Age changes in signal transduction and gene expression

Mechanisms of Ageing and Development

Volumn 98, Issue 3, 1997, Pages 231-238

  Roth, George S ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; DNA SYNTHESIS; DOPAMINERGIC SYSTEM; GENE EXPRESSION; LIVER CELL; MOTOR PERFORMANCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AGING; ANIMALS; DNA; DOPAMINE; GENE EXPRESSION; LIVER; SIGNAL TRANSDUCTION;

EID: 0030656377     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(97)00110-3     Document Type: Article

References (35)

1. G.S. Roth, Mechanisms of altered hormone-neurotransmitter action during aging: from receptors to calcium mobilization, Ann. Rev. Geront. Geriatrics 10 (1990) 132-136.
2. A. Miyamoto, G.S. Roth, Changes in transmembrane signaling mechanisms during aging - cellular and molecular aspects, in: A. Maciera-Coelho (Ed.), Molecular Basis of Aging, CRC Press, Boca Raton, FL, 1995, pp. 293-306.
3. G.S. Roth, J.A. Joseph, Cellular and molecular mechanisms of impaired dopaminergic function during aging, Ann. NY Acad. Sci. 719 (1994) 129-135.
4. Z. Hall, An Introduction to Molecular Neurobiology, Sinauer Associates, Sunderland, MA, 1992.
5. J.A. Joseph, R.E. Berger, B.T. Engel, G.S. Roth, Age related changes in the nigrostriatum: A behavioral and biochemical analysis, J. Gerontol. 33 (1978) 643-649.
6. H. Lai, D.M. Bowden, A. Horita, Age-related decreases in dopamine receptors in the caudate nucleus and putamen of the rhesus monkey (Macaca mulatta), Neurobiol. Aging 8 (1987) 4549.
7. D.K. Ingram, R.G. Cutler, R. Weindruch, D.M. Renquist, M.J. Knapka, M. April, C.T. Belcher, M.A. Clark, C.D. Hatcheran, B.M. Marriott, G.S. Roth, Dietary restriction and aging; the initiation of a primate study, J. Gerontol. 45 (1990) B148-163.
8. J.M. Henry, G.S. Roth, Effect of aging on recovery of striatal dopamine receptors following N-ethoxycarbony-2-ethoxy-1,2-dihydroquinoline (EEDQ) blockade, Life Sci. 35 (1984) 899-904.
9. S.E. Leff, R. Gariano, I. Creese, Dopamine receptor turnover rates in rat striatum are age-dependent, Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 3910-3914.
10. 2 dopamine receptor cDNA, Nature 336 (1988) 783-787.
11. 2 receptors during aging is partially due to decreased levels of mRNA, Brain Res. 545 (1991) 355-357.
12. 2 receptor mRNA subtypes in rat brain, Neurochem. Int. 20 (1992) 495-585.
13. 2 receptor mRNA's in brain areas of two rat strains, Mol. Brain Res. 12 (1992) 357-359.
14. 2 receptor mRNA isoforms during aging in Fischer 344 rats, Neurosci. Lett. 154 (1993) 163-167.
15. 4 receptor mRNA levels in rat brain and pituitary during aging, Neurobiol. Aging 15 (1994) 713-719.
16. 2-dopamine receptor mRNA is selectively reduced during aging, Mol. Brain Res. 17 (1993) 160-162.
17. O. Bugiani, S. Salvarini, F. Perdelli, G.L. Mancardi, A. Leonardi, Nerve cell loss with aging in the putamen, Eur. Neurol. 17 (1978) 286-291.
18. 2-receptor containing neurons in the rat striatum, Brain Res. 298 (1989) 299-307.
19. 2 receptor mRNA-containing neurons: A quantitative nonradioactive in situ hybridization study, J. Neurosci. 15 (1995) 1735-1740.
20. L. Zhang, G. Kokkonen, G.S. Roth, Identification of neuronal programmed cell death in situ in the striatum of normal adult rat brain and its relationship to neuronal death during aging, Brain Res. 677 (1995) 177-179.
21. R.E. Ellis, J. Yuan, H.R. Horwitz, Mechanisms and functions of cell death, Ann. Res. Cell. Biol. 7 (1991) 663-698.
22. 2 dopamine receptor gene promoter. Mol. Brain Res. 44 (1997) 113-124.
23. 2 receptor cDNA into rat striatum, Mol. Brain Res. 34 (1995) 315-320.
24. D. Danon, M.A. Kowatch, G.S. Roth, Promotion of wound repair in old mice by local injection of macrophages, Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 2018-2020.
25. 14C into the DNA of regenerating rat liver, Cancer Res. 24 (1964) 509-512.
26. P. Duarte, M. Pascal, Thymectomy at weaning. An accelerated aging model for the mouse immune system, Mech. Ageing Dev. 59 (1991) 275-289.
27. L.H. Hartwell, M.B. Kastin, Cell cycle control and cancer, Science 266 (1994) 1821-1828.
28. L. Hayflick, The limited in vivo lifetime of human diploid call strains, Exp. Cell Res. 37 (1965) 614-636.
29. R.C. Adelman, G. Stein, G.S. Roth, D. Englander, Age-related regulation of mammalian DNA synthesis and cell proliferation in vivo, Mech. Ageing Dev. 1 (1972) 49-59.
30. A. Ishigami, G. S. Roth, Age-related changes in DNA synthesis stimulated by epinephrine and isoproterenol in primary cultured rat hepatocytes, J. Cell. Physiol. 158 (1994) 231-236.
31. A. Ishigami, T.D. Reed, G.S. Roth, Effect of aging on EGF stimulated DNA synthesis and EGF receptor levels in primary cultured rat hepatocytes, Biophys. Res. Comm. 196 (1993) 181-186.
32. N. Sawada, T. Ishikawa, Reduction of potential for replicative but not unscheduled DNA synthesis in hepatocytes isolated from aged as compared to young rats, Cancer Res. 48 (1988) 1618-1622.
33. A. Noda, Y. Ning, S.E. Venable, O.M. Perevia-Smith, J.R. Smith, Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen, Exp. Cell Res. 211 (1994) 90-98.
34. S. Kitano, S. Venable, J.R. Smith, T.D. Reed, G.S. Roth, Effect of aging on regulation of sdi-1 in rat hepatocytes, Biochem. Biophys. Res. Comm. 225 (1996) 122-127.
35. Y. Liu, K.Z. Guyton, M. Gorospe, Q. Xu, G.C. Kokkonen, Y.D. Mock, G.S. Roth, NJ. Holbrook, Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes, J. Biol. Chem. 271 (1996) 3604-3607.