Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor

Molecular Endocrinology

Volumn 14, Issue 12, 2000, Pages 2024-2039

  Schaufele, Fred ^a   Chang, Ching yi ^b   Liu, Weiqun ^a   Baxter, John D ^a   Nordeen, Steven K ^c   Wan, Yihong ^c   Day, Richard N ^d   McDonnell, Donald P ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d NATIONAL SCIENCE FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; DOXYCYCLINE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FULVESTRANT; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GREEN FLUORESCENT PROTEIN; LIGAND; OLIGONUCLEOTIDE; PEPTIDE; RALOXIFENE; TAMOXIFEN;

AMINO ACID SEQUENCE; ARTICLE; DISSOCIATION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

EID: 0034534579     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.12.0572     Document Type: Article

References (50)

1. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
2. The molecular biology of thyroid hormone action
3. Tripartite steroid hormone receptor pharmacology: Interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones
4. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
5. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities
6. Structure and specificity of nuclear receptor-coactivator interactions
7. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
8. Identification of a conserved region required for hormone dei pendent transcriptional activation by steroid hormone receptors
9. Hormone-dependent coactivator binding to a hydropho)-bic cleft on nuclear receptors
10. Molecular basis of agonism and antagonism in the oestrogen receptor
11. Estrogen receptor activation function 1 works by binding p160 coactivator proteins
12. Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: Discovery of peptide antagonists of estrogen receptors α and β
13. Peptide antagonists of the human estrogen receptor
14. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β
15. Therapeutic potential of selective modulators of nuclear receptor action
16. Tamoxifen, raloxifene, and the prevention of breast cancer
17. Therapeutic potential of selective estrogen receptor modulators
18. The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. Multiple outcomes of raloxifene evaluation
19. Relationship between estrogen levels, use of hormone replacement therapy, and breast cancer
20. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
21. AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors
22. Direct visualization of the human estrogen receptor α reveals a role for ligand in the nuclear distribution of the receptor
23. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera
24. Sub-cellular localization of mineralocorticoid receptors in living cells: Effects of receptor agonists and antagonists
25. Differential localization and activity of the A- and B-forms of the human progesterone receptor using green fluorescent protein chimeras
26. Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus
27. Subnuclear trafficking of estrogen receptor-a and steroid receptor coactivator-1
28. Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer
29. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor
30. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
31. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
32. GRIP1, a transcriptional coactivator for the AF-2 trans-activation domain of steroid, thyroid, retinoid, and vitamin D receptors
33. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
34. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
35. Visualization of Pit-1 transcription factor interactions in the living cell nucleus by fluorescence resonance energy transfer microscopy
36. Activities in Pit-1 determine whether receptor interacting protein 140 activates or inhibits Pit-1/nuclear receptor transcriptional synergy
37. Tamoxifen activation of the estrogen receptor/AP-1 pathway: Potential origin for the cell-specific estrogen-like effects of antiestrogens
38. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
39. Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor
40. The dose dependence of glucocorticoid-inducible gene expression resuits from changes in the number of transcriptionally active templates
41. Tamoxifen in the treatment of breast cancer
42. Risks and benefits of tamoxifen therapy
43. Transcriptional augmentation: Modulation of gene expression by scaffold/matrix-attached regions (S/MAR elements)
44. Interrelationships of nuclear structure and transcriptional control: Functional consequences of being in the right place at the right time
45. Nuclear structure, gene expression and development
46. Half a century of "the nuclear matrix."
47. Selection of estrogen receptor β and thyroid hormone receptor β-specific co-activator-mimetic peptides using recombinant peptide libraries
48. CCAAT/enhancer-binding protein α activation of the rat growth hormone promoter in pituitary progenitor GHFT1-T5 cells
49. Transcriptional activation by tetracyclines in mammalian cells
50. Regulation of estrogen receptor activation of the prolactin enhancer/promoter by antagonistic activation function-2-interacting proteins