Pathogenesis of colorectal cancer

Digestive and Liver Disease

Volumn 32, Issue 9, 2000, Pages 807-821

  de Leon, M P ^a   Percesepe, A ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Cancer; Colon; FAP; Gene; HNPCC; IBD; Rectum; Tumour

Indexed keywords

DNA;

CANCER GROWTH; CANCER PREVENTION; CELL DIFFERENTIATION; CELL GROWTH; COLON CARCINOGENESIS; COLON MUCOSA; COLON POLYPOSIS; COLORECTAL CANCER; COLORECTAL TUMOR; CONTROLLED STUDY; DNA SEQUENCE; DNA STRUCTURE; ENTERITIS; FAMILIAL CANCER; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC DAMAGE; GENETIC REGULATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; INTESTINE TUMOR; MALIGNANT TRANSFORMATION; MICROSATELLITE INSTABILITY; MOLECULAR BIOLOGY; MOLECULAR CLONING; MUTATOR GENE; ONCOGENE; PATHOGENESIS; PHENOTYPE; REGULATORY MECHANISM; REVIEW; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; TREATMENT PLANNING; TUMOR PROMOTION; TUMOR SUPPRESSOR GENE;

COLORECTAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MOLECULAR BIOLOGY; PRECANCEROUS CONDITIONS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

EID: 0034490007     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (141)

