Neutrophil migration during endotoxemia

Journal of Leukocyte Biology

Volumn 66, Issue 1, 1999, Pages 10-24

  Wagner, James G ^a   Roth, Robert A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Chemokine; Endotoxin; Inflammation; Lipopolysaccharide

Indexed keywords

CHEMOKINE; ENDOTOXIN; LIPOPOLYSACCHARIDE; PROTEINASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BURN; CELL FUNCTION; CELL MIGRATION; CYTOKINE PRODUCTION; ENDOTOXEMIA; HEMORRHAGIC SHOCK; HUMAN; HUMAN CELL; INFLAMMATION; INJURY; LEUKOCYTE ADHERENCE; LUNG DISEASE; LUNG INFECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW;

ANIMALIA;

EID: 0032990643     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.1.10     Document Type: Review

References (220)

1. Maderazo, E. G., Albano, S. D., Woronick, C. L., Drezner, A. D., Quercia, R. (1983) Polymorphonuclear leukocyte migration abnormalities and their significance in seriously traumatized patients. Ann. Surg. 198, 736-742.
2. Berger, D., Schmidt, U. M., Ott, S., Seidelmann, M., Martin, R., Beger, H. G. (1995) Incidence and pathophysiological relevance of postoperative pneumonia. FEMS Immunol. Med. Microbiol. 11, 285-290.
3. 2 integrins. J. Clin. Invest. 100, 1725-1733.
4. Simons, R. K., Maier, R. V., Lennard, E. S. (1987) Neutrophil function in a rat model of endotoxin-induced lung injury. Arch. Surg. 122, 197-203.
5. Grisham, M. B., Everse, J., Janssen, H. F. (1988) Endoloxemia and neutrophil activation in vivo. Am. J. Physiol. 254, H1017-H1022.
6. Hewett, J. A., Jean, P. A., Kunkel, S. L., Roth, R. A. (1993) Relationship between tumor necrosis factor-α and neutrophils in endotoxin-induced liver injury. Am. J. Physiol. 265, G1011-G1015.
7. Christou, N. V. (1996) Host defense mechanisms of surgical patients. Friend or foe? Arch. Surg. 131, 1136-1140.
8. Nelson, S., Chidiac, C., Bagby, G., Summer, W. R. (1990) Endotoxin-induced suppression of lung host defenses. J. Med. 21, 85-101.
9. Frevert, C. W., Warner, A. E., Kobzik, L. (1994) Defective pulmonary recruitment of neutrophils in a rat model of endotoxemia. Am. J. Respir. Cell Mol. Biol. 11, 716-723.
10. Hartilia, K. T., Langlois, L., Goldstein, I. M., Rosenbaum, J. T. (1985) Endotoxin-induced selective dysfunction of rabbit polymorphonuclear leukocytes in response to endogenous chemotactic factors. Infect. Immun. 50, 527-533.
11. Solomkin, J. S., Bass, R. C., Bjornson, H. S., Tindal, C. J., Babcock, G. F. (1994) Alterations of neutrophil responses to tumor necrosis factor and interleukin-8 following human endotoxemia. Infect. Immun. 62, 943-947.
12. Wagner, J. G., Harkema, J. R., Roth R. A. (1996) Temporal relationship between intravenous and intratracheal administrations of lipopolysaccharide (LPS) on pulmonary neutrophil (PMN) recruitment. Am. J. Respir. Crit. Care Med. 153, A837 (Abstract).
13. Duignan, J. P., Collins, P. B., Johnson, A. H., Bouchier-Hayes, D. (1986) The association of impaired neutrophil chemotaxis with postoperative surgical sepsis. Br. J. Surg. 73, 238-240.
14. White, J. C., Nelson, S., Winklestein, J. A., Booth, F. V., Jakab, G. J. (1986) Impairment of antibacterial defense mechanisms of the lung by extrapulmonary infection. J, Infect. Dis. 153, 202-208.
15. Hirano, S. (1996) Migratory responses of PMN after intraperitoneal and intratracheal administration of lipopolysaccharide. Am. J. Physiol. 270, L836-L845.
16. Mason, C. M., Dobard, E., Summer, W. R., Nelson, S. (1997) Intraportal lipopolysaccharide suppresses pulmonary antibacterial defense mechanisms. J. Infect. Dis. 176, 1293-1302.
17. Albelda, S. M., Smith, C. W., Ward, P. A. (1994) Adhesion molecules and inflammatory injury. FASEB J. 8, 504-512.
18. Malik, A. R., Lo, S. K. (1996) Vascular endothelial adhesion molecules and tissue inflammation. Pharmacol. Rev. 48, 213-229.
19. Ley, K. (1996) Molecular mechanisms of leukocyte recruitment in the inflammatory process. Cardiovasc. Res. 32, 733-742.
20. Crockett-Torabi, E. (1998) Selectins and mechanisms of signal transduction. J. Leukoc. Biol. 63, 1-14.
21. Vedanarayanan, V. V., Kaplan, B. S., Fong, J. S. C. (1987) Neutrophil function in an experimental model of hemolytic uremic syndrome. Pediatr. Res. 21, 252-256.
22. Territo, M. C., Golde, D. W. (1976) Granulocyte function in experimental human endotoxemia. Blood 47, 539-544.
23. Blackwood, R. A., Hartiala, K. T., Kwoh, E. E., Transue, A. T., Brower, R. C. (1996) Unidirectional heterologous receptor desensitization between both the fMLP and C5a receptor and the IL-8 receptor. J. Leukoc. Biol. 60, 88-93.
24. Kitayama, J., Carr, M. W., Roth, S. J., Buccola, J., Springer, T. A. (1997) Contrasting responses to multiple chemotactic stimuli in transendothelial migration. Heterologous desensitization in neutrophils and augmentation of migration in eosinophils. J. Immunol. 158, 2340-2349.
25. Meyrick, B. O., Brigham, K. L (1981) Acute effects of Escherichia coli endotoxin on the pulmonary microcirculation of anesthetized sheep. Structure-function relationships. Lab. Invest. 48, 458-470.
26. Haslett, C., Worthen, G. S., Giclas, P. C., Morrison, D. C., Henson, J. E., Henson, P. M. (1987) The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit. Am. Rev. Respir. Dis. 136, 9-18.
27. Zhang, P., Xie, M., Spitzer, J. A. (1994). Hepatic neutrophil sequestration in early sepsis: enhanced expression of adhesion molecules and phagocytic activity. Shock 2, 133-140.
