Frequency of the A1/A2 alleles of the D2 dopamine receptor (DRD2) gene in a British, Caucasian control group screened to exclude alcoholism and heavy drinking

Addiction Biology

Volumn 2, Issue 2, 1997, Pages 207-213

  Turner, Adrian ^a   Lawrence, Jacob ^a   Chen, Andrew Chih Hui ^a   Cook, Christopher ^a   Gurling, Hugh ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; DOPAMINE 2 RECEPTOR;

ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CAUCASIAN; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; UNITED KINGDOM;

EID: 0030895415     PISSN: 13556215     EISSN: None     Source Type: Journal    
DOI: 10.1080/13556219772750     Document Type: Article

References (39)

1. BLUM, K., NOBLE, E. P., SHERIDAN, P. J. et al. (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA, 263, 2055-2060.
2. BLUM, K., NOBLE, E. P., SHERIDAN, P. J. et al. (1991) Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism. Alcohol, 8, 409-416.
3. COMINGS, D. E., COMINGS, B. G., MUHLEMAN, D. et al. (1991) The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA, 266, 1793-1800.
4. NOBLE, E. P., SYNDULKO, K., FITCH, R. J. et al. (1994) D2 dopamine receptor TaqI A alleles in medically ill alcoholic and nonalcoholic patients. Alc Alcohol, 29, 729-744.
5. AMADEO, S., ABBAR, M., FOURCADE, M. L. et al. (1993) D2 dopamine receptor gene and alcoholism. J Psychiatr Res, 27, 173-179.
6. NEISWANGER, K., HILL, S. Y., KAPLAN, B. B. (1995) Association and linkage studies of the TaqI A1 allele at the dopamine D2 receptor gene in samples of female and male alcoholics. Am J Med Genet, 60, 267-271.
7. ARINAMI, T., ITOKAWA, M., KOMIYAMA, T. et al. (1993) Association between severity of alcoholism and the A1 allele of the dopamine D2 receptor gene TaqI A RFLP in Japanese. Biol Psychiatr, 33, 108-114.
8. PARSIAN, A., TODD, R. D., DEVOR, E. J. et al. (1991) Alcoholism and alleles of the human D2 dopamine receptor locus. Arch Gen Psychiatr, 48, 655-663.
9. BOLOS, A. M., DEAN, M., LUCAS-DERSE, S., RAMSBURG, M., BROWN, G. L., GOLDMAN, D. (1990) Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. JAMA, 264, 3156-3160.
10. GELERNTER, J., O'MALLEY, S., RISCH, N. et al. (1991) No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA, 266, 1801-1807.
11. SCHWAB, S., SOYKA, M., NIEDERECKER, M., ACKENHEIL, M., SCHERER, J., WILDENAUER, D. B. (1991) Allelic association of human dopamine D2-receptor DNA polymorphism ruled out in 45 alcoholics. Am J Hum Genet, 49 (Suppl):203.
12. COOK, B. L., WANG, Z. W., CROWE, R. R., HAUSER, R., FREIMER, M. (1992) Alcoholism and the D2 receptor gene. Alcohol Clin Exp Res, 16, 806-809.
13. GOLDMAN, D., DEAN, M., BROWN, G. L. et al. (1992) D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5-hydroxy-indoleacetic acid and 3-methoxy-4-hydroxy-phenylglycol in alcoholics in Finland and the United States. Acta Psychiatr Scand, 86, 351-357.
14. GOLDMAN, D., BROWN, G. L., ALBAUGH, B. et al. (1993) DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations. Alcohol Clin Exp Res, 17, 199-204.
15. KONO, Y., YONEDA, H., ISHIDA, T. et al. (1993) No association between the dopamine D2 receptor gene and alcoholism. Psychiatr Genet, 3, 172.
16. LU, R-B., CHANG, R-M., KO, H-C. et al. (1993) No association between alcoholism and the A1 at DRD2 gene in Han Chinese. Psychiatr Genet, 3, 172.