1. The cause of colorectal cancer
2. Temporal patterns in colorectal cancer incidence, survival, and mortality from 1950 through 1990
3. An update of HNPCC (Lynch syndrome)
4. Molecular genetics of polyposis and hereditary colorectal cancer
5. Colorectal cancer: Molecules and populations
6. Screening sigmoidoscopy and colorectal cancer mortality
7. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis
8. Genetic basis of tumour development
9. Molecular epidemiology of human cancer: Contribution of mutation spectra studies of tumor suppressor genes
10. Genetic basis of hereditary nonpolyposis colorectal carcinoma (HNPCC)
11. Genetic alterations during colorectal-tumor development
12. Carcinoma and adenomatous polyps of the colon and rectum in biopsy and organ tissue culture
13. Flat and depressed colonic neoplasms: A prospective study of 1000 colonoscopies in the UK
14. Identification and quantification of aberrant crypt foci and microadenomas in the human colon
15. Histology of aberrant crypt foci in the human colon
16. Aberrant crypt foci of the colon as precursors of adenoma and cancer
17. Etiology of colorectal cancer with emphasis on mechanisms of action and prevention
18. Chemo- and dietary prevention of colorectal cancer
19. Incidence of colorectal cancer in proctocolitis: A retrospective study of 959 cases over 40 years
20. Incidence and familial occurrence of colorectal cancer and polyps in a Health-Care district of Northern Italy
21. Hereditary nonpolyposis colorectal cancer (Lynch syndrome)
22. Recent advances in molecular genetics of colorectal cancer
23. Molecular mechanisms underlying hereditary nonpolyposis colorectal carcinoma
24. Hereditary nonpolyposis colorectal cancer: Review of clinical, molecular genetics, and counseling aspects
25. Gardner's syndrome. Recent development in research and management
26. Upper gastrointestinal disease in patients with familial adenomatous polyposis
27. The PAC tumor suppressor protein in development and cancer
28. Phenotypic differences in familial adenomatous polyposis based on APC gene mutation status
29. Functional interaction of an axin homolog conductin, with β-catenin, APC, and GSK3β
30. The molecular basis of Turcot's syndrome
31. Polyposis: The Peutz-Jeghers syndrome
32. Multiple hamartoma syndrome (Cowden's disease)
33. Familial juvenile polyposis. Study of a kindred: Evolution of polyps and relationship to gastrointestinal carcinoma
34. Genetic linkage in Muir-Torre syndrome to the same chromosomal region as cancer family syndrome
35. Hereditary gastrointestinal polyposis syndromes
36. Surgical treatment of Cronkhite-Canada syndrome associated with protein-losing enteropathy
37. Tritiated thymidine labeling distribution as a marker for hereditary predisposition to colon cancer
38. Rectal epithelial cell proliferation in a group in young adults
39. A genetic model for colorectal tumorigenesis
40. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression
41. Characteristic chromosomal imbalances in 18 near-diploid colorectal tumors
42. Identification of colon cancer-predisposed individuals: A cytogenetic analysis
43. Advances in molecular genetics
44. The DCC protein and prognosis in colorectal cancer
45. Evaluation of the FHIT gene in colorectal cancers
46. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
47. Increased expression of cyclin D1 is an early event in multi-stage colorectal carcinogenesis
48. Smad 3 mutant mice develop metastatic colorecal cancer
49. Activating SRC mutation in a subset of advanced human colon cancers
50. Alterations of the PPP2R1B gene in human lung and colon cancer
51. A role for chromosome 1 in colorectal cancer
52. APC gene mutation is associated with a dominant-negative effect upon intestinal cell migration
53. Lessons from hereditary colorectal cancer
54. - colon carcinoma
55. Loss of β-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene
56. Kirsten ras mutations in patients with colorectal cancer: The multicenter "RASCAL" study
57. Allelic loss of chromosome 18q and prognosis in colorectal cancer
58. Expression and alternative splicing of the Deleted in Colorectal Cancer (DCC) gene in normal and malignant tissues
59. DCC: Linking tumour suppressor genes and altered cell surface interactions in cancer?
60. Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: Link between cell cycle control and malignant transformation
61. Mechanisms for the involvement of DNA methylation in colon carcinogenesis
62. Hypermethylation of multiple genes in pancreatic adenocarcinoma
63. Mutation in the TP53 gene in colorectal carcinoma detected by polymerase chain reaction
64. P53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers
65. P53 in life and death
66. The emerging p53 gene family
67. Molecular genetic tests as a guide to surgical management of familial adenomatous polyposis
68. Clinical features and genotype-phenotype correlations in 41 Italian families with adenomatosis coli
69. Alternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC
70. Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps
71. APC mutations occur early during colorectal tumorigenesis
72. Hereditary cancer, oncogenes, and antioncogenes
73. Peutz-Jeghers syndrome: 78-year follow-up of the original family
74. Increased risk of cancer in the Peutz-Jeghers syndrome
75. No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas
76. Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer
77. Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome
78. Juvenile polyposis: Intramucosal signet-cell adenocarcinoma arising in a polyp at a gastrojejunostomy site
79. Malignant potential of juvenile polyposis coli. Report of a case and review of the literature
80. Juvenile polyposis: A case with early presentation and death attributable to adenocarcinoma of the pancreas
81. PTEN germ-line mutations in juvenile polyposis coli
82. Mutations in the SMAD4/DPC4 gene in juvenile polyposis
83. Direct genetic testing for Smad4 mutations in patients at risk for juvenile polyposis
84. The Cowden syndrome: A clinical and genetic study in 21 patients
85. Cowden's disease: A possible new symptom complex with multiple system involvement
86. Hamartoneoplastic syndromes
87. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer
88. Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndrome
89. Allelic imbalance, including deletion of PTEN/NMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation
90. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
91. Germ-line msh6 mutations in colorectal cancer families
92. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
93. Colorectal cancer prevention and treatment
94. Mutation screening in the hMLH1 gene in Swedish hereditary nonpolyposis colon cancer families
95. Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 eastern United States hereditary nonpolyposis colorectal cancer pedigrees
96. Hereditary colorectal cancer in the general population: From cancer registration to molecular diagnosis
97. Monoallelic mutation analysis (MAMA) for identifying germline mutations
98. Microsatellite instability: Marker of a mutator phenotype in cancer
99. DNA mismatch repair and cancer
100. Mutator phenotype may be required for multistage carcinogenesis
101. Colorectal adenomas in surgical specimens from subjects with hereditary nonpolyposis colorectal cancer
102. Aggressive polyps in hereditary nonpolyposis colorectal cancer: Targets for screening
103. Frequency and type of colorectal tumors in asymptomatic high-risk individuals in families with hereditary nonpolyposis colorectal cancer
104. Hereditary cancer in adults
105. If aggressive surveillance in hereditary nonpolyposis colorectal cancer is now state of the art, are there any challenges left?
106. Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer
107. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
108. Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae
109. Microsatellite instability: The mutator that mutates the other mutator
110. Proapoptotic gene BAX is frequently mutated in hereditary non-polyposis colorectal cancers but not in adenomas
111. Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor
112. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability
113. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
114. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
115. Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers
116. Flow cytometry and prognostic implications in patients with solid tumors
117. Mutations of mitotic checkpoint genes in human cancers
118. A checkpoint on the road to cancer
119. Ulcerative colitis and colorectal cancer: A population-based study
120. Similarity of colorectal cancer in Crohn's disease and ulcerative colitis: Implications for carcinogenesis and prevention
121. Significance and detection of dysplasia in chronic colitis
122. Rectal cell renewal as biological marker of cancer risk in ulcerative colitis
123. The pathology and politics of dysplasia in ulcerative colitis
124. P53 and β catenin expression in chronic ulcerative colitis-associated polypois dysplasia And sporadic adenomas. An immunohistochemical study
125. Colonic epithelium is diffusely abnormal in ulcerative colitis and colorectal cancer
126. Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation
127. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis
128. Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers
129. INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis
130. Multifocal neoplasia involving the colon and appendix in ulcerative colitis: Pathological and molecular features
131. Frequency of hereditary colorectal carcinoma
132. Family studies in cancer of the colon and rectum
133. A genetic study of carcinoma of the large bowel
134. Familial aggregation of tumors in the three-year experience of a population-based colorectal cancer registry
135. Familial colorectal cancer in Ashkenazi due to a hypermutable tract in APC
136. The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer
137. The I1307K polymorphism of the APC gene in colorectal cancer
138. Excess risk of colon cancer associated with a polymorphism of the APC gene?
139. Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer
140. Molecular analysis of the BRCA1 and BRCA2 genes in 32 breast and/or ovarian cancer Spanish families
141. Adenomas of large bowel