Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging

Annals of the New York Academy of Sciences

Volumn 854, Issue , 1998, Pages 171-181

  Kovalenko, Sergey A ^a   Kopsidas, George ^a   Kelso, Joanne ^a   Rosenfeldt, Franklin ^b   Linnane, Anthony W ^a  

^a EPWORTH HOSPITAL   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ADOLESCENT; ADULT; AGED; AGING; BIOENERGY; CELL LEVEL; CHILD; CONFERENCE PAPER; ELECTRON TRANSPORT; GENE DELETION; GENE DUPLICATION; GENE REARRANGEMENT; HEART MUSCLE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; MITOCHONDRION; SKELETAL MUSCLE; TISSUE DEGENERATION; TISSUE DISTRIBUTION; TISSUE LEVEL;

EID: 0032408418     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb09900.x     Document Type: Conference Paper

References (42)

1. HARMAN, D. 1956. Ageing: A theory based on free radical and radiation chemistry. J. Gerontol. 11: 298-300.
2. RICHTER, C., J.-W. PARK & B.N. AMES. 1988. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 85: 6465-6467.
3. TAPPEL, A.L. 1973. Lipid peroxidation damage to cell components. Fed. Proc. 32(8): 1870-1874.
4. FRAGA, C.G. & A.L. TAPPEL. 1988. Damage to DNA concurrent with lipid peroxidation in rat liver slices. Biochem. J. 252(3): 893-896.
5. OLIVER, C.N., B.W. AHN E.J. MOERMAN, S. GOLDSTEIN & E.R. STADTMAN. 1987. Age-related changes in oxidized proteins. J. Biol. Chem. 262(12): 5488-5491.
6. STADTMAN, E.R., P.E. STARKE-REED, C.N. OLIVER, J.M. CARNEY & R.A. FLOYD. 1992. Protein modification in aging. Exs 62: 64-72.
7. SOHAL, R.S., I. SVENSSON, B.H. SOHAL & U.T. BRUNK. 1989. Superoxide anion radical production in different animal species. Mech. Ageing Dev. 49(2): 129-135.
8. KU, H.H., U.T. BRUNK & R.S. SOHAL. 1993. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radical Biol. Med. 15(6): 621-627.
9. CHEN, Q., A. FISCHER, J.D. REAGAN, L.J. YAN & B.N. AMES. 1995. Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc. Natl. Acad. Sci. USA 92(10): 4337-4341.
10. HAYAKAWA, M., K. HATTORI, S. SUGIYAMA & T. OZAWA. 1992. Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem. Biophys. Res. Commun. 189(2): 979-985.
11. SHIGENAGA, M.K., T.M. HAGEN & B.N. AMES. 1994. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA 91(23): 10771-10778.
12. NOHL, H. & D. HEGNER. 1978. Do mitochondria produce oxygen radicals in vivo? Eur. J. Biochem. 82(2): 563-567.
13. LINDAHL T. 1993. Instability and decay of primary structure of DNA. Nature 362: 709-715.
14. NOHL H. 1993. Involvement of free radicals in aging: A consequence or cause of senescence. Br. Med. Bull. 49(3): 653-667.
15. LINNANE, A.W., G. KOPSIDAS, J. KELSO & S.A. KOVALENKO. 1997. Occurrence of age-associated multiple mtDNA rearrangements in human skeletal muscle. FASEB J. 11(9): A1450.
16. KOPSIDAS, G., S.A. KOVALENKO, J. KELSO & A.W. LINNANE. 1998. An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle. Mutat. Res. In press.
17. LINNANE, A.W., A. BAUMER, R.J. MAXWELL, H. PRESTON, C.F. ZHANG & S. MARZUKI. 1990. Mitochondrial gene mutation: The ageing process and degenerative diseases. Biochem. Int. 22(6): 1067-1076.
18. TANAKA M., H. INO, K. OHNO, T. OHBAYASHI, S. IKEBE, T. SANO, T. ICHIKI, M. KOBAYASHI, Y. WADA & T. OZAWA. 1991. Mitochondrial DNA mutations in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Biochem. Biophys. Res. Commun. 174(2): 861-868.
19. YEN, T.C., J.H. SU, K.L. KING & Y.H. WEI. 1991. Ageing-associated 5 kb deletion in human liver mitochondrial DNA. Biochem. Biophys. Res. Commun. 178(1): 124-131.
20. OZAWA, T. 1995. Mechanism of somatic mitochondrial DNA mutations associated with age and diseases. Biochim. Bioph. Acta 1271(1): 177-189.
21. KADENBACH, B., C. MUNSCHER, V. FRANK, J. MULLER-HOCKER & J. NAPIWOTZKI. 1995. Human aging is associated with stochastic somatic mutations of mitochondrial DNA. Mutat. Res. 338 (1-6): 161-172.
