Synthesis of N-protected α-amino aldehydes from their morpholine amide derivatives

Tetrahedron Letters

Volumn 41, Issue 1, 2000, Pages 37-40

  Douat, Céline ^a   Heitz, Annie ^a   Martinez, Jean ^a   Fehrentz, Jean Alain ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AMIDE; LITHIUM DERIVATIVE; MORPHOLINE;

ARTICLE; CHEMICAL MODIFICATION; REDUCTION; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0033992319     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01818-3     Document Type: Article

References (11)

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10. 4 aqueous solution (5 mL) and extracted with diethyl ether. After classical work-up, 675 mg of a white solid were obtained (yield 91%) which were purified by column chromatography on silica gel with ethyl acetate/hexane (v/v) containing 0.1% pyridine as eluent. Pure material (510 mg) was obtained (68%).
11. Fehrentz, J. A.; Pothion, C.; Califano, J. C.; Loffet, A.; Martinez, J. Tetrahedron Lett. 1994, 35, 9031-9034.