Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents

Advanced Drug Delivery Reviews

Volumn 26, Issue 2-3, 1997, Pages 105-118

  Dolan, M Eileen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Alkylating agents; Alkyltransferase; BCNU; Chemotherapy; DNA repair; O6 Benzylguanine

Indexed keywords

CELLS; DNA; ENZYMES; MOLECULAR WEIGHT; SUBSTRATES; TOXICITY;

ALKYLATING AGENTS; ALKYLTRANSFERASE;

DRUG THERAPY;

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; 6 O METHYLGUANINE; ALKYLATING AGENT; CARMUSTINE; FOTEMUSTINE; GUANINE DERIVATIVE; LOMUSTINE; STREPTOZOCIN; TEMOZOLOMIDE;

ANTINEOPLASTIC ACTIVITY; CANCER; CANCER RESISTANCE; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; DRUG EFFICACY; ENZYME ACTIVITY; HUMAN; MODULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0031558241     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(97)00028-8     Document Type: Review

References (134)

1. J.E. McCormick, R.S. McElhinney, Nitrosoureas from chemist to physician: classification and recent approaches to drug design, Eur. J. Cancer 26 (1990) 207-221.
2. M. Colvin, B.A. Chabner, Alkylating Agents, in: B.A. Chabner, J.M. Collins (Eds.), Cancer Chemotherapy Principles and Practice, J.B. Lippincott, Philadelphia, 1990, pp. 276-313.
3. E.S. Newlands, G.P. Blackledge, J.A. Slack, G.J.S. Rustin, D.B. Smith, N.S.A. Stuart, C.P. Quarterman, R. Hoffman, M.F.G. Stevens, M.H. Brampton, A.C. Gibson, Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856), Br. J. Cancer 65 (1992) 287-291.
4. C.H. Chang, J. Horton, D. Schoenfield, O. Salazer, R. Perez-Tamayo, S. Kramer, A. Weinstein, J.S. Nelson, K. Tsukuda, Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas, Cancer 52 (1985) 997-1007.
5. A.S. Coates, Systemic chemotherapy for malignant melanoma, World J. Surg. 16 (1992) 277-281.
6. J.F. Boivin, G.B. Hutchison, A.G. Zauber, L. Bernstein, F.G. Davis, R.P. Michel, B. Zanke, C.T. Tan, L.M. Fuller, P. Mauch, Incidence of second cancers in patients treated for Hodgkin's disease, J. Natl. Cancer Inst. 87 (1995) 732-741.
7. M.A. Smith, R.P. McCaffrey, J.E. Karp, The secondary leukemias: challenges and research directions, J. Natl. Cancer Inst. 88 (1996) 407-418.
8. B. Singer, J.M. Essigmann, Site-specific mutagenesis: retrospective and prospective, Carcinogenesis 12 (1991) 949-955.
9. R. Saffhill, G.P. Margison, P.J. O'Connor, Mechanism of carcinogenesis induced by alkylating agents, Biochim. Biophys. Acta 823 (1985) 111-145.
10. K.W. Kohn, Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas, Cancer Res. 37 (1977) 1450-1454.
11. 1-deoxyguanosinyl]-ethane, in DNA treated with N,N′-bis(2-chloroethyl-N-nitrosourea (BCNU), Cancer Res. 42 (1982) 3102-3105.
12. D.B. Ludlum, DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal, Mutat. Res. 233 (1990) 117-126.
13. A. Lemoine, C. Lucas, R.M. Ings, Metabolism of the chloroethylnitrosoureas, Xenobiotica 21 (1991) 775-791.
14. 6-methylguanine-DNA methyltransferase, Nucleic Acids Res. 11 (1983) 7743-7758.
15. 6-alkylguanine-DNA-alkyltransferase from human leukemic cells: prevention of chloroethylnitrosourea-induced cross-links by purified enzyme, Pharmacol. Ther. 31 (1985) 121-140.
16. 6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate, Cancer Res. 48 (1988) 3603-3606.
17. W.J. Bodell, K. Tokuda, D.B. Ludlum, Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated with N-(2-chloroethyl)-N-nitrosourea, Cancer Res. 48 (1988) 4489-4492.