28. - anion generation in in vivo Escherichia coli lipopolysaccharide and tumor necrosis factor-α treated rat neutrophils. Shock 2, 289-295.
29. Kuhns, D. B., Alvord, W. G., Gallin, J. I. (1995) Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans. J. Infect. Dis. 171, 145-152.
30. Holzer, K., Thiel, M., Moritz, S., Kreimeier, U., Messmer, K. (1996) Expression of adhesion molecules on circulating PMN during hyperdynamic endotoxemia. J. Appl. Physiol. 81, 341-348.
31. Pajkrt, D., Manten, A., van der Poll, T., Tiel-van Buul, M. M., Jansen, J., Wouter ten Cate, J., van Deventer, S. J. H. (1997) Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans. Blood 90, 1415-1424.
32. Morisaki, T., Goya, T., Toh, H., Nishihara, K., Torisu, M. (1991) The anti Mac-1 monoclonal antibody inhibits neutrophil sequestration in lung and liver in a septic murine model. Clin. Immunol. Immunopathol. 61, 365-375.
33. Doherty, D. E., Downey, G. P., Schwab, B., III, Elson, E., Worthen, G. S. (1994) Lipopolysaccharide-induced monocyte retention in the lung. Role of monocyte stiffness, actin assembly, and CD18-dependent adherence. J. Immunol. 153, 241-255.
34. Jaeschke, H. (1996) Chemokines, neutrophils, and inflammatory liver injury. Shock 6, 403-404.
35. Kubo, H., Doyle, N. A., Graham, L., Bhagwan, S., Quinlan, W. M., Doerschuk, C. M. (1999). L-and P-selectin and CD11/CD18 in intracapillary neutrophil sequestration in rabbit lungs. Am. J. Respir. Crit. Care Med. 159, 267-274.
36. Doerschuk, C. M. (1992) The role of CD18-mediated adhesion in neutrophil sequestration induced by infusion of activated plasma in rabbits. Am. J. Respir. Cell Mol. Biol. 7, 140-148.
37. Van Eeden, S. F., Kitagawa, Y., Klut, M. E., Lawrence, E., Hogg, J. C. (1997) Polymorphonuclear leukocytes released from the bone marrow preferentially sequester in lung microvessels. Microcirc. 4, 369-380.
38. Lawrence, E., Van Eeden, S., English, D., Hogg, J. C. (1996) Polymorphonuclear leukocyte (PMN) migration in streptococcal pneumonia: comparison of older PMN with those recently released from the marrow. Am. J. Respir. Cell Mol. Biol. 14, 217-224.
39. Klut, M. E., Whalen, B. A., Hogg, J. C. (1997) Activation-associated changes in blood and bone marrow neutrophils. J. Leukoc. Biol. 62, 186-194.
40. Kharazmi, A., Anderson, L. W., Baek, L., Valerius, N. H., Laub, M., Rasmussen, J. P. (1989) Endotoxemia and enhanced generation of oxygen radicals by neutrophils from patients undergoing cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 98, 381-385.
41. Cerasoli, F., Jr., McKenna, P. J., Rosalia, D. L., Albertine, K. H., Peters, S. P., Gee, M. H. (1990) Superoxide anion release from blood and bone marrow neutrophils is altered by endotoxemia. Circ. Res. 67, 154-165.
42. Blackwell, T. S., Blackwell, T. R., Holden, E. P., Christman, B. W., Christman, J. W. (1996) In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J. Immunol. 157, 1630-1637.
43. Holman, R. G., Maier, R. V. (1988) Superoxide production by neutrophils in a model of adult respiratory dirstress syndrome. Arch. Surg. 123, 1491-1495.
44. Mayer, A. M., Spitzer. J. A. (1991) Continuous infusion of Escherichia coli endotoxin in vivo primes in vitro superoxide anion release in rat polymorphonuclear leukocytes and Kupffer cells in a time-dependent manner. Infect. Immun. 59, 4590-4598.
45. Etheredge, E. E., Spitzer, J. A. (1993) Chronic endotoxemia reversibly alters respiratory burst activity of circulating neutrophils. J. Surg. Res. 55, 261-268.
46. Kajdacsy-Balla, A., Doi, E. M., Lerner, M. R., Bales, W. D., Archer, L. T., Wunder, P. R., Wilson, M. F., Brackett, D. J. (1996) Dose-response effect of in vivo administration of endotoxin on polymorphonuclear leukocytes oxidative burst. Shock 5, 357-361.
47. Michel, O., Nagy, A. M., Schroeven, M., Duchateau, J., Neve, J., Fondu, P., Sergysels, R. (1997) Dose-response relationship to inhaled endotoxin in normal subjects. Am. J. Respir. Crit. Care Med. 156, 1157-1164.
48. Thiel, M., Holzer, K., Kreimeier, U., Moritz, S., Peter, K., Messmer, K. (1997) Effects of adenosine on the functions of circulating polymorphonuclear leukocytes during hyperdynamic endotoxemia. Infect. Immun. 65, 2136-2144.
49. Fierro, I. M., Barja-Fidalgo, C., Cunha, F. Q., Ferreira, S. H. (1996) The involvement of nitric oxide in the anti-Candida albicans activity of rat neutrophils. Immunol. 89, 295-300.
50. Regel, G., Nerlich, M. L., Dwenger, A., Seidel, J., Schmidt, C., Sturm, J. A. (1987) Phagocytic function of polymorphonuclear leukocytes and the RES in endotoxemia. J. Surg. Res. 42, 74-84.
51. Spitzer, J. A., Zhang, P., Mayer, A. M. S. (1994) Functional characterization of peripheral circulating and liver recruited neutrophils in endotoxic rats. J. Leukoc. Biol. 56, 166-173.
52. Simms, H. H., D'Amico, R., Burchard, K. (1990) Untreated intraabdominal sepsis: Lack of synergism between polymorphonuclear leukocyte (PMN) complement receptors CR1/CR3 and IgG receptor FcRIII. J. Trauma 30, 1027-1031.
53. Bone, R. C., Balk, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., Sibbald, W. J. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101, 1644-1655.
54. Knaus, W. A., Sun, X., Nystrom, P. O., Wagner, D. P. (1992) Evaluation of definitions for sepsis. Chest 101, 1656-1662.
55. Dobke, M. K., Simoni, J., Ninneman, J. L., Garrett, J., Harnar, T. J. (1989) Endotoxemia after burn injury: effect of early excision on circulating endotoxin levels. J. Burn Care Rehab. 10, 107-111.
