DRD2 allele frequencies and linkage disequilibria, including the - 141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects

Genomics

Volumn 51, Issue 1, 1998, Pages 21-26

  Gelernter, J ^a,d   Kranzler, H ^b   Cubells, J F ^a   Ichinose, H ^c   Nagatsu, T ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR;

ARTICLE; ASIAN; CAUCASIAN; DNA POLYMORPHISM; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; HAPLOTYPE; HUMAN; NEGRO; NORMAL HUMAN; PRIORITY JOURNAL; PROMOTER REGION; RACE DIFFERENCE;

EID: 0032127155     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1998.5264     Document Type: Article

References (30)

1. Arinami T., Gao M., Hamaguchi H., Toru M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum. Mol. Genet. 6:1997;577-582.
2. Berrettini W. H., Persico A. M. Dopamine D2 receptor gene polymorphisms and vulnerability to substance abuse in African Americans. Biol. Psychiatry. 40:1996;144-147.
3. Blum K., Noble E. P., Sheridan P. J., Montgomery A., Ritchie T., Jagadeeswaran P., Nogami H., Briggs A. H., Cohn J. B. Allelic association of human dopamine D2 receptor gene in alcoholism. J. Am. Med. Assoc. 263:1990;2055-2060.
4. Blum K., Sheridan P. J., Chen T. C. H., Wood R. C., Braverman E. R., Cull J. G., Comings D. E. The dopamine D2 receptor gene locus in reward deficiency syndrome: Meta-analyses. Handbook of Psychiatric Genetics. 1997;CRC Press, Boca Raton. p. 407-432.
5. Castiglione C. M., Deinard A. S., Speed W. C., Sirugo G., Rosenbaum H. C., Zhang Y., Grandy D. K., Grigorenko E. L., Bonne-Tamir B., Pakstis A. J., Kidd J.R., Kidd K. K. Evolution of haplotypes at the DRD2 locus. Am. J. Hum. Genet. 57:1995;1445-1456.
6. 2. Pharmacogenetics. 6:1996a;73-79.
7. Comings D. E., Muhleman D., Gysin R. Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication. Biol. Psychiatry. 40:1996b;368-372.
8. Cubells J. F., Kobayashi K., Nagatsu T., Kidd K. K., Kidd J. R., Calafell F., Kranzler H., Ichinose H., Gelernter J. Population genetics of a functional variant of the dopamine β-hydroxylase gene (DBH). Am. J. Med. Genet. 74:1997;374-379.
9. 2. Genomics. 14:1992;1010-1018.
10. 2. J. Am. Med. Assoc. 271:1994;204-208.
11. Gelernter J., O'Malley S., Risch N., Kranzler H., Krystal J., Merikangas K., Kennedy J., Kidd K. K. No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. J. Am. Med. Assoc. 266:1991;1801-1807.
12. 2, Biol. Psychiatry.
13. Gelernter J., Goldman D., Risch N. The A1 allele at the D2 dopamine receptor gene and alcoholism: A reappraisal. J. Am. Med. Assoc. 269:1993;1673-1677.
14. Gelernter J., Kranzler H., Coccaro E., Siever L., New A., Mulgrew C. D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. Am. J. Hum. Genet. 61:1997;1144-1152.
15. Grandy D. K., Zhang Y., Civelli O. PCR detection of the TaqA RFLP at the DRD2 locus. Hum. Mol. Genet. 2:1993;2197.
16. Grandy D. K., Litt M., Allen L., Bunzow J. R., Marchionni M., Makam H., Reed L., Magenis R. E., Civelli O. The human dopamine D2 receptor gene is located in chromosome 11 at q22-q23 and identifies a Taq I polymorphism. Am. J. Hum. Genet. 45:1989;778-785.
17. Hauge X. Y., Grandy D. K., Eubanks J. H., Evans G. A., Civelli O., Litt M. Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics. 10:1991;527-530.
18. Kidd K. K., Pakstis A. J., Castiglione C. M., Kidd J. R., Speed W. C., Goldman D., Knowler W. C., Lu R-B., Bonne-Tamir B. DRD2 haplotypes containing theTaq. Alc. Clin. Exp. Res. 20:1996;697-705.
19. Laruelle M., Gelernter J., Innis R. D2 receptors binding potential is not affected byTaq. Mol. Psychiatry. 3:1998;261-265.
20. Lewontin R. C. On measures of gametic disequilibrium. Genetics. 120:1988;849-852.
21. Long J. C., Williams R. C., Urbanek M. An E-M algorithm and testing strategy for multiple-locus haplotypes. Am. J. Hum. Genet. 56:1995;799-810.
22. O'Hara B. F., Smith S. S., Bird G., Persico A. M., Suarez B. K., Cutting G. R., Uhl G. R. Dopamine D2 receptor RFLPs haplotypes and their association with substance use in black and Caucasian research volunteers. Hum. Hered. 43:1993;209-218.
23. Parsian A., Fisher L., O'Malley K. L., Todd R. D. A newTaq. Nucleic Acids Res. 19:1991;6977.
24. Peterson A. C., Di Rienzo A., Lehesjoki A-E., de la Chapelle A., Slatkin M., Freimer N. B. The distribution of linkage disequilibrium over anonymous genome regions. Hum. Mol. Genet. 4:1995;887-894.
25. Sarkar G., Kapelner S., Grandy D. K., Marchionni M., Civelli O., Sobell J., Heston L., Sommer S. S. Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics. 11:1991;8-14.
26. 22. Neuropsychopharmacology. 8:1993;137-143.
27. Sham P. C., Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 59:1995;97-105.
28. Spiess E. B. Genes in Populations. 1989;Wiley, New York.
29. Suarez B. K., Parsian A., Hampe C. L., Todd R. D., Reich T., Cloninger C. R. Linkage disequilibria at the D2 dopamine receptor locus (DRD2) in alcoholics and controls. Genomics. 19:1994;12-20.
30. Uhl G., Blum K., Noble E., Smith S. Substance abuse vulnerability and D2 receptor genes. Trends Neurosci. 16:1993;83-88.