18. 6-alkylguanine-DNA alkyltransferase, Prog. Nucleic Acid Res. Mol. Biol. 51 (1995) 167-223.
19. S. Mitra, B. Kaina, Regulation of repair of alkylation damage in mammalian genomes, Prog. Nucleic Acid Res. Mol. Biol. 44 (1993) 109-142.
20. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents, Cancer Res. 50 (1990) 6119-6129.
21. 6-alkyltransferase (AT) in cancer chemotherapy, Cancer Treat. Rev. 15 (1988) 279-292.
22. M. Sekiguchi, Y. Nakabeppu, K. Sakumi, T. Tuzuki, DNA-repair methyltransferase as a molecular device for preventing mutation and cancer, J. Cancer Res. Clin. Oncol. 122 (1996) 199-206.
23. 6-alkylguanine-DNA-alkyltransferase from rat liver and E. coli, Carcinogenesis 6 (1985) 1027-1031.
24. 6-alkylguanine-DNA alkyltransferase, Cancer Res. 44 (1984) 3806-3811.
25. 6-alkylguanine-DNA alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotides, Nucleic Acids Res. 16 (1988) 6779-6788.
26. F. Ali-Osman, Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione, Cancer Res. 49 (1989) 5258-5261.
27. R.S. Day, C. Ziolkowski, D. Scudiero, S. Meyer, A. Lubiniski, A. Girardi, S. Galoway, G. Bynum, Defective repair of alkylated DNA by human tumor and SV40 transformed human cell strains, Nature 288 (1980) 724-729.
28. 6-alkylguanine-DNA alkyltransferase activity in human lung tissue. Carcinogenesis 15, (1994) 1535-1539.
29. 6-Methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung and ovary, Cancer Res. 51 (1991) 4131-4134.
30. 6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors, Proc. Natl. Acad. Sci. USA 93 (1996) 6941-6946.
31. 6-alkylguanine-DNA alkytransferase gene in normal human liver tissues as revealed by in situ hybridization, Carcinogenesis 14 (1993) 737-741.
32. 6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues, Carcinogenesis 4 (1983) 1559-1564.
33. 6-alkylguanine-DNA-alkyltransferase in situ in ovarian and Hodgkin's tumors, Eur. J. Cancer 29 (A), (1993) 1306-1312.
34. 6-Methylguanine-DNA methyltransferase activity in human liver tumors, Carcinogenesis 12 (1991) 1313-1317.
35. 6-alkylguanine-DNA-alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors, Cancer Res. 51 (1991) 2092-2097.
36. 6-alkylguanine-DNA alkyltransferase repair activity in normal and neoplastic human tissues, Comp. Biochem. Physiol. B 101 (1992) 269-275.
37. 6-Methylguanine-DNA methyltransferase activity in breast and brain tumors. Int. J. Cancer 61, (1995) 321-326.
38. M. Belanich, M. Pastor, T. Randall, D. Guerra, J. Kibitel, L. Alas, B. Li, M. Citron, P. Wasserman, A. White, H. Eyre, K. Jaeckle, S. Shulman, D. Rector, M. Prados, S. Coons, W. Shapiro, D.B. Yarosh, Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine, Cancer. Res. 56 (1996) 783-788.
39. 6-methylguanine-DNA methyltransferase, J. Biol. Chem. 265 (1990) 9563-9569.
40. - human tumor cell lines containing the MGMT gene by polymerase chain reaction technique, Cancer Commun. 2 (1990) 13-20.
41. - human tumor cells. Cancer Res. 50, (1990) 7908-7911.
42. 6-methylguanine-DNA methyltransferase expression, Cancer Res. 53 (1993) 1731-1734.
43. 6-methylguanine DNA methyltansferase (MGMT) gene correlates with MGMT expression in human glioma cells, J. Biol. Chem. 269 (1994) 17228-17237.
44. 6-methylguanine-DNA methyltransferase, Mutat. Res. 293 (1993) 119-132.
45. 6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA. Mutat. Res. 255 (1991) 175-182.