56. Ljunghusen, O., Lundahl, J., Nettelblad, H., Nilsson, B., Sjogren, F., Stendahl, O. (1996) Endotoxemia and complement activation after severe burn injuries - effects on leukocytes, soluble selectins, and inflammatory cytokines. Inflamm. 20, 229-241.
57. Kelly, J. L., O'Sullivan, C., O'Riordain, M., O'Riordain, D., Lyons, A., Doherty, J., Mannick, J. A., Rodrick, M. L. (1997) Is circulating endotoxin the trigger for the systemic inflammatory response syndrome seen after injury? Ann. Surg. 225, 530-543.
58. Fukushima, R., Alexander, J. W., Gianotti, L., Pyles, T., Ogle, C. K. (1995) Bacterial translocation-related mortality may be associated with neutrophil-mediated organ damage. Shock 3, 323-328.
59. Yao, Y. M., Lu, L. R., Yu, Y., Liang, H. P., Chen, J. S., Shi, Z. G., Zhou, B. T., Sheng, Z. Y. (1997) Influence of selective decontamination of the digestive tract on cell-mediated immune function and bacteria/endotoxin translocation in thermally injured rats. J. Trauma 42, 1073-1079.
60. Horton, J. W., White, J., Maass, D., Sanders, B. (1998) Arginine in burn injury improves cardiac performance and prevents bacterial translocation. J. Appl. Physiol. 84, 695-702.
61. Ono, Y., Kunii, O., Kobayashi, K., Kanegasaki, S. (1993) Evaluation of opsonophagocytic dysfunction in severely burned patients by luminol-dependent chemiluminescence. Microbiol. Immunol. 37, 563-571.
62. Hansbrough, J. F., Wilkstrom, T., Braide, M., Tenenhaus, M., Rennekampff, O. H., Kiessig, V, Zapata-Sirvent, R., Bjursten, L M. (1996) Effects of E-selectin and P-selectin blockade on neutrophil sequestration in tissues and neutrophil oxidative burst in burned rats. Crit. Care Med. 24, 1366-1372.
63. - generation after burn injury. Am. J. Physiol. 274, R476-R485.
64. Thomson, P. D., Till, G. O., Woolliscroft, J. O., Smith, D. J., Prasad, J. K. (1990) Superoxide dismutase prevents lipid peroxidation in burned patients. Burns 16, 406-408.
65. Xia, Z. F., Hollyoak, M., Barrow, R. E., He, F., Muller, M. J., Herndon, D. N. (1995) Superoxide dismutase and leupeptin prevent delayed reperfusion injury in the rat small intestine during burn shock. J. Burn Care Rehabil. 16, 111-117.
66. Bjornson, A. B., Somers, S. D., Knippenberg, R. W., Bjornson, H. S. (1992) Circulating factors contribute to elevation of intracellular cyclic3′,5'-adenosine monophosphate and depression of superoxide anion production in polymorphonuclear leukocytes following thermal injury. J. Leukoc. Biol. 52, 407-414.
67. Rosenthal, J., Thurman, G. W., Cusack, N., Peterson, V. M., Malech, H. L., Ambruso, D. R. (1996) Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox. Blood 88, 4321-4329.
68. Hasslen, S. R., Ahrenholz, D. H., Solem, L. D., Nelson, R. D. (1992) Actin polymerization contributes to neutrophil chemotactic dysfunction following thermal injury. J. Leukoc. Biol. 52, 495-500.
69. Vindenes, H. A., Bjerknes, R. (1997) Impaired actin polymerization and depolymerization in neutrophils from patients with thermal injury. Burns 23, 131-136.
70. Kim, Y., Goldstein, E., Lippert, W., Brofeldt, T., Donovan, R. (1989) Polymorphonuclear leukocyte motility in patients with severe burns. Burns 15, 93-97.
71. Bjornson, A. B., Somers, S. D. (1993) Down-regulation of chemotaxis of polymorphonuclear leukocytes following thermal injury involves two distinct mechanisms. J. Infect. Dis. 168, 120-127.
72. Hasslen, S. R., Nelson, R. D., Ahrenholz, D. H., Solem, L. D. (1993) Thermal injury, the inflammatory process, and wound dressing reduce human neutrophil chemotaxis to four chemoattractants. J. Burn Care Rehabil. 14, 303-309.
73. Mulligan, M. S., Till, G. O., Smith, C. W., Anderson, D. C., Miyasaka, M., Tamatani, T., Todd, R. F., III, Issekutz, T. B., Ward, P. A. (1994) Role of leukocyte adhesion molecules in lung and dermal vascular injury after thermal trauma of skin. Am. J. Pathol. 144, 1008-1015.
74. Stengle, J., Meyers, R., Pyle, J., Dries, D. J. (1996) Neutrophil recruitment after remote scald injury. J. Burn Care Rehabil. 17, 14-18.
75. Babcock, G. F., Alexander, J. W., Warden, G. D. (1990) Flow cytometric analysis of neutrophil subsets in thermally injured patients developing infection. Clin. Immunol. Immunopathol. 54, 117-125.
76. Rodeberg, D. A., Bass, R. C., Alexander, J. W., Warden, G. D., Babcock, G. F. (1997) Neutrophils from burn patients are unable to increase the expression of CD11b/CD18 in response to inflammatory stimuli. J. Leukoc. Biol. 61, 575-582.
77. Buttenschoen, K., Berger, D., Hiki, N., Strecker, W., Seidelmann, M., Beger, H. G. (1996) Plasma concentrations of endotoxin and antiendotoxin antibodies in patients with multiple injuries: a prospective clinical study. Eur. J. Surg. 162, 853-860.
78. Gebhard, F., Rosch, M., Helm, M., Strecker, W., Buttenschoen, K., Kinzl, L., Bock, K. H., Bruckner, U. B. (1997) Is the activity of soluble CD14 enhanced following major trauma? Arch. Surg. 132, 1116-1120.
79. Tanaka, H., Ogura, H., Yokota, J., Sugimoto, H., Yoshioka, T., Sugimoto, T. (1991) Acceleration of superoxide production from leukocytes in trauma patients. Ann. Surg. 214, 187-192.
80. Botha, A. J., Moore, F. A., Moore, E. E., Peterson, V. M., Silliman, C. C., Goode, A. W. (1996) Sequential systemic platelet-activating factor and interleukin-8 primes neutrophils in patients with trauma at risk of multiple organ failure. Br. J. Surg. 83, 1407-1412.
