KP, Smith SH, Thurstan S, Shields JG: CD19 regulation of human B cell responses. B cell proliferation and antibody secretion are inhibited or enhanced by ligation of the CD19 surface glycoprotein depending on the stimulating signal used. J Immunol 148:2983, 1992
13. Carter RH, Fearon DT: CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256:105, 1992
14. Carter RH, Tuveson DA, Park DJ, Rhee SG, Fearon DT: The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein kinase-dependent pathway that can be enhanced by the membrane IgM complex. J Immunol 147:3663, 1991
15. Tuveson DA, Carter RH, Soltoff SP, Fearon DT: CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260:986, 1993
16. Bondeva T, Pirola L, Bulgarelli-Leva G, Rubio I, Wetzeker R, Wymann MP: Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK. Science 282:293, 1998
17. Chalupny NJ, Kanner SB, Schieven GL, Wee SF, Gilliland LK, Aruffo A, Ledbetter JA: Tyrosine phosphorylation of CD19 in pre-B and mature B cells. EMBO J 12:2691, 1993
18. O'Rourke LM, Tooze R, Turner M, Sandoval DM, Carter RH, Tybulewicz VLJ, Fearon DT: CD19 as a membrane-anchored adaptor protein of B lymphocytes: Costimulation of lipid and protein kinases by recruitment of Vav. Immunity 8:635, 1998
19. Ohtsuki T, Yawata Y, Namba M: Cell growth kinetics of cultured human myeloma cell lines, KMM-1 and KMS-5. Acta Haematol Jpn 51:1052, 1988
20. Nilsson K, Bennich A, Johansson SGO, Pontent J: Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient. Clin Exp Immunol 7:477, 1970
21. Kawano MM, Huang N, Harada H, Harada Y, Sakai A, Tanaka H, Iwato K, Kuramoto A: Identification of immature and mature myeloma cells in the bone marrow of human myelomas. Blood 82:564, 1993
22. Katsume A, Miyai T, Suzuki H, Moriguchi Y, Kawata H, Tatsumi T, Suematsu S, Kishimoto T, Ohsugi Y: Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice. Clin Immunol Immunopathol 82:117, 1997
23. Mahmoud MS, Ishikawa H, Fujii R, Kawano MM: Induction of CD45 expression and proliferation in U-266 myeloma cell line by interleukin-6 (IL-6). Blood 92:3887, 1998