46. 6-alkylguanine-DNA-alkyltransferase gene: molecular analysis of expression in rat liver, Carcinogenesis 12 (1991) 727-733.
47. 6-alkylguanine, Proc. Natl. Acad. Sci. USA 87 (1990) 686-690.
48. 6-methylguanine-DNA methyltransferase (MGMT) activity by antimessenger oligonucleotide sensitizes CHO/Mex+ transfected cells to mitozolomide, Carcinogenesis 17 (1996) 25-29.
49. C. Zlotogorski, L.C. Erickson, Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone, Carcinogenesis 4 (1983) 759-763.
50. W.J. Zeller, M.R. Berger, T. Henne, E. Weber, More than additive toxicity of the combination of 1-methyl-1-nitrosourea plus 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat, Cancer Res. 46 (1986) 1714-1716.
51. B.W. Futscher, K.C. Micetich, D.M. Barnes, R.I. Fisher, L.C. Erickson, Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells, Cancer Commun. 1 (1989) 65-73.
52. 6-alkylguanine DNA alkyltransferase by antitumor triazene compounds, J. Pharmacol. Exp. Ther. 279 (1996) 416-422.
53. B.W. Futscher, K.C. Micetich, D.M. Barnes, R.I. Fisher, L.C. Erickson, Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells, Cancer Commun. 1 (1989) 65-73.
54. 6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro, Cancer Res. 51 (1991) 1581-1585.
55. 6-alkylguanine-DNA alkyltransferase by streptozotocin in vivo, Cancer Res. 49 (1989) 3134-3138.
56. K.C. Micetich, B. Futscher, D. Koch, R.I. Fisher, L.C. Erickson, Phase I study of streptozotocin- and carmustine-sequenced administration in patients with advanced cancer, J. Natl. Cancer Inst. 84 (1992) 256-260.
57. 6-alkylguanine-DNA alkyltransferase-mediated carmustine resistance using streptozotocin: a phase I trial, Cancer Res. 52 (1992) 2456-2459.
58. 6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers, J. Clin. Oncol. 13 (1995) 2301-2308.
59. R.B. Mitchell, M.E. Dolan, L. Janisch, N.J. Vogelzang, M.J. Ratain, R.L. Schilsky, Sequential therapy with dacarbazine and carmustine: a phase I study, Cancer Chemother. Pharmacol. 34 (1994) 509-514.
60. 6-Alkylguanine-DNA alkyltransferase depletion and regeneration in human peripheral lymphocytes following dacarbazine and fotemustine, Cancer Res. 51 (1991) 619-623.
61. B. Gerard, S. Aamdal, S.M. Lee, S. Leyvraz, C. Lucas, M. D'Incalci, J.P. Bizzari, Activity and unexpected lung toxicity of the sequential administration of two alkylating agents -dacarbazine and fotemustine - in patients with melanoma, Eur. J. Cancer 29A (1993) 711-719.
62. 6-alkylguanine alkyltransferase, Clin. Cancer Res. 2 (1996) 1129-1134.
63. 6-alkylguanine-DNA transferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea, Cancer Chemother. Pharmacol. 32 (1993) 59-63.
64. 6-benzylguanine (BG), streptozotocin (STZ), and 1,3 bis(2-chloroethyl)-1-nitrosourea (BCNU), in vitro and in vivo, Biochem. Pharmacol. 48 (1994) 2127-2134.
65. P. Karran, Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair, Proc. Natl. Acad. Sci. USA 82 (1985) 5285-5289.
66. 6-alkylguanines, Cancer Res. 45 (1985) 6413-6417.
67. 6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents, Cancer Res. 46 (1986) 4500-4504.
68. 6-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents, Biochem. Biophys. Res. Commun. 132 (1985) 178-185.
69. 6-methlyguanine as a free base, Cancer Res. 46 (1986) 1663-1668.
70. 6-methylguanine in resistant but not in sensitive human melanoma cells, J. Cancer Res. Clin. Oncol. 113 (1987) 387-391.