81. Krause, P. J., Woronick, C. L., Burke, G., Slover, N., Kosciol, C., Kelly, T., Spivack, B., Maderazo, E. G. (1994) Depressed neutrophil chemotaxis in children suffering blunt trauma. Pediatr. 93, 807-809.
82. Botha, A. J., Moore, F. A., Moore, E. E., Sauaia, A, Banerjee, A., Peterson, V. M. (1995) Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure. J. Trauma 39, 411-417.
83. Maekawa, K., Futami, S., Nishida, M., Terada, T., Inagawa, H., Suzuki, S., Ono, K. (1998) Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b. J. Trauma 44, 460-468.
84. Shijo, H., Iwabuchi, K., Hosoda, S., Watanabe, H., Nagaoka, I., Sakakibara, N. (1998) Evaluation of neutrophil functions after experimental abdominal surgical trauma. Inflamm. Res. 47, 67-74.
85. Girotti, M. J., Khan, N., McClellan B. A. (1991) Early measurement of systemic lipid peroxiodation products in plasma after blunt trauma patients. J. Trauma 31, 32-35.
86. Roumen, R. M., Frieling, J. T., van Tits, H. W., van der Vliet, J. A., Goris, R. J. (1993) Endotoxemia after major vascular operations. J. Vasc. Surg. 18, 853-857.
87. Berger, D., Bolke, E., Huegel, H., Seidelmann, M., Hannekum, A., Beger, H. G. (1995) New aspects concerning the regulation of the post-operative acute phase reaction during cardiac surgery. Clin. Chim. Acta 239, 121-130.
88. Foulds, S., Cheshire, M., Schachter, M., Wolfe, J. H., Mansfield, A. O. (1997) Endotoxin related early neutrophil activation is associated with outcome after thoracoabdominal aortic aneurysm repair. Br. J. Surg. 84, 172-177.
89. Brinkmann, A., Wolf, C. F., Berger, D., Kneitinger, E., Neumeister, B., Buchler, M., Radermacher, P., Seeling, W., Georgieff, M. (1996) Perioperative endotoxemia and bacterial translocation during major abdominal surgery: evidence for the protective effect of endogenous prostacyclin? Crit. Care Med. 24, 1293-1301.
90. Wakefield, C. H., Carey, P. D., Foulds, S., Monson, J. R., Guillou, P. J. (1993) Polymorphonuclear leukocyte activation: An early marker of the postsurgical sepsis response. Arch. Surg. 128, 390-395.
91. Barry, M. C., Wang, J. H., Kelly, C. J., Sheehan, S. J., Redmond, H. P., Bouchier-Hayes, D. J. (1997) Plasma factors augment neutrophil and endothelial cell activation during aortic surgery. Eur. J. Vasc. Endovasc. Surg. 13, 381-387.
92. Jensen, R. H., Storgaard, M., Vedelsdal, R., Obel, N. (1995) Impaired neutrophil chemotaxis after cardiac surgery. Scand. J. Thorac. Cardiovaac. Surg. 29, 115-118.
93. Deitch, E. A., Bridges, W., Berg, R., Specian, R. D., Granger, D. N. (1990) Hemorrhagic shock-induced bacterial translocation: the role of neutrophils and hydroxyl radicals. J. Trauma 30, 942-952.
94. Jiang, J., Bahrami, S., Leichtfried, G., Redl, H., Ohlinger, W., Schlag, G. (1995) Kinetics of endotoxin and tumor necrosis factor appearance in portal and systemic circulation after hemorrhagic shock in rats. Ann. Surg. 221, 100-106.
95. Barroso-Aranda, J., Chavez-Chavez, R. H., Schmid-Schonbein, G. W. (1992) Spontaneous neutrophil activation and the outcome of hemorrhagic shock in rabbits. Circ. Shock 36, 185-190.
96. Prasad, K., Kapoor, R., Kalra, J. (1992) Methionine in protection of hemorrhagic shock: role of oxygen free radicals and hypochlorous acid. Circ. Shock 36, 265-276.
97. Davis, J. M., Stevens, J. M., Peitzman, A., Corbett, W. A., Illner, H., Shires, G. T., III, Shires, G. T. (1983) Neutrophil migratory activity in severe hemorrhagic shock. Circ. Shock 10, 199-204.
98. Fink, M. P., Gardiner, M., MacVittie, T. J. (1985) Sublethal hemorrhage impairs the acute peritoneal response in rats. J. Trauma 25, 234-237.
99. Lindsay, T. F., Walker, P. M., Romaschin, A. (1995) Acute pulmonary injury in a model of ruptured abdominal aortic aneurysm. Vasc. Surg. 22, 1-8.
100. Hierholzer, C. Kalff, J. C., Omert, L., Tsukada, K., Loeffert, J. E., Watkins, S. C., Billiar, T. R., Tweardy, D. J. (1998) Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. Am. J. Physiol. 275, L611-L621.
101. Viryakosol, S., Kirkland, T. (1995) Knowledge of cellular receptors for bacterial endotoxins-1995. Clin. Infect. Dis. 21, S190-S195.
102. Holst, O., Ulmer, A. J., Brade, H.. Flad, H. D., Riestal, E. T. (1996) Biochemistry and cell biology of bacterial endotoxins. FEMS Immunol. Med. Microbiol. 16, 83-104.
103. Fenton, M. J., Golenbock, D. T. (1998) LPS-binding proteins and receptors. J. Leukoc. Biol. 64, 25-32.
104. Wang, P. Y., Kitchens, R. L., Munford, R. S. (1998) Phosphotidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide. J. Biol. Chem. 273, 24309-24313.
105. Devitt, A., Moffatt, O. D., Raykundalia, C., Capra, J. D., Simmons, D. L., Gregory, C. D (1998) Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 392, 505-509.
106. Delude, R. L., Fenton, M. J., Savedra, R., Perera, P. Y., Vogel, S. N., Thieringer, R., Golenbock, D. T. (1994) CD14-mediated translocation of nuclear factor-KB induced by lipopolysaccharide does not require tyrosine kinase activity. J. Biol. Chem. 269, 22253-22260.
107. Nick, J. A., Avdi, N. J., Gerwins, P., Johnson, G. L., Worthen, G. S. (1996) Activation of p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J. Immunol. 156, 4867-4875.
108. Sweet, M. J., Hume, D. A. (1996) Endotoxin signal transduction in macrophages. J. Leukoc. Biol. 60, 8-26.
109. Vasselon, T., Pironkova, R., Detmers, P. A. (1997) Sensitive responses of leukocytes to lipopolysaccharide require a protein distinct from CD14 at the cell surface. J. Immunol. 159, 498-505.
