Novel strategies for therapeutic design in molecular oncology using gene expression profiles

Current Opinion in Molecular Therapeutics

Volumn 2, Issue 6, 2000, Pages 682-690

  Ricci, M S ^a   El Deiry, W S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

DNA microarrays; Gene expression profiling; Molecular oncology

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTINEOPLASTIC AGENT; APC PROTEIN; ARF PROTEIN; BCR ABL PROTEIN; BETA CATENIN; BRCA1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; CYTOKINE; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLYCOPROTEIN P; INTERFERON; INTERLEUKIN 2; MYC PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN CDC25A; PROTEIN KINASE; PROTEIN P53; PROTEIN PRB; PROTEIN RHOC; RAF PROTEIN; RAS PROTEIN; SURVIVIN; TELOMERASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CANCER; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER RESEARCH; CARCINOGENESIS; CELL GROWTH; DNA DAMAGE; DNA MICROARRAY; DRUG DESIGN; GENE EXPRESSION; GENE SEQUENCE; GENOME; ONCOGENE; ONCOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; GENE EXPRESSION PROFILING; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENES; PHENOTYPE;

EID: 0034520338     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Human genome: Rival genome sequencers celebrate a milestone together
2. Expression profiling: DNA arrays in many guises
3. Expression profiling using cDNA microarrays
4. Analysis of gene expression in single live neurons
5. Laser capture microdissection
6. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays
7. In vivo gene expression profile analysis of human breast cancer progression
8. Serial analysis of gene expression
9. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
10. WAF1, a potential mediator of p53 tumor suppression
11. Use of a cDNA microarray to analyse gene expression patterns in human cancer
12. Gene expression data analysis
13. Cluster analysis and display of genome-wide expression patterns
14. A genome-wide survey of Ras transformation targets
15. Gene expression profiles in normal and cancer cells
16. Expression analysis with oligonucleotide microarrays reveals that Myc regulates genes involved in growth, cell cycle, signaling, and adhesion
17. Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations
18. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
19. Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the H-ras transgene or nullizygosity for p53
20. Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage
21. Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line
22. Bex-deficient mice with lymphoid hyperplasia and male germ cell death
23. Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
24. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
25. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
26. Identificafion of fractalkine, a CX3C-type chemokine, as a direct target of p53
27. Identification of a novel mouse p53 target gene DDA3
28. Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis
29. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses
30. Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis
31. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
32. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
33. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
34. Biology of the adenomatous polyposis coil tumor suppressor
35. Identification of c-Myc as a target of the APC pathway
36. PPARδ is an APC-regulated target of non-steroidal anti-inflammatory drugs
37. Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray
38. CDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene
39. Bcr-Abl tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia
40. Selection of successive tumour lines for metastasis
41. Genomic analysis of metastasis reveals an essential role for RhoC
42. Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
43. Genes expressed in human tumor endothelium
44. Dissecting the regulatory circuitry of a eukaryotic genome
45. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles
46. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
47. Signaling networks - Do all roads lead to the same genes?
48. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
49. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
50. How diagnosis with microarrays can help cancer patients
51. Molecular portraits of human breast tumours
52. Molecular classification of cutaneous malignant melanoma by gene expression profiling
53. Biomedical discovery with DNA arrays
54. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
55. Drug target validation and identification of secondary drug target effects using DNA microarrays
56. Functional discovery via a compendium of expression profiles
57. Systematic variation in gene expression patterns in human cancer cell lines
58. A gene expression database for the molecular pharmacology of cancer
59. A public database for gene expression in human cancers
60. Genome-wide analysis of DNA copy-number changes using cDNA microarrays
61. Detection of gene amplification by genomic hybridization to cDNA microarrays