71. 6-alkylguanine-DNA alkyltransferase, Cancer Res. 48 (1988) 1521-1527.
72. 6-methylguanine, Cancer Chemother. Pharmacol. 25 (1989) 103-108.
73. 6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro, Cancer Res. 53 (1993) 4281-4286.
74. 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents, Proc. Natl. Acad. Sci. USA 87 (1990) 5368-5372.
75. 6-methylguanine, Carcinogenesis 12 (1991) 2305-2309.
76. 6-benzylguanine, Biochemistry 32 (1993) 11998-12006.
77. 6-benzylguanine or N-methyl-N′-nitro-N-nitrosoguanidine, Carcinogenesis 12 (1991) 1679-1683.
78. 6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents, Cancer Res. 51 (1991) 3367-3372.
79. 6-benzylguanine in vitro and in vivo, Anticancer Res. 13 (1993) 801-806.
80. 6-benzylguanine in vitro, Carcinogenesis 14 (1993) 1057-1060.
81. 6-alkylguanine-DNA alkyltransferase, J. Cancer Res. Clin. Oncol. 121 (1995) 225-229.
82. 6-alkylguanine-DNA transferase correlates with potentiation of temozolomide and CCNU toxicity in human tumor cells, Br. J. Cancer 67 (1993) 1299-1302.
83. 6-benzylguanine and sensitization to BCNU, Cancer Chemother. Pharmacol. 35 (1995) 262-266.
84. 6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea resistant SF763 cells, Cancer Chemother. Parmacol. 32 (1993) 477-481.
85. 6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation, Cancer Res. 52 (1992) 1171-1175.
86. 6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, Cancer Commun. 2 (1990) 371-377.
87. H.S. Friedman, M.E. Dolan, R.C. Moschel, A.E. Pegg, G.M. Felker, J. Rich, D.D. Bigner, S.C. Schold, Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme, J. Natl. Cancer Inst. 84 (1992) 1926-1931.
88. 6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours, Acta. Neurochir. (Wien) 128 (1994) 13-20.
89. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea, Cancer Chemother. Pharmacol. 32 (1993) 471-476.
90. 6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), Biochem. Pharmacol. 46 (1993) 285-290.
91. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone, Biochem. Pharmacol. 45 (1993) 483-491.
92. 6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer, Cancer Chemother. Pharmacol. 32 (1993) 221-225.
93. 6-benzylguanine and its effectiveness against human brain tumor xenografts when administered in polyethylene glycol or cremophor-EL, Cancer Chemother. Pharmacol. 35 (1994) 121-126.
94. 6-benzylguanine in mice and dogs, Proc. Am. Assoc. Cancer Res. 35 (1994) 1953.
95. 6-benzylguanine (NSC-637037) and 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962) in mice, Proc. Am. Assoc. Cancer Res. 35 (1994) 1954.
96. 6-benzylguanine (NSC-637037) and BCNU (Carmustine, NSC-409962) in male and female Beagle dogs, Proc. Am. Assoc. Cancer Res. 35 (1994) 1952.
97. 6-alkylguanine-DNA alkyltransferase, Cancer Res. 54 (1994) 5123-5130.
98. 6-methylguanine-DNA methyltransferase inhibition in the nonhuman primate, Cancer Res. 55 (1995) 4606-4610.
99. 6-benzylguanine (BG) in patients with advanced cancer, Proc. Am. Assoc. Clin. Oncol. 15 (1996) 176.
100. 6-alkylguanine DNA alkyltransferase directed DNA repair, Proc. Am. Assoc. Clin. Oncol. 15 (1996) 177.
101. 6-benzylguanine in rats and its metabolism by rat liver microsomes, Drug Metab. Dispos. 23 (1995) 1394-1399.
102. 6-benzylguanine, Biochem. Pharmacol. 50 (1995) 1385-1389.