110. Yang, R. B., Mark, M. R., Gray, A., Huang, A., Xie, M. H., Zhang, M., Goddard, A., Wood, W. I., Gurney, A. L., Godowski, P. J. (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395, 284-288.
111. Zarewych, D. M., Kindzelskii, A. L., Todd, R. F., III, Petty, H. R. (1996) LPS induces CD14 association with complement receptor type 3, which is reversed by neutrophil adhesion. J. Immunol. 156, 430-433.
112. Su. G. L., Simmons, R. L., Wang, S. C. (1995) Lipopolysaccharide binding protein participation in cellular activation by LPS. Crit. Rev. Immunol. 15, 201-214.
113. Wurfel, M. M., Wright, S. D. (1997) Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid. J. Immunol. 158, 3925-3934.
114. Yu, B., Hailman, E., Wright, S. D. (1997) Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids. J. Clin. Invest. 99, 315-324.
115. Detmers, P. A., Thieblemont, N., Vasselon, T., Pironkova, R., Miller, D. S., Wright, S. D. (1996) Potential role of membrane internalization and vesicle fusion in adhesion of neutrophils in response to lipopolysaccharide and TNF. J. Immunol. 157, 5589-5596.
116. Borregaard, N., Cowland, J. B. (1997) Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89, 3503-3521.
117. Rodeberg, D. A., Morris, R. E., Babcock, G. F. (1997) Azurophilic granules of human neutrophils contain CD14. Infect. Immun. 65, 4747-1753.
118. Takai, N., Kataoka, M., Higuchi, Y., Matsuura, K., Yamamoto, S. (1997) Primary structure of rat CD14 and characteristics of rat CD14, cytokine, and NO synthase mRNA expression in mononuclear phagocyte system cells in response to LPS. J. Leukoc. Biol. 61, 736-744.
119. Flaherty, S. F., Golenbock, D. T., Milham, F. H., Ingalls, R. R. (1997) CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin. J. Surg. Res. 73, 85-89.
120. Ingalls, R. R., Arnaout, M. A., Delude, R. L., Flaherty, S., Savedra, R., Jr., Golenbock, D. T. (1998) The CD11/CD18 integrins: characterization of three novel LPS signaling receptors. Prog. Clin. Biol. Res. 397, 107-117.
121. Malhotra, R., Priest, R., Bird, M. I. (1996) Role for L-selectin in lipopolysaccharide-induced activation of neutrophils. Biochem. J. 320, 589-593.
122. Hard, T. H., Wang, D., Berkow, R. L (1990) Lipopolysaccharide modulates chemotactic peptide-induced actin polymerization in neutrophils. J. Leukoc. Biol. 47, 13-24.
123. Erzurum, S. C., Downey, G. P., Doherty, D. E., Schwabb, B., Elson, E. L, Worthen, G. S. (1992) Mechanisms of lipopolysaccharide-induced retention. J. Immunol. 149, 154-162.
124. Ehrengruber, M. U., Coates, T. D., Deranleau, D. A. (1995) Shape oscillations: a fundamental response of human neutrophils stimulated by chemotactic peptides? FEBS Lett. 359, 229-232.
125. Merry, C., Puri, P., Reen, D. J. (1996) Defective neutrophil actin polymersation and chemotaxis in stressed newborns. J. Pediatr. Surg. 31, 481-485.
126. - production and degranulation. J. Leukoc. Biol. 49, 236-244.
127. Bengtsson, T., Jaconi, M. E., Gustafson, M., Magnusson, K. E., Theler, J. M., Lew, D. P., Stendahl, O. (1993) Actin dynamics in human neutrophils during adhesion and phagocytosis is controlled by changes in intracellular free calcium. Eur. J. Cell Biol. 62, 49-58.
128. Wonderling, R. S., Ghaffar, A., Meyer, E. P. (1996) Lipopolysaccharide-induced suppression of phagocytosis: effects on the phagocytic machinery. Immunopharmacol. Immunotoxicol. 18, 267-289.
129. Lynn, W. A., Raetz, C. R. H., Qureshi, N., Golenbock, D. T. (1991) Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence for specific receptor-based response and inhibition by Lipid-A-based antagonists. J. Immunol. 147, 3072-3079.
130. Kishimoto, T. K., Kahn, J., Migaki, G., Mainolfi, E., Shirley, F., Ingraham, S. F., Rothlein, R. (1995) Regulation of L-selectin expression by membrane proximal proteolysis. Agents Actions Suppl. 47, 121-134.
131. Walchek, B., Kahn, J., Fisher, J. M., Wang, B. B., Fisk, R. S., Payan, D. G., Fehan, C., Betagari, R., Darlak, K., Spatola, A. F., Kishimoto, T. K. (1996) Neutrophil rolling altered by inhibition of L-selectin shedding in vitro. Nature 380, 720-723.
132. Fagny, C., Marchant, A., De Prez, E., Goldman, M., Deschodt-Lankman, M. (1995) Lipopolysaccharide induces upregulation of neutral endopeptidase 24.11 on human neutrophils: involvement of the CD14 receptor. Clin. Sci. 89, 83-89.
133. Detmers, P. A., Zhou, D., Powell, D. E. (1994) Different signaling pathways for CD18-mediated adhesion and Fc-mediated phagocytosis. J. Immunol. 153, 2137-2145.
134. Hailman, E., Vasselon, T., Kelley, M., Busse, L. A., Hu, M. C. T., Lichenstein, H. S., Detmers, P. A., Wright, S. D. (1996) Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14. J. Immunol. 156, 4384-4390.
135. Simms, H. H., D'Amico, R. (1995) Lipopolysaccharide induces intracytoplasmic migration of the polymorphonuclear leukocyte CD11b/CD18 receptor. Shock 3, 196-203.
136. Tiku, K., Tiku, M. L., Skosey, J. L. (1986) Interleukin-1 production by human polymorphonuclear neutrophils. J. Immunol. 136, 3677-3685.
137. Dubravec, D. B., Spriggs, D. R., Mannick, J. A., Rodick, M. L. (1990) Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor-α. Proc. Natl. Acad. Sci. USA. 87, 6758-6761.
138. Haziot, A., Tsuberi, B. Z., Goyert, S. M. (1993) Neutrophil CD14: biochemical properties and role in the secretion of tumor necrosis factor-α in response to lipopolysaccharide. J. Immunol. 150, 5556-5565.
