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note
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2 (3 × 2 mL). If the ninhydrin test showed a positive result, then the procedure was repeated. The resin was used directly for the next step of the reaction. Final products were cleaved from the resin with TFA/water (95:5).
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2O). Gradient: 10% to 100% B within 15 min. UV monitoring at 220 nm.
-
2O). Gradient: 10% to 100% B within 15 min. UV monitoring at 220 nm.
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-
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43
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85037505145
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LC-MS was performed on a Hewlett-Packard 1100 system
-
LC-MS was performed on a Hewlett-Packard 1100 system.
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-
-
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44
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85037503066
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6, 300 MHz), δ 11.1, 11.2 (s, 1H), 7.0-7.6 (m, 4H), 4.7-4.9 (m, 1H), 4.1-4.3 (m, 1H), 3.2-3.4 (m, 2H), 2.9-3.2 (m, 2H)
-
6, 300 MHz), δ 11.1, 11.2 (s, 1H), 7.0-7.6 (m, 4H), 4.7-4.9 (m, 1H), 4.1-4.3 (m, 1H), 3.2-3.4 (m, 2H), 2.9-3.2 (m, 2H).
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-
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45
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85037503028
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1H NMR analysis of the THBC core 7j indicated that the diastereomeric ratio is approximately 1:1 in the mixture
-
1H NMR analysis of the THBC core 7j indicated that the diastereomeric ratio is approximately 1:1 in the mixture.
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46
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0033992319
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