Dominant-negative activity of an α(1β)-adrenergic receptor signal-inactivating point mutation

EMBO Journal

Volumn 19, Issue 16, 2000, Pages 4265-4271

  Chen, Songhai ^a   Lin, Fang ^a   Xu, Ming ^a   Hwa, John ^c   Graham, Robert M ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Constitutive activity; G protein coupled receptor; Inositol phosphate signalling

Indexed keywords

ALPHA 1B ADRENERGIC RECEPTOR; ASPARAGINE; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PHENYLALANINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENETIC CONSERVATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR GENE; SIGNAL TRANSDUCTION; STOICHIOMETRY;

ADRENERGIC ALPHA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; ASPARAGINE; CONSERVED SEQUENCE; COS CELLS; CYCLIC AMP; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; GENES, DOMINANT; GLYCINE; GTP-BINDING PROTEINS; HYDROLYSIS; IMMUNOBLOTTING; INOSITOL PHOSPHATES; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PHOSPHATIDYLINOSITOLS; POINT MUTATION; PRECIPITIN TESTS; PROTEIN BINDING; RECEPTORS, ADRENERGIC, ALPHA-1; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA;

EID: 0034663812     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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