Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

Biochemistry

Volumn 36, Issue 19, 1997, Pages 5769-5776

  Hazra, Tapas K ^a   Roy, Rabindra ^a   Biswas, Tapan ^a   Giabowski, David T ^a,b   Pegg, Anthony E ^c   Mitra, Sankar ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; DNA METHYLTRANSFERASE; DNA; DRUG DERIVATIVE; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE; OLIGONUCLEOTIDE; PROTEINASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; DNA ALKYLATION; GENE MUTATION; KINETICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; BINDING SITE; BIOSYNTHESIS; DNA FOOTPRINTING; DRUG EFFECT; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYMOLOGY; ESCHERICHIA COLI; GENE DELETION; GENETICS; HUMAN; HYDROLYSIS; METABOLISM; SITE DIRECTED MUTAGENESIS;

BINDING SITES; DNA; DNA FOOTPRINTING; ENDOPEPTIDASES; ENZYME STABILITY; ESCHERICHIA COLI; GUANINE; HUMANS; HYDROLYSIS; METHYLTRANSFERASES; MUTAGENESIS, SITE-DIRECTED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OLIGONUCLEOTIDES; SEQUENCE DELETION; SUBSTRATE SPECIFICITY;

EID: 0030610514     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi963085i     Document Type: Article

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