Differential localization and activity of the A- and B-forms of the human progesterone receptor using green fluorescent protein chimeras

Molecular Endocrinology

Volumn 13, Issue 3, 1999, Pages 366-375

  Lim, Carol S ^a   Baumann, Christopher T ^a   Htun, Han ^a,b   Xian, Wenjuan ^a   Irie, Masako ^a   Smith, Catharine L ^a   Hager, Gordon L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MIFEPRISTONE; PROGESTERONE RECEPTOR;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN LOCALIZATION; REPORTER GENE;

ANIMALIA; EUKARYOTA; MAMMALIA; MAMMARY TUMOR VIRUS; MOUSE MAMMARY TUMOR VIRUS; TUMOR VIRUS;

EID: 0032941272     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.3.0247     Document Type: Article

References (25)

1. 1. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP 1993 Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 7:1244-1255
2. 2. Graham JD, Yeates C, Balleine RL, Harvey SS, Milliken JS, Bilous AM, Clarke CL 1996 Progesterone receptor A and B protein expression in human breast cancer. J Steroid Biochem Mol Biol 56:93-98
3. 3. Htun H, Barsony J, Renyi I, Gould DJ, Hager GL 1996 Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Proc Natl Acad Sci USA 93:4845-4850
4. 4. Zhu X, Hanover JA, Hager GL, Cheng S-Y 1998 Hormone-induced translocation of thyroid hormone receptors in living cells visualized using a receptor-green fluorescent protein chimera. J Biol Chem 273: 27058-27063
5. 5. Guiochon-Mantel A, Lescop P, Christin-Maitre S, Loosfelt H, Perrot-Applanat M, Milgrom E 1991 Nucleocytoplasmic shuttling of the progesterone receptor. EMBO J 10:3851-3859
6. 6. Vegeto E, Allan GF, Schrader WT, Tsai MJ, McDonnell DP, O'Malley BW 1992 The mechanism of RU486 antagonism is dependent on the conformation of the carboxyterminal tail of the human progesterone receptor. Cell 69:703-713
7. 7. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P 1990 Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9:1603-1614
8. 8. Guiochon-Mantel A, Loosfelt H, Lescop P, Sar S, Atger M, Perrot-Applanat M, Milgrom E 1989 Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers. Cell 57:1147-1154
9. 9. Edwards DP, Altmann M, DeMarzo A, Zhang Y, Weigel NL, Beck CA 1995 Progesterone receptor and the mechanism of action of progesterone antagonists. J Steroid Biochem Mol Biol 53:449-458
10. 10. Takimoto GS, Hovland AR, Tasset DM, Melville MY, Tung L, Horwitz KB 1996 Role of phosphorylation on DNA binding and transcriptional functions of human progesterone receptors. J Biol Chem 271:13308-13316
11. 11. Tetel MJ, Jung S, Carbajo P, Ladtkow T, Skafar DF, Edwards DP 1997 Hinge and amino-terminal sequences contribute to solution dimerization of human progesterone receptor. Mol Endocrinol 11:1114-1128
12. 12. Gorski J, Toft D, Shyamala G, Smith D, Notides A 1968 Hormone receptors: studies on the interaction of estrogen with the uterus. Recent Prog Horm Res 24:45-80:45-80
13. 13. King WJ, Greene GL 1984 Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells. Nature 307:745-747
14. 14. Jans DA 1995 The regulation of protein transport to the nucleus by phosphorylation. Biochem J 311:705-716
15. 15. Johnson J, Corbisier R, Stensgard B, Toft D 1996 The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes. J Steroid Biochem Mol Biol 56:31-37
16. 16. DeFranco DB 1997 Subnuclear trafficking of steroid receptors. Biochem Soc Trans 25:592-597
17. 17. Yang J, Liu J, DeFranco DB 1997 Subnuclear trafficking of glucocorticoid receptors in vitro: chromatin recycling and nuclear export. J Cell Biol 137:523-538
18. 18. Lefebvre P, Berard DS, Cordingley MG, Hager GL 1991 Two regions of the mouse mammary tumor virus LTR regulate the activity of its promoter in mammary cell lines. Mol Cell Biol 11:2529-2537
19. 19. Giordano T, Howard TH, Coleman J, Sakamoto K, Howard BH 1991 Isolation of a population of transiently transfected quiescent and senescent cells by magnetic affinity cell sorting. Exp Cell Res 192:193-197
20. 20. Archer TK, Cordingley MG, Marsaud V, Richard-Foy H, Hager GL 1989 Steroid transactivation at a promoter organized in a specifically-positioned array of nucleosomes. In: Gustafsson JA, Eriksson H, Carlstedt-Duke J (eds) Proceedings: Second International CBT Symposium on the Steroid/Thyroid Receptor Family and Gene Regulation. Birkhauser Verlag AG, Berlin, pp 221-238
21. 21. Ostrowski MC, Richard-Foy H, Wolford RG, Berard DS, Hager GL 1983 Glucocorticoid regulation of transcription at an amplified, episomal promoter. Mol Cell Biol 3:2045-2057
22. 22. Smith CL, Hager GL 1997 Transcriptional regulation of mammalian genes in vivo: a tale of two templates. J Biol Chem 272:27493-27496
23. 23. Smith CL, Htun H, Wolford RG, Hager GL 1997 Differential activity of progesterone and glucocorticoid receptors on mouse mammary tumor virus templates differing in chromatin structure. J Biol Chem 272:14227-14235
24. 24. Kitabayashi I, Eckner R, Arany Z, Chiu R, Gachelin G, Livingston DM, Yokoyama KK 1995 Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells. EMBO J 14:3496-3509
25. 25. Tyagi RK, Amazit L, Lescop P, Milgrom E, Guiochon-Mantel A 1998 Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate. Mol Endocrinol 12:1684-1695