139. Makristathis, A., Stauffer, F., Feistauer, M., Georgeopoulos, A. (1993) Bacteria induce release of platelet-activating factor (PAF) from polymorphonuclear granulocytes: possible role for PAF in pathogenesis of experimentally induced bacterial pneumonia. Infect. Immun. 61, 1996-2002.
140. 2, dexamethasone, and IL-4. J. Immunol. 151, 2166-2175.
141. Pouliot, M., Gilbert, C., Borgeat, P., Poubelle, P. E., Bourgoin, S., Creminon, C., Maclouf, J., McColl, S. R., Naccache, P. H. (1998) Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils. FASEB J. 12, 1109-1123.
142. 2) in human neutrophils. J. Clin. Invest. 92, 1467-1476.
143. Poelstra, K., Bakker, W. W., Klok, P. A., Hardonk, M. J., Meijer, D. K. F. (1997) A physiologic function for alkaline phosphatase: endotoxin detoxification. Lab. Invest. 76, 319-327.
144. 2+-dependent autoregulation of lipopolysaccharide-induced IL-8 receptor expression in human polymorphonuclear neutrophils. J. Immunol. 158, 1293-1301.
145. Khanderaker, M. H., Xu, L., Rahimpour, R., Mitchell, G., DeVries, M. E., Pickering, J. G., Singhal, S. K., Feldman, R. D., Kelvin, D. J. (1998) CXCR1 and CXCR2 are rapidly downmodulated by bacterial endotoxin through a unique agonist independent, tyrosine kinase dependent mechanism. J. Immunol. 161, 1930-1938.
146. Bignold, L. P., Rogers, S. D., Siaw, T. M., Bahnisch, J. (1991) Inhibition of chemotaxis of neutrophil leukocytes to interleukin-8 by endotoxins of various bacteria. Infect. Immun. 59, 4255-4258.
147. Kharazmi, A., Fomsgaard, A., Conrad, R. S., Galanos, C., Hoiby, N. (1991) Relationship between chemical composition and biological function of Pseudomonas aeruginosa lipopolysaccharide: Effect on human neutrophil chemotaxis and oxidative burst, J. Leukoc. Biol. 49, 15-20.
148. Derevianko, A., D'Amico, R., Graeber, T., Keeping, H., Simms, H. H. (1997) Endogenous PMN-derived reactive oxygen intermediates provide feedback regulation on respiratory burst signal transduction. J. Leukoc. Biol. 62, 268-276.
149. Lloyd, A. R., Biragyn, A., Johnston, J. A., Taub, D. D., Xu, L., Michiel, D., Sprenger, H., Oppenheim, J. J., Kelvin, D. J. (1995) Granulocyte-colony stimulating factor and lipopolysaccharide regulate the expression of interleukin 8 receptors on polymorphonuclear leukocytes. J. Biol. Chem. 270, 28188-28192.
150. Aida, Y., Pabst, M. J. (1990) Priming of neutrophils by lipopolysaccharide for enhanced release of superoxide. Requirement for plasma but not for tumor necrosis factor-α. J. Immunol. 145, 3017-3025.
151. Shapira, L., Champagne, C., Gordon, B., Amar, S., Van Dyke, T. E. (1995) Lipopolysaccharide priming of superoxide release by human neutrophils: role of membrane CD14 and serum LPS binding protein. Inflammation 19, 289-295.
152. Aida, Y., Kusamoto, K., Nakatomi, K., Takada, H., Pabst, M. J., Maeda, K. (1995) An analogue of lipid A and LPS from Rhodebacter sphaeroides inhibits neutrophil responses to LPS by blocking receptor recognition of LPS and by depleting LPS-binding protein in plasma. J. Leukoc. Biol. 58, 675-682.
153. Hughes, J. E., Stewart, J., Barclay, G. R., Govan, J. R. (1997) Priming of neutrophil respiratory burst activity by lipopolysaccharide from Burkholderia cepacia. Infect. Immun. 65, 4281-4287.
154. De Leo, F. R., Renee, J., McCormick, S., Kakamura, M., Apicella, M., Weiss, J. P., Nauseef, W. M. (1998) Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly. J. Clin. Invest. 101, 455-463.
155. Shappel, S. B., Toman, C., Anderson, D. C., Taylor, A. A., Entman, M. L., Smith, C. W. (1990) Mat-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J. Immunol. 144, 2702-2711.
156. Ottenello, L., Dapino, P., Scirocco, M., Barbera, P., Dallegri, F. (1994) Triggering of respiratory burst by tumor necrosis factor in neutrophils adherent to fibronectin. Evidence for a crucial role of CD18 glycoproteins. Agents Actions 41, 57-61.
157. Liles, W. C., Ledbetter, J. A., Waltersdorph, A. W., Klebanoff, S. J. (1995) Cross-linking of CD18 primes human neutrophils for activation of the respiratory burst in response to specific stimuli: Implications for adhesion-dependent physiological responses in neutrophils. J. Leukoc. Biol. 58, 690-697.
158. - production by neutrophil-endothelial cell interaction via CD11b: its modulation by tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide (LPS). Int. J. Hematol. 65, 49-59.
159. Fraticelli, A., Serrano, C. V., Jr., Bochner, B. S., Capogrossi, M. C., Zweier, J. L. (1996) Hydrogen peroxide and superoxide modulate leukocyte adhesion molecule expression and leukocyte endothelial adhesion. Biochim. Biophys. Acta 1310, 251-259.
160. Detmers, P. A., Zhou, D., Polizzi, E., Thieringer, R., Hanlon, W. A., Vaidya, S., Bansal, V. (1998) Role of stress-activated mitogen-activated protein kinase (p38) in β2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst. J. Immunol. 161, 1921-1929.
161. Anderson, R., Lukey, P., Van Rensburg, C., Dippenaar, U. (1986) Clofazimine-mediated regulation of human polymorphonuclear leukocyte migration by pro-oxidative inactivation of both leukoattractants and cellular migratory responsivness. Int. J. Immunopharmacol. 8, 605-620.
162. Bajaj, M. S., Kew, R. R., Webster, R. O., Hyers, T. M. (1992) Priming of human neutrophil functions by tumor necrosis factor: enhancement of superoxide anion generation, degranulation, and chemotaxis to chemoattractants C5a and
163. Ruchaud-Sparagano, M. H., Drost, E. M., Donnelly, S. C., Bird, M. I., Haslett, C., Dransfield, I. (1998) Potential pro-inflammatory effects of soluble E-selectin upon neutrophil function. Eur. J. Inflamm. 28, 80-89.
