Synthesis of highly epimerizable N-protected α-amino aldehydes of high enantiomeric excess

Tetrahedron Letters

Volumn 41, Issue 9, 2000, Pages 1359-1362

  Myers, Andrew G ^a   Zhong, Boyu ^a   Movassaghi, Mohammad ^a   Kung, Daniel W ^a   Lanman, Brian A ^a   Kwon, Soojin ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOALCOHOL; AMINOALDEHYDE; OXIDIZING AGENT;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENANTIOMER; REACTION ANALYSIS; SYNTHESIS;

EID: 0034716554     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)02293-5     Document Type: Article

References (26)

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18. 2-Iodoxybenzoic acid was prepared by oxidation of 2-iodobenzoic acid according to a recently reported procedure: Frigerio, M.; Santagostino, M.; Sputore, S. J. Org. Chem. 1999, 64, 4537-4538. 2-Iodoxybenzoic acid was transformed to the Dess-Martin periodinane following the Ireland protocol: Ireland, R. E.; Liu, L. J. Org. Chem. 1993, 58, 2899.
19. 2-Iodoxybenzoic acid was prepared by oxidation of 2-iodobenzoic acid according to a recently reported procedure: Frigerio, M.; Santagostino, M.; Sputore, S. J. Org. Chem. 1999, 64, 4537-4538. 2-Iodoxybenzoic acid was transformed to the Dess-Martin periodinane following the Ireland protocol: Ireland, R. E.; Liu, L. J. Org. Chem. 1993, 58, 2899.
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26. R(N-Fmoc-(R)-phenylglycinol)=24.5 min) established an ee of 99%.