17. COMINGS, D. E., MUHLEMAN, D., AHN, C., GYSIN, R., FLANAGAN, S. D. (1994) The dopamine D2 receptor gene: a genetic risk factor in substance abuse. Drug Alcohol Depend, 34, 175-180.
18. GEIJER, T., NEIMAN, J., RYDBERG, U. et al. (1994) Dopamine D2-receptor gene polymorphisms in Scandinavian chronic alcoholics. Eur Arch Psychiatr Clin Neurosci, 244, 26-32.
19. AMADEO, S., FOURCADE, M. L., NICOLAS, L. et al. (1995) D2 receptor gene PCR polymorphism, alcohol and cannabis users. Psychiatr Genet, 5(Suppl. 1), S76.
20. CRUZ, C., PARSIAN, A., CAMARENA, B., PAEZ, F., DELA FUENTE, J. R., NICOLINI, H. (1995) Dopamine D2 receptor gene TaqI RFLPs and alcoholism in a Mexican population. Psychiatr Genet, 5(Suppl. 1), S49.
21. FINCKH, U., GIRALDO-VELASQUEZ, M., OTTO, G. et al. (1995) Phylogeny of the human dopamine D2 receptor gene (DRD2) and investigation of its association with alcoholism. Psychiatr Genet, 5(Suppl. 1), S77.
22. TURNER, E., EWING, J., SHILLING, P. et al. (1992) Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism. Biol Psychiatr, 31, 285-290.
23. CLONINGER, C. R. (1991) D2 Dopamine receptor gene is associated but not linked with alcoholism. JAMA, 266, 1833-1834.
24. GOLDMAN, D., BROWN, G. L., BOLOS, A. M., LUCAS-DERSE, S., DEAN, M. (1991) The dopamine D2 receptor gene and alcoholism (Letter). JAMA, 265, 2668.
25. NOBLE, E. P., BLUM, K. (1991) The dopamine D2 receptor gene and alcoholism (Letter). JAMA, 265, 2667.
26. SMITH, S. S., GORELICK, D. A., O'HARA, B. F., UHL, G. R. (1991) The dopamine D2 receptor gene and alcoholism (Letter). JAMA, 265, 2667-2668.
27. GELERNTER, J., GOLDMAN, D., RISCH, N. (1993) The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal. JAMA, 269, 1673-1677.
28. NOBLE, E. P. (1993) The D2 dopamine receptor gene: a review of association studies in alcoholism. Behav Genet, 23, 119-129.
29. SPITZER, R. L., ENDICOTT, J. (1978) Schedule for affective disorders and schizophrenia - lifetime version, 3rd edn. New York: New York State Psychiatric Institute.
30. STOCKWELL, T., HODGSON, R., EDWARDS, G., TAYLOR, C., RANKIN, H. (1979) The development of a questionnaire to measure severity of alcohol dependence. Br J Addict, 74, 79-87.
31. EDWARDS, G., GROSS, M. (1976) Alcohol Dependence: provisional description of a clinical syndrome. Br Med J, 1, 1058-1061.
32. SPITZER, R. L., ENDICOTT, J., ROBINS, E. (1978) Research diagnostic criteria. Arch Gen Psychiatr, 35, 773-782.
33. ROYAL COLLEGE OF PSYCHIATRISTS. (1986) Alcohol: our favourite drug. London: Tavistock.
34. GRANDY, D. K., ZHANG, Y., CIVELLI, O. (1993) PCR detection of the TaqI A RFLP at the DRD2 locus. Hum Mol Genet, 2, 2197.
35. BARR, C. L., KIDD, K. K. (1993) Population frequencies of the Al allele at the dopamine D2 receptor locus. Biol Psychiatr, 34, 204-209.
36. KOPEC, A. C. (1970) The distribution of the blood groups in the United Kingdom. Oxford: Oxford University Press.
37. MOURANT, A. E., KOPEC, A. C., DOMANIEWSKA-SOBCZAK, K. (1976) The distribution of the human blood groups and other polymorphisms. Oxford: Oxford University Press.
38. FALK, C. T., RUBINSTEIN, P. (1987) Haplotype relative risks: an easy and reliable way to construct a proper control sample for risk calculations. Ann Hum Genet, 51, 227-233.
39. COOK, C. C. H., PALSSON, G., TURNER, A. et al. (1996) A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism. Br J Psychiatr, 169, 243-248.