164. Ogino, T., Packer, L., Maguire, J. J. (1997) Neutrophil antioxidant capacity during the respiratory burst: loss of glutathione induced by chloramines. Free Rad. Biol. Med. 23, 445-452.
165. Fialkow, L., Chan, C. K., Rotin, D., Grinstein, S., Downey, G. P. (1994) Activation of the mitogen-activated protein kinase signaling pathways in neutrophils. Role of oxidants. J. Biol. Chem. 269, 31234-31242.
166. Smedegard, G., Cui, L., Hugli, T. E. (1989) Endotoxin-induced shock in rat. A role for C5a. Am. J. Pathol. 135, 489-497.
167. Witthaut, R., Farhood, A., Smith, C. W., Jaeschke, H. (1994) Complement and tumor necrosis factor-α contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo. J. Leukoc. Biol. 55, 105-111.
168. Tomhave, E. D., Richardson, R. M., Didsbury, J. R., Menard, L., Snyderman, R., Ali, H. (1994) Cross desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. J. Immunol. 153, 3267-3275.
169. Itoh, H., Cicala, C., Douglas, G. J., Page, C. P. (1996) Platelet accumulation induced by bacterial endotoxin in rats. Thromb. Res. 83, 405-419.
170. 2-integrin CD11b/CD18. Blood 88, 146-157.
171. Kaplan, K. (1986) In vitro platelet responses: α-granule secretion. In Platelet Responses and Metabolism, Vol. I (H. Holmsen, ed.) Boca Raton, FL: CRC Press, 145-162.
172. Su, S-B., Mukaida, N., Matsushima, K. (1996) Rapid secretion of intracellularly pre-stored interleukin-8 from rabbit platelets upon activation. J. Leukoc. Biol. 59, 420-426.
173. Aziz, K. A., Cawley, J. C., Treweeke, A. T., Zuzel, M. (1997) Sequential potentiation and inhibition of PMN reactivity by maximally stimulated platelets. J. Leukoc. Biol. 61, 322-328.
174. Oryu, M., Sakamoto, H., Ogawa, Y., Tanaka, S., Sakamoto, N. (1996) Effects of released products from platelets on neutrophilic adhesion to endothelial cells and nylon fibers. J. Leukoc. Biol. 60, 77-80.
175. Martich, G. D., Danner, R. L., Ceska, M., Suffredini, A. F. (1991) Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. J. Exp. Med. 173, 1021-1024.
176. Balazovich, K. J., Suchard, S. J., Remick, D. G., Boxer, L. A. (1996) Tumor necrosis factor-α and FMLP receptors are functionally linked during FMLP-stimulated activation of adherent human neutrophils. Blood 88, 690-696.
177. Otsuka, Y., Nagano, K., Nagano, K., Hori, K., Oh-Ishi, J-I., Hayashi, H., Watanabe, N., Niitsu, N. (1990) Inhibition of neutrophil migration by tumor necrosis factor. Ex vivo and in vivo studies in comparison with in vitro effect. J. Immunol. 145, 2639-2643.
178. Jersmann, H. P. A., Rathjen, D. A., Ferrante, A. (1998) Enhancement of lipopolysaccharide-induced neutrophil oxygen radical production by tumor necrosis factor alpha. Infect. Immun. 66, 1744-1747.
179. Suffredini, A. F., Reda, D., Banks, S. M., Tropea, M., Agosti, J. M., Miller, R. (1995) Effects of recombinant dimeric tumor necrosis factor receptor on human inflammatory responses following intravenous endotoxin administration. J. Immunol. 155, 5038-5045.
180. Ohira, H., Ueno, T., Torimura, T., Tanikawa, K., Kasukawa, R. (1995) leukocyte adhesion molecules in the liver and plasma cytokine levels in endotoxin-induced rat liver injury. Scand. J. Gastroenterol. 30, 1027-1035.
181. Fletcher, J. R., Collins, J. N., Graves, E. D., III, Luterman, A., Williams, M. D., Izenberg, S. D., Rodning, C. B. (1993) Tumor necrosis factor-induced mortality is reversed with cyclooxygenase inhibition. Ann. Surg. 217, 668-675.
182. Van der Poll, T., deWaal Malefyt, R., Coyle, S. M., Lowry, S. F. (1997) Anti-inflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurement of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J. Infect. Dis. 175, 118-122.
183. Moldawer, L. L. (1994) Biology of proinflammatory cytokines and their antagonists. Crit. Care Med. 22, S3-S7.
184. Mullen, P. G., Windsor, A. C., Walsh, C. J., Fowler, A. A., III, Sugarman, H. J. (1995) Tumor necrosis factor-α and interleukin-6 selectively regulate neutrophil function in vitro. J. Surg. Res. 58, 124-130.
185. Biffl, W. L., Moore, E. E., Moore, F. A., Barnett, C. C., Jr. (1996) Interleukin-6 delays neutrophil apoptosis via a mechanism involving platelet-activating factor. J. Trauma 40, 575-578.
186. Johnson, J. L., Moore, E. E., Tamura, D. Y., Zallen, G., Biffl, W. L., Silliman, C. C. (1998) Interleukin-6 augments neutrophil cytotoxic potential via selective enhancement of elastase release. J. Surg. Res. 76, 91-94.
187. Mathiak, G., Szewczyk, D., Abdullah, F., Ovadia, P., Rabinovici, R. (1997) Platelet-activating factor (PAF) in experimental and clinical sepsis. Shock 7, 391-404.
188. Rabinovici, R., Bugelski, P. J., Esser, K. M., Hillegass, L. M., Vernick, J., Feuerstein, G. (1993) ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rats. J. Appl. Physiol. 74, 1791-1802.
189. Filep, J. G., Delalandre, A., Fayette, Y., Foldes-Filep, E. (1997) Glucocorticoid receptor regulates expression of L-selectin and CD11/ CD18 on human neutrophils. Circulation 96, 295-301.
190. Luscinskas, F. W., Kiely, J. M., Ding, H., Obin, M. S., Hebert, C. A., Baker, J. B., Gimbrone, M. A., Jr. (1992) In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions. J. Immunol. 149, 2163-2171.
191. Chang, S-W. (1994) Endotoxin-induced pulmonary leukostasis in the rat: Role of platelet-activating factor and tumor necrosis factor. J. Lab. Clin. Med. 123, 6, 5-72.
192. Miotla, J. M., Jeffery, P. K., Hellewell, P. G. (1998) Platelet-activating factor plays a pivotal role in the induction of experimental lung injury. Am. J. Respir. Cell Mol. Biol. 18, 197-204.
