Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1)

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 10, 1999, Pages 1423-1428

  McComsey, David F ^a   Hawkins, Michael J ^a   Andrade Gordon, Patricia ^a   Addo, Michael F ^a   Oksenberg, Donna ^b   Maryanoff, Bruce E ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRIAZOLE; ANISOLE; CINNAMIC ACID; HETEROCYCLIC COMPOUND; RESIN; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TRIFLUOROACETIC ACID; TRIPEPTIDE;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

CELL LINE; HETEROCYCLIC COMPOUNDS; HUMANS; OLIGOPEPTIDES; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 0033577762     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00197-3     Document Type: Article

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31. Abbreviations not defined earlier in this paper: Fmoc = 9-fluorenylmethoxycarbonyl; BOP-Cl = N,N'- bis(2-oxo-3-oxazolidinyl)phosphinyl chloride; DMAP = 4-(dimethylamino)pyridine; TFA = trifluoroacetic acid; PMC = 2,2,5,7,8-pentamethylchroman-6-sulfonyl; Har = homoarginine.