103. 6-arylmethylguanines, Biol. Pharm. Bull. 18 (1995) 424-430.
104. 6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells, Int. J. Cancer 58 (1994) 706-712.
105. 6-alkylguanine-DNA alkyltransferase, J. Med. Chem. 35 (1992) 4486-4491.
106. 6-alkylguanine-DNA alkyltransferase, J. Med. Chem. 37 (1994) 342-347.
107. 6-alkylguanine-DNA alkyltransferase, J. Med. Chem 38 (1995) 359-365.
108. 6-Substituted guanine derivatives, a process for their preparation and their use in treating tumour cells, International patent application WO94/29312, 1994.
109. 6-benzyl-N-acetylguanosine derivatives of chloroethylnitrosourea anti-tumor action in chloroethylnitrosourea-resistant human malignant melanocytes, J. Phamacol. Exp. Ther. 271 (1994) 1353-1358.
110. 6-substituted guanines), Anti-Cancer Drug Design 9 (1994) 401-408.
111. 6-alkylguanine-DNA alkyltransferase and N,N′-bis(2-chloroethyl)-N-nitrosourea, Biochem. Pharmacol. 50 (1995) 1141-1148.
112. 6-alkylguanine-DNA alkyltransferase, Drug Metab. Dispos. 24 (1996) 1205-1211.
113. 6-benzyl-2′-deoxyguanosine and BCNU, Cancer Res. 56 (1996) 2076-2081.
114. 6-benzyl-2′-deoxyguanosine in Sprague-Dawley rats, Chem. Res. Toxicol. 7 (1994) 762-769.
115. 6-benzylguanine, Biochem. J. 298 (1994) 231-235.
116. 6-benzylguanine, Cancer Res. 53 (1993) 4750-4753.
117. 6-benzylguanine, Cancer Res. 54 (1994) 6221-6227.
118. 6-benzylguanine, Cancer Res. 56 (1996) 5571-5575.
119. 6-methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay, Carcinogenesis 16 (1995) 2441-2445.
120. S. Devereux, T.G. Selassie, G.V. Hudson, B.V. Hudson, D.C. Linch, Leukemia complicating treatment for Hodgkins disease: the experience of the British National Lymphoma Investigation, Br. Med. J. 301 (1990) 1077-1080.
121. 6-Alkylguanine-DNA alkyltransferase activity in human myeloid cells, J. Clin. Invest. 76 (1985) 2106-2114.
122. 6-benzylguanine plus BCNU, Blood 88 (1996) 1649-1655.
123. 6-Benzylguanine increases the sensitvity of human primary bone marrow cells to the cytotoxic effects of temozolomide, Exp. Hematol. 23 (1995) 112-116.
124. J.A. Allay, L.L. Dumenco, O.N. Koc, L. Liu, S.L. Gerson, Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells, Blood 85 (1995) 3342-3351.
125. L.C. Harris, U.K. Marathi, C.C. Edwards, P.J. Houghton, E.F. Vanin, B.P. Sorrentino, T.P. Brent, Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against nitrosourea cytotoxicity, Proc. Am. Assoc. Cancer Res. 36 (1995) 419.
126. T. Moritz, W. Mackay, B.J. Glassner, D.A. Williams, L. Samson, Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo, Cancer Res. 55 (1995) 2608-2614.
127. 6-alkylguanine-DNA alkyltransferase, Blood 87 (1996) 1957-1961.
128. 6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents, Biochem. Pharmacol. 51 (1996) 1221-1228.
129. 6-benzylguanine plus BCNU, Proc. Natl. Acad. Sci. USA 93 (1996) 14088-14093.
130. 6-alkylguanine-DNA alkyltransferase, Gene Ther. 3 (1996) 868-877.
131. R. Maze, J.P. Carney, M.R. Kelley, B.J. Glassner, D.A. Williams, L. Samson, Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent, Proc. Natl. Acad. Sci. USA 93 (1996) 206-210.
132. 6-alkylguanine-DNA alkyltransferase, Science 259 (1993) 219-222.
133. 6-Methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis, Proc. Natl. Acad. Sci. USA 90 (1993) 6468.
134. 6-benzylguanine to killing by N,N′-bis(2-chloroethyl)-N-nitrosourea, Cancer Res. 7 (1996) 1578-1583.