193. Rose, C. E., Juliano, C. A., Tracey, D. E., Yoshimura, T., Fu, M. (1994) Role of interleukin-1 in endotoxin-induced lung injury in rat. Am. J. Respir. Cell Mol. Biol. 10, 214-221.
194. Zhang, P., Xie, M., Zagorski, J., Spitzer, J. A. (1995) Attenuation of hepatic sequestration by anti-CINC antibody in rat. Shock 4, 262-268.
195. Kunkel, S. L., Standiford, T., Kasahara, K., Stricter, R. M. (1991) Interleukin-8 (IL-8): the major neutrophil chemotactic factor in lung. Exp. Lung Res. 17, 17-23.
196. Rovai, L., Herschman, H. R., Smith, J. B. (1998) The murine neutrophil-chemoallractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia. J. Leukoc. Biol. 64, 494-502.
197. Hechtman, D. H., Cybulsky, M. I., Fuchs, H. J., Baker, J. B., Gimbrone, M. A., Jr. (1991) Intravascular IL-8: Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J. Immunol. 147, 883-892.
198. Roberts, P. J., Pizzey, A. R., Khwaja, A., Carver, J. E., Mire-Sluis, A. R., Linch, D. C. (1993) The effects of inlerleukin-8 on neutrophil fMetLeuPhe receptors, CD11b expression and metabolic activity, in comparison and combination with other cytokines. Br. J. Haematol. 84, 586-594.
199. Yong, K. L. (1996) Granulocyte colony stimulating factor (G-CSF) increases neutrophil migration across vascular endothelium independent of an effect on adhesion: comparison with granulocyte-macrophage colony-stimulating factor. Br. J. Haematol. 94, 40-47.
200. Cassatella, M. A., Meda, L., Bonora, S., Ceska, M., Constantin, G. (1993) Interleukin 10 (IL-10) inhibits release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharide. J. Exp. Med. 178, 2207-2211.
201. Wang, P., Wu, P., Anthes, J. C., Siegel, M. I., Egan, R. W., Billah, M. M. (1994) Interleukin-10 inhibits interleukin-8 production in human neutrophils. Blood 83, 2678-2683.
202. Bloemen, P. G., van den Tweel, M. C., Henricks, P. A., Engels, F., Kester, M. H., van de Loo, P. G., Blomjous, F. J., Nijkamp, F. P. (1997) Increased cAMP levels in stimulated neutrophils inhibit their adhesion to human bronchial epithelial cells. Am. J. Physiol. 272, L580-L587.
203. Laichalk, L. L., Danforth, J. M., Standiford, T. J. (1996) Interleukin-10 inhibits neutrophil phagocytic and bacterial activity. FEMS Immunol. Med. Microbiol. 15, 181-187.
204. Junger, W. G., Hoyt, D. B., Liu, F. C., Loomis, W. H., Coimbra, R. (1996) Immunosuppression after endotoxin shock: the result of multiple anti-inflammatory factors. J. Trauma 40, 702-709.
205. Ruetten, H., Thiemermann, C. (1997) Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. Br. J. Pharmacol. 122, 59-70.
206. 2 and selective EP agonists on chemotaxis of human neutrophils. Br. J. Pharmacol. 116, 2903-2908.
207. 2 on rat neutrophil aggregation. J. Leukoc. Biol. 60, 480-486.
208. Liu, S. F., Barnes, P. J., Evans, T. W. (1997) Time course and cellular localization of lipopolysaccharide-induced inducible nitric oxide synthase messenger RNA expression in the rat in vivo. Crit. Care Med. 25, 512-518.
209. Aono, K., Isobe, K., Kiuchi, K., Fan, Z., Ito, M., Takeuchi, A., Miyachi, M., Nakashima, I., Nimura, Y. (1997) In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines. J. Cell. Biochem. 65, 349-358.
210. Ruetten, H., Southan, G. J., Abate, A., Thiemermann, C. (1996) Attenuation of endotoxin-induced multiple organ dysfunction by 1-amino-2-hydroxy-guanidine, a potent inhibitor of inducible nitric oxide synthase. Br. J. Pharmacol. 118, 261-270.
211. Hock, C. E., Kingsley, Y., Yue, G., Wong, P. Y-K. (1997) Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia. Am. J. Physiol. 272, H834-H850.
212. G-monomethyl-L-arginine. Cardiovasc. Pharmacol. 20, S132-S134.
213. Kuo, H. P., Hwang, K. H., Lin, H. C., Wang, C. H., Lu, L. C. (1997) Effect of endogenous nitric oxide on tumor necrosis factor-α induced leukose-questration and IL-8 release in guinea-pigs airways in vivo. Br. J. Pharmacol. 122, 103-111.
214. Paya, D., Maupoil, V., Schott, C., Rochette, L., Stoclet, J-C. (1995) Temporal relationships between levels of circulating NO derivatives, vascular NO production and hyporeactivily to noradrenaline induced by endotoxin in rats. Cardiovasc. Res. 30, 952-959.
215. De Caterina, R., Libby, P., Peng, H. B., Thannickal, V. J., Rajavashisth, T. B., Gimbrone, M. A., Jr., Shin, W. S., Liao, J. K. (1995) Nitric oxide decreases cytokine-induced endothelial activation. J. Clin. Invest. 96, 60-68.
216. 2 integrin function by inhibiting membrane-associated cyclic GMP synthesis. J. Cell Physiol. 172, 12-24.
217. Pearson, J. M., Schultze, A. E., Jean, P. A., Roth, R. A. (1995) Platelet participation in liver injury from gram-negative bacterial lipopolysaccharide in the rat. Shock 4, 178-186.
218. Plescia, J., Altieri, D. C. (1996) Activation of Mac-1 (CD11b/CD18)-bound factor X by released cathepsin G defines an alternative pathway of leukocyte initiation of coagulation. Biochem. J. 319, 873-879.
219. Rozdzinski, E., Sandras, J., van der Flier, M., Young, M., Spellerberg, B., Bhattacharyya, C., Straub, J., Musso, G., Putney, S., Starzyk, R., Tuomanen, E. (1995) Inhibition of leukocyte-endothelial cell interactions and inflammation by peptides from a bacterial adhesin which mimic coagulation factor X. J. Clin. Invest. 95, 1078-1085.
220. Mesri, M., Plescia, J., Altieri, D. C. (1998) Dual regulation of ligand binding by CD11b I domain. Inhibition of intercellular adhesion and monocyte procoagulant activity by a factor X-derived peptide. J. Biol. Chem. 273, 744-748.