22. LIU, V.W.S., C. ZHANG, A.W. LINNANE & P. NAGLEY. 1997. Quantitative allele-specific PCR: Demonstration of age-associated accumulation in human tissue of the A to G mutation at nucleotide 3243 in mitochondrial DNA. Hum. Mutation 9(3): 265-271.
23. SIMONETTA, S., X. CHEN, S. DI MAURO & E.A. SCHON. 1992. Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR. Biochem. Biophis. Acta 1180: 113-122.
24. OZAWA, T., M. TANAKA, S. IKEBE, K. OHNO, T. KONDO & Y. MIZUNO. 1990. Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis. Biochem. Biophys. Res. Commun. 172(2): 483-489.
25. LINNANE, A.W., C. ZHANG, A. BAUMER & P. NAGLEY. 1992. Mitochondrial DNA mutation and the ageing process: Bioenergy and pharmacological intervention. Mutat. Res. 275(3-6): 195-208.
26. ZHANG C., A. BAUMER, R.J. MAXWELL, A.W. LINNANE & P. NAGLEY. 1992. Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett. 297: 4-8.
27. NAGLEY, P., C. ZHANG, R.D. MARTINUS, F. VAILLANT & A.W. LINNANE. 1993. Mitochondrial DNA mutation and human aging: molecular biology, bioenergetics and redox therapy. In Mitochondrial DNA in Human Pathology. S. DiMauro, D. Wallace, Eds.: 137-157. Raven Press. New York.
28. HAYAKAWA, M., K. KATSUMATA, M. YONEDA, M. TANAKA, S. SUGIYAMA & T. OZAWA. 1995. Mitochondrial DNA minicircles, lacking replication origins, exist in the cardiac muscle of a young normal subject. Biochem. Biophys. Res. Commun. 215(3): 952-960.
29. BAUMER, A., C. ZHANG, A.W. LINNANE & P. NAGLEY. 1994. Age-related human mtDNA deletions: A heterogeneous set of deletions arising at a single pair of directly repeated sequences. Am. J. Hum. Genet. 54(4): 618-630.
30. LEE, C.M., S.S. CHUNG, J.M. KACZKOWSKI, R. WEINDRUCH & J.M. AIKEN. 1993. Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J. Gerontol. 48: B201-B205.
31. KOVALENKO, S.A., G. KOPSIDAS, J. KELSO & A.W. LINNANE. 1997. Deltoid human muscle mtDNA is extensively rearranged in old age subjects. Biochem. Biophys. Res. Commun. 232: 147-152.
32. MELOV, S., D. HINERFELD, L. ESPOSITO & D.C. WALLACE. 1997. Multi-organ characterisation of mitochondrial genomic rearrangements in ad libidum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acids Res. 25(5): 974-982.
33. ZHANG, C., M. BILLS, A. QUIGLEY, R.J. MAXWELL, A.W. LINNANE & P. NAGLEY. 1997. Varied prevalence of age-associated mitochondrial DNA deletions in different species and tissues: A comparison between human and rat. Biochem. Biophys. Res. Commun. 230(3): 630-635.
34. HAGEN, T.M., D.L. YOWE, J.C. BARTHOLOMEW, C.M. WEHR, K.L. DO, J.Y. PARK & B.N. AMES. 1997. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase. Proc. Natl. Acad. Sci. USA 94(7): 3064-3069.
35. TROUNCE, I., E. BYRNE & S. MARZUKI. 1989. Decline in skeletal muscle mitochondrial respiratory chain function: Possible factor in ageing. Lancet ii: 637-639.
36. MÜLLER-HÖCKER, J. 1989. Cytochrome-c-oxidase deficient cardimyocytes in the human heart. An age related phenomenon. Am. J. Pathol. 134: 1167-1173.
37. CORRAL D.M., J.M. SHOFFNER, , M.T. LOTT & D.C. WALLACE. 1992. Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat. Res. 275(3-6): 169-180.
38. LINNANE, A.W., S. MARZUKI, T. OZAWA & M. TANAKA. 1989. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1: 642-645.
39. CORRAL-DEBRINSKI, M., T. HORTON, M.T. LOTT, J.M. SHOFFNER, M.F. BEAL & D.C. WALLACE. 1992. Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age. Nat. Genet. 2: 324-329.
40. SOONG, N.W., D.R. HINTON, G. CORTOPASSI & N. ARNHEIM. 1992. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat. Genet. 2(4): 318-323.
41. RICHTER, C. 1992. Reactive oxygen and DNA damage in mitochondria. Mutat. Res. 275(3-6): 249-255.
42. BECKMAN K.B. & B.N. AMES. 1996. Detection and quantification of oxidative adducts of mitochondrial DNA. Methods Enzymol